Zobrazeno 1 - 10
of 835
pro vyhledávání: '"HIV latency"'
Autor:
Erick De La Torre Tarazona, Caroline Passaes, Santiago Moreno, Asier Sáez-Cirión, José Alcamí
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Maraviroc (MVC) is an antiretroviral drug capable of binding to CCR5 receptors and block HIV entry into target cells. Moreover, MVC can activate NF-kB pathway and induce viral transcription in HIV-infected cells, being proposed as a latency
Externí odkaz:
https://doaj.org/article/0e11a0a1d69042ada533cb96292a1509
Autor:
Lin Yin, Qimin Wang, Siyuan Liu, Jun Chen, Yujiao Zhang, Lingqing Lu, Hongzhou Lu, Zhigang Song, Lijun Zhang
Publikováno v:
Proteome Science, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Patients with immunodeficiency virus-1 (HIV-1) infection are challenging to be cured completely due to the existence of HIV-1 latency reservoirs. However, the knowledge of the mechanisms and biomarkers associated with HIV-1 latenc
Externí odkaz:
https://doaj.org/article/15515838c157462bb832e1566f69b67e
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/bbeaed822c0245668c5f90e4c9026d32
Autor:
Richard Oriko Owor, Carol Kawuma, Gauden Nantale, Kenedy Kiyimba, Samuel Baker Obakiro, Simple Ouma, Jalia Lulenzi, Yahaya Gavamukulya, Mercy Chebijira, Tonny Wotoyitide Lukwago, Moses Egor, Peter Musagala, Moses Andima, Dan Kibuule, Paul Waako, Joseph Hokello
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e31908- (2024)
Currently, highly active antiretroviral therapy is unable to cure HIV/AIDS because of HIV latency. This study aimed at documenting medicinal plants used in the management of HIV/AIDS in Eastern Uganda so as to identify phytochemicals with HIV latency
Externí odkaz:
https://doaj.org/article/f25224ebf7cb4be88da581415771c346
Autor:
Ujjwal Rathore, Paige Haas, Vigneshwari Easwar Kumar, Joseph Hiatt, Kelsey M. Haas, Mehdi Bouhaddou, Danielle L. Swaney, Erica Stevenson, Lorena Zuliani-Alvarez, Michael J. McGregor, Autumn Turner-Groth, Charles Ochieng' Olwal, Yaw Bediako, Hannes Braberg, Margaret Soucheray, Melanie Ott, Manon Eckhardt, Judd F. Hultquist, Alexander Marson, Robyn M. Kaake, Nevan J. Krogan
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTDuring HIV infection of CD4+ T cells, ubiquitin pathways are essential to viral replication and host innate immune response; however, the role of specific E3 ubiquitin ligases is not well understood. Proteomics analyses identified 116 single-
Externí odkaz:
https://doaj.org/article/a68bf9f80cd74600b676bdd895184026
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101203- (2024)
Despite the success of combination antiretroviral therapy (cART) in HIV treatment, a cure for HIV remains elusive. Scientists postulate that HIV latent reservoirs may be a vital target in curative strategies. Vorinostat is a latency-reversing agent t
Externí odkaz:
https://doaj.org/article/c2b0f8b04f0245dd9cdae0cadd28431e
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT A complete cure against human immunodeficiency virus (HIV) infection remains out of reach, as the virus persists in stable cell reservoirs that are resistant to antiretroviral therapy. The key to eliminating these reservoirs lies in decipher
Externí odkaz:
https://doaj.org/article/c8a493bdd08544c19819ea53a23496d8
Publikováno v:
Pathogens and Immunity, Vol 8, Iss 1 (2023)
The inaugural FASEB HIV Reservoirs and Immune Control Conference brought researchers together from across the globe to discuss reservoir dynamics in clinical cohorts. It extended over 4 days in the seaside town of Malahide, Ireland. The scientific se
Externí odkaz:
https://doaj.org/article/d0eb302487b14973a85a09382e436e05
Autor:
Xinlian Zhang, Andrew A. Qazi, Savitha Deshmukh, Roni Lobato Ventura, Amey Mukim, Nadejda Beliakova-Bethell
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
BackgroundThe latent HIV reservoir represents the major barrier to a cure. One curative strategy is targeting diseased cells for elimination based on biomarkers that uniquely define these cells. Single-cell RNA sequencing (scRNA-seq) has enabled the
Externí odkaz:
https://doaj.org/article/6887df33b48e4257a9d99a5e4913cc10
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The immune system of people living with HIV (PLWH) is persistently exposed to antigens leading to systemic inflammation despite combination antiretroviral treatment (cART). This inflammatory milieu promotes T-cell activation and exhaustion. Furthermo
Externí odkaz:
https://doaj.org/article/a7b307119186420eac3802d288dc0ce9