Aspartic peptidase of Phialophora verrucosa as target of HIV peptidase inhibitors: blockage of its enzymatic activity and interference with fungal growth and macrophage interaction

Autor: Marcela Q. Granato, Ingrid S. Sousa, Thabatta L. S. A. Rosa, Diego S. Gonçalves, Sergio H. Seabra, Daniela S. Alviano, Maria C. V. Pessolani, André L. S. Santos, Lucimar F. Kneipp

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 629-638 (2020)

Phialophora verrucosa causes several fungal human diseases, mainly chromoblastomycosis, which is extremely difficult to treat. Several studies have shown that human immunodeficiency virus peptidase inhibitors (HIV-PIs) are attractive candidates for a

Externí odkaz: https://doaj.org/article/ca99bc82f961427392eed43e75575058

Aspartic peptidase of Phialophora verrucosa as target of HIV peptidase inhibitors: blockage of its enzymatic activity and interference with fungal growth and macrophage interaction

Autor: Maria Cristina Vidal Pessolani, Daniela S. Alviano, Ingrid S. Sousa, Diego de Souza Gonçalves, Thabatta L. S. A. Rosa, Sergio Henrique Seabra, Marcela Q. Granato, Lucimar F. Kneipp, André L.S. Santos

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 629-638 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry

Phialophora verrucosa causes several fungal human diseases, mainly chromoblastomycosis, which is extremely difficult to treat. Several studies have shown that human immunodeficiency virus peptidase inhibitors (HIV-PIs) are attractive candidates for a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e85d0455b4795fd43f70016eaea092
https://doi.org/10.1080/14756366.2020.1724994

Aspartic Peptidases of Human Pathogenic Trypanosomatids: Perspectives and Trends for Chemotherapy

Autor: M. Catanho, Marta H. Branquinha, A. L. S. Santos, Claudia M. d’Avila-Levy, Lívia O. Santos, Cátia Lacerda Sodré, A. S. Garcia-Gomes

Publikováno v: Current Medicinal Chemistry

Aspartic peptidases are proteolytic enzymes present in many organisms like vertebrates, plants, fungi, protozoa and in some retroviruses such as human immunodeficiency virus (HIV). These enzymes are involved in important metabolic processes in microo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d43d3c54ac9ee8aff3b89bed041b54
https://doi.org/10.2174/0929867311320250007

Nelfinavir is effective in inhibiting the multiplication and aspartic peptidase activity of Leishmania species, including strains obtained from HIV-positive patients

Autor: Claudia M. d’Avila-Levy, Lívia O. Santos, André L.S. Santos, Marta H. Branquinha, Conceição M. Pedroso e Silva, Bianca da Silva Vitório

Publikováno v: Journal of Antimicrobial Chemotherapy

Objectives: There is a general lack of effective and non-toxic chemotherapeutic agents for leishmaniasis and there is as yet no study about the effect of HIV peptidase inhibitors (HIV PIs) on Leishmania/HIV-coinfected patients. In the present work, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1f2a9631731a68cc9361eba420038b
https://doi.org/10.1093/jac/dks410

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