Zobrazeno 1 - 10
of 739
pro vyhledávání: '"HITOSHI ENDOU"'
Autor:
Zitong Shi, Kazuko Kaneda-Nakashima, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Shushi Nagamori, Yoshikatsu Kanai
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Metastasis is the leading cause of mortality in cancer patients. L-type amino acid transporter 1 (LAT1, SLC7A5) is a Na+-independent neutral amino acid transporter highly expressed in various cancers to support their growth. Although high LA
Externí odkaz:
https://doaj.org/article/62d8a5ee21434925ba4bb14b499994a8
Autor:
Kou Nishikubo, Ryuichi Ohgaki, Xingming Liu, Hiroki Okanishi, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background Cytotoxic anticancer drugs widely used in cancer chemotherapy have some limitations, such as the development of side effects and drug resistance. Furthermore, monotherapy is often less effective against heterogeneous cancer tissue
Externí odkaz:
https://doaj.org/article/e7e3be8231c3463188c9c0702abadfcd
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract Background Cancer-upregulated l-type amino acid transporter 1 (LAT1; SLC7A5) supplies essential amino acids to cancer cells. LAT1 substrates are not only needed for cancer rapid growth, but involved in cellular signaling. LAT1 has been propo
Externí odkaz:
https://doaj.org/article/1d18ba2038834ce497e31abb1bbd3315
Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma
Autor:
Narangerel Jigjidkhorloo, Kohsuke Kanekura, Jun Matsubayashi, Daigo Akahane, Koji Fujita, Keiki Oikawa, Atsushi Kurata, Masakatsu Takanashi, Hitoshi Endou, Toshitaka Nagao, Akihiko Gotoh, Oyundelger Norov, Masahiko Kuroda
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract L-type neutral amino acid transporter 1 (LAT1) is a heterodimeric membrane transport protein involved in neutral amino acid transport. LAT1 is highly expressed in various malignant solid tumors and plays an essential role in cell proliferati
Externí odkaz:
https://doaj.org/article/254f7aaec22f4688a7954b03fd1e965b
Autor:
Lili Quan, Ryuichi Ohgaki, Saori Hara, Suguru Okuda, Ling Wei, Hiroki Okanishi, Shushi Nagamori, Hitoshi Endou, Yoshikatsu Kanai
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-17 (2020)
Abstract Background Tumor angiogenesis is regarded as a rational anti-cancer target. The efficacy and indications of anti-angiogenic therapies in clinical practice, however, are relatively limited. Therefore, there still exists a demand for revealing
Externí odkaz:
https://doaj.org/article/9d23bfa9474346bb8ea9a8e59577d0dc
Autor:
Osamu Kaminuma, Tomoe Nishimura, Mayumi Saeki, Norimasa Yamasaki, Sawako Ogata, Tomoe Fujita, Hitoshi Endou, Keitaro Hayashi
Publikováno v:
Allergology International, Vol 69, Iss 3, Pp 455-458 (2020)
Externí odkaz:
https://doaj.org/article/195db56ca2eb45e98ae53872920009fa
Publikováno v:
Kidney & Blood Pressure Research, Pp 1-12 (2020)
Introduction: The kidneys play a central role in eliminating metabolic waste products and drugs through transporter-mediated excretion along the proximal tubule. This task is mostly achieved through a variety of transporters from the solute carrier f
Externí odkaz:
https://doaj.org/article/37311929f14b40d7a3f002ec03f05849
Autor:
Silvia Panetti, Nicola McJannett, Livingstone Fultang, Sarah Booth, Luciana Gneo, Ugo Scarpa, Charles Smith, Ashley Vardon, Lisa Vettore, Celina Whalley, Yi Pan, Csilla Várnai, Hitoshi Endou, Jonathan Barlow, Daniel Tennant, Andrew Beggs, Francis Mussai, Carmela De Santo
Publikováno v:
Blood Advances. 7:1754-1761
Cancer cells take up amino acids from the extracellular space to drive cell proliferation and viability. Similar mechanisms are applied by immune cells, resulting in the competition between conventional T cells, or indeed chimeric antigen receptor (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8489c37ab725f064e6a73f4a32e70bc8
https://doi.org/10.1182/bloodadvances.2022008272
https://doi.org/10.1182/bloodadvances.2022008272
Autor:
Keitaro Hayashi, Promsuk Jutabha, Sumiko Maeda, Yothaisong Supak, Motoshi Ouchi, Hitoshi Endou, Tomoe Fujita, Masayuki Chida, Naohiko Anzai
Publikováno v:
Journal of Pharmacological Sciences, Vol 132, Iss 3, Pp 201-204 (2016)
L-type amino acid transporter 1 (LAT1, SLC7A5) incorporates essential amino acids into cells. Recent studies have shown that LAT1 is a predominant transporter in various human cancers. However, the function of LAT1 in thymic carcinoma remains unknown
Externí odkaz:
https://doaj.org/article/6058706be7b249baabd7f8730bb9aec4
Autor:
Seiji Ueno, Toru Kimura, Takashi Yamaga, Akihiko Kawada, Toshiaki Ochiai, Hitoshi Endou, Hiroyuki Sakurai
Publikováno v:
Journal of Pharmacological Sciences, Vol 131, Iss 2, Pp 110-117 (2016)
Background: In many cancer cells, L-type amino acid transporter 1 (LAT1) transports neutral amino acids with bulky side chain, which activate mammalian target of rapamycin (mTOR) to cause cell proliferation. An anti-diabetic drug, metformin, has been
Externí odkaz:
https://doaj.org/article/b9fa6b447d814cee9c10f9e7bced68ed