Zobrazeno 1 - 10
of 948
pro vyhledávání: '"HIV Reservoir"'
Publikováno v:
Retrovirology, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Background The rapid establishment and persistence of latent HIV-1 reservoirs is one of the main obstacles towards an HIV cure. While antiretroviral therapy supresses viral replication, it does not eradicate the latent reservoir of HIV-1-inf
Externí odkaz:
https://doaj.org/article/22febeae15034ac2b34bf68302e29be4
Autor:
Trevor Khaba, Andrea Olga Papadopoulos, Thandeka Nkosi, Sifundo Nxele, Thandekile Ngubane, Ismail Jajbhay, Johan Pansegrouw, Zaza M. Ndhlovu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionStudying diseased human tissues offers better insights into the intricate interactions between pathogens and the human host. In conditions such as HIV and cancers, where diseases primarily manifest in tissues, peripheral blood studies are
Externí odkaz:
https://doaj.org/article/01aa2430acaa406abdf464ada98acc7e
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/bbeaed822c0245668c5f90e4c9026d32
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e30394- (2024)
Introduction: CoronaVac, an inactivated vaccine developed by Sinovac Life Sciences, has been widely used for protection against Coronavirus Disease 2019 (COVID-19). This study investigates its effect on the HIV reservoir and T cell repertoires in peo
Externí odkaz:
https://doaj.org/article/16a57f9bbab1464ab9f5044f2096b9dd
Autor:
Camille Vellas, Manon Nayrac, Nived Collercandy, Mary Requena, Nicolas Jeanne, Justine Latour, Chloé Dimeglio, Michelle Cazabat, Karl Barange, Laurent Alric, Nicolas Carrere, Guillaume Martin-Blondel, Jacques Izopet, Pierre Delobel
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104954- (2024)
Summary: Background: The persistence of intact replication-competent HIV-1 proviruses is responsible for the virological rebound off treatment. The gut could be a major reservoir of HIV-1 due to the high number of infected target cells. Methods: We c
Externí odkaz:
https://doaj.org/article/f079adb1e98542558615c5681012ed94
Publikováno v:
Pathogens and Immunity, Vol 8, Iss 2 (2024)
Background: The primary hurdle to curing HIV is due to the establishment of a reservoir early in infection. In an effort to find new treatment strategies, we and others have focused on understanding the selection pressures exerted on the reservoir by
Externí odkaz:
https://doaj.org/article/1daacb0028114ff39505fc2386e9139f
Autor:
Natalie N. Kinloch, Aniqa Shahid, Winnie Dong, Don Kirkby, Bradley R. Jones, Charlotte J. Beelen, Daniel MacMillan, Guinevere Q. Lee, Talia M. Mota, Hanwei Sudderuddin, Evan Barad, Marianne Harris, Chanson J. Brumme, R. Brad Jones, Mark A. Brockman, Jeffrey B. Joy, Zabrina L. Brumme
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTIn order to cure human immunodeficiency virus (HIV), we need to better understand the within-host evolutionary origins of the small reservoir of genome-intact proviruses that persist within infected cells during antiretroviral therapy (ART).
Externí odkaz:
https://doaj.org/article/1447a0402b68443b8658e7d4faad4893
Autor:
Xiaoyan Guo, Zerui Wang, Mengmeng Qu, Yuntian Guo, Minrui Yu, Weiguo Hong, Chao Zhang, Xing Fan, Jinwen Song, Ruonan Xu, Jiyuan Zhang, Huihuang Huang, Enqiang Linghu, Fu-Sheng Wang, Lijun Sun, Yan-Mei Jiao
Publikováno v:
mSystems, Vol 8, Iss 5 (2023)
ABSTRACT Although gut microbiota alteration and related blood microbe profiles in human immunodeficiency virus (HIV)-infected individuals are associated with the disease progression, how abnormal blood microbe profiles influence the inflammation and
Externí odkaz:
https://doaj.org/article/bb84bb07d7b341fba14a7a95a9b45bdd
Autor:
María A. Navarrete-Muñoz, Ricardo Ramos, África Holguín, Alfonso Cabello, Miguel Górgolas, José M. Benito, Norma Rallón
Publikováno v:
Virulence, Vol 13, Iss 1, Pp 1713-1719 (2022)
Accumulation of mutations in epitopes of cytolytic-T-lymphocytes immune response (CTL) in HIV-reservoir seems to be one of the reasons for shock-and-kill strategy failure. Ten non-controller patients on successful cART (TX) and seven elite controller
Externí odkaz:
https://doaj.org/article/cee6cd801afd42a686523d950160d55b
Autor:
Ryan Yucha, Morgan L. Litchford, Carolyn S. Fish, Zak A. Yaffe, Barbra A. Richardson, Elizabeth Maleche-Obimbo, Grace John-Stewart, Dalton Wamalwa, Julie Overbaugh, Dara A. Lehman
Publikováno v:
Viruses, Vol 15, Iss 10, p 2055 (2023)
A cure for HIV-1 (HIV) remains unrealized due to a reservoir of latently infected cells that persist during antiretroviral therapy (ART), with reservoir size associated with adverse health outcomes and inversely with time to viral rebound upon ART ce
Externí odkaz:
https://doaj.org/article/489be20d5acf463b8b1b2623ebeb1721