Zobrazeno 1 - 10
of 557
pro vyhledávání: '"HIV‐1 latency"'
Autor:
Uri Mbonye, Jonathan Karn
Publikováno v:
Retrovirology, Vol 21, Iss 1, Pp 1-38 (2024)
Abstract Transcriptionally latent forms of replication-competent proviruses, present primarily in a small subset of memory CD4+ T cells, pose the primary barrier to a cure for HIV-1 infection because they are the source of the viral rebound that almo
Externí odkaz:
https://doaj.org/article/3c9ce5bf7fe1422dba88460a2ea6d394
Autor:
Minh Ha Ngo, Joshua Pankrac, Ryan C. Y. Ho, Emmanuel Ndashimye, Rahul Pawa, Renata Ceccacci, Tsigereda Biru, Abayomi S. Olabode, Katja Klein, Yue Li, Colin Kovacs, Robert Assad, Jeffrey M. Jacobson, David H. Canaday, Stephen Tomusange, Samiri Jamiru, Aggrey Anok, Taddeo Kityamuweesi, Paul Buule, Ronald M. Galiwango, Steven J. Reynolds, Thomas C. Quinn, Andrew D. Redd, Jessica L. Prodger, Jamie F. S. Mann, Eric J. Arts
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTTo date, an affordable, effective treatment for an HIV-1 cure remains only a concept with most “latency reversal” agents (LRAs) lacking specificity for the latent HIV-1 reservoir and failing in early clinical trials. We assessed HIV-1 lat
Externí odkaz:
https://doaj.org/article/c4e48e2d64a24cd4aecbe0e0f13130b6
Autor:
Xiaoli Tang, Huafei Lu, Patrick M. Tarwater, David L. Silverberg, Christoph Schorl, Bharat Ramratnam
Publikováno v:
Microorganisms, Vol 12, Iss 8, p 1707 (2024)
Combinatorial antiretroviral therapy (cART) has transformed HIV infection from a death sentence to a controllable chronic disease, but cannot eliminate the virus. Latent HIV-1 reservoirs are the major obstacles to cure HIV-1 infection. Previously, we
Externí odkaz:
https://doaj.org/article/c85b77e66373454c865c151666cc6130
Autor:
María José Lista, Anne-Caroline Jousset, Mingpan Cheng, Violaine Saint-André, Elouan Perrot, Melissa Rodrigues, Carmelo Di Primo, Danielle Gadelle, Elenia Toccafondi, Emmanuel Segeral, Clarisse Berlioz-Torrent, Stéphane Emiliani, Jean-Louis Mergny, Marc Lavigne
Publikováno v:
Retrovirology, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Background Once integrated in the genome of infected cells, HIV-1 provirus is transcribed by the cellular transcription machinery. This process is regulated by both viral and cellular factors, which are necessary for an efficient viral repli
Externí odkaz:
https://doaj.org/article/65621dcf79434469bcd31a159108beb5
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/f2a4ed06a56d45e1a098877c3744d54d
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/d69cf669970e4fc08ade52c715fb12df
Publikováno v:
Viruses, Vol 15, Iss 9, p 1969 (2023)
This review summarizes current advances in the role of transcriptional stochasticity in HIV-1 latency, which were possible in a large part due to the development of single-cell approaches. HIV-1 transcription proceeds in bursts of RNA production, whi
Externí odkaz:
https://doaj.org/article/9505ab18bace4596861c52e4972fd576
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The main obstacle to cure HIV-1 is the latent reservoir. Antiretroviral therapy effectively controls viral replication, however, it does not eradicate the latent reservoir. Latent CD4+ T cells are extremely rare in HIV-1 infected patients, making pri
Externí odkaz:
https://doaj.org/article/aff97d86d87a4ae484b3cf27ee546180
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