Signal peptide exchange alters HIV-1 envelope antigenicity and immunogenicity.

Autor: Upadhyay C; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Rao P; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Behzadi MA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Feyznezhad R; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Lambert GS; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Kumar R; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Kumar M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Yang W; Department of Pathology, Johns Hopkins University, Baltimore, MD, United States., Jiang X; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, United States., Luo CC; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, United States., Nadas A; Department of Environment Medicine, New York University Grossman School of Medicine, New York, NY, United States., Arthos J; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States., Kong XP; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, United States., Zhang H; Department of Pathology, Johns Hopkins University, Baltimore, MD, United States., Hioe CE; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Research Service, James J. Peters VA Medical Center, Bronx, NY, United States., Duty JA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Sep 24; Vol. 15, pp. 1476924. Date of Electronic Publication: 2024 Sep 24 (Print Publication: 2024).

Investigating the Effect of GLU283 Protonation State on the Conformational Heterogeneity of CCR5 by Molecular Dynamics Simulations.

Autor: Dogan B; Department of Biochemistry, School of Medicine, Bahcesehir University, Istanbul 34353, Türkiye.; Deparment of Chemistry, Istanbul Technical University, Maslak, Istanbul 34469, Türkiye., Durdağı S; Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahcesehir University, Istanbul 34353, Türkiye.; Molecular Therapy Lab, Department of Pharmaceutical Chemistry, School of Pharmacy, Bahcesehir University, Istanbul 34353, Türkiye.; Lab for Innovative Drugs (Lab4IND), Computational Drug Design Center (HITMER), Bahçeşehir University, Istanbul 34353, Türkiye.

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2024 Nov 11; Vol. 64 (21), pp. 8283-8298. Date of Electronic Publication: 2024 Oct 22.

HIV1 gp120 activates microglia via TLR2-nf-κb signaling to up-regulate inflammatory cytokine expression and induce neuropathic pain.

Autor: Sun Y; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, China., Zhang C; Department of Biological Sciences, University of Denver (currently at Entos Pharmaceuticals), Denver, CO 80210, USA., Lei T; Department of Orthopedic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China., Lin F; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, China., Huang J; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, China., Hu Y; The First Affiliated Hospital,College of Medicine,Zhejiang University, Hangzhou, 310003, China., Wang D; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, China., Zhang W; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, China. Electronic address: wenpingzhang@zstu.edu.cn.

Publikováno v: Neuropharmacology [Neuropharmacology] 2024 Dec 01; Vol. 260, pp. 110136. Date of Electronic Publication: 2024 Aug 30.

Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation.

Autor: Zhang P; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: zhangp@ihm.ac.cn., Gorman J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA., Tsybovsky Y; Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Lu M; Department of Cellular and Molecular Biology, School of Medicine, University of Texas at Tyler Health Science Center, Tyler, TX 75708, USA., Liu Q; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; School of Life Science and Technology, Southeast University, Nanjing 210096, China., Gopan V; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Singh M; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Lin Y; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Miao H; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Seo Y; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Kwon A; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Olia AS; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Chuang GY; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Geng H; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Lai YT; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Zhou T; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Mascola JR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; ModeX Therapeutics, 20 Riverside Road, Weston, MA 02493, USA., Mothes W; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Lusso P; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: plusso@niaid.nih.gov.

Publikováno v: Cell reports [Cell Rep] 2024 Aug 27; Vol. 43 (8), pp. 114518. Date of Electronic Publication: 2024 Jul 18.

HIV and influenza fusion peptide interactions with (dis)ordered lipid bilayers: Understanding mechanisms and implications for antimicrobial and antiviral approaches.

Autor: Miłogrodzka I; Department of Chemical and Biological Engineering, Monash University, Clayton, Victoria, Australia; Australian Synchrotron, Clayton, Victoria, Australia., Le Brun AP; Australian Centre for Neutron Scattering, Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW, Australia., Banaszak Holl MM; Department of Chemical and Biological Engineering, Monash University, Clayton, Victoria, Australia; Department of Mechanical and Materials Engineering, University of Alabama at Birmingham, Birmingham, AL, USA; Division of Pulmonology, Allergy, and Critical Care Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., van 't Hag L; Department of Chemical and Biological Engineering, Monash University, Clayton, Victoria, Australia. Electronic address: Leonie.VantHag@monash.edu.

Publikováno v: Journal of colloid and interface science [J Colloid Interface Sci] 2024 Sep 15; Vol. 670, pp. 563-575. Date of Electronic Publication: 2024 May 11.