Výsledky vyhledávání - "HISASHI MIHARA"

Akademický článek

Exogenous Ceramide Serves as a Precursor to Endogenous Ceramide Synthesis and as a Modulator of Keratinocyte Differentiation

Autor: Kyong-Oh Shin, Hisashi Mihara, Kenya Ishida, Yoshikazu Uchida, Kyungho Park

Publikováno v: Cells, Vol 11, Iss 11, p 1742 (2022)

Since ceramide is a key epidermal barrier constituent and its deficiency causes barrier-compromised skin, several molecular types of ceramides are formulated in commercial topical agents to improve barrier function. Topical ceramide localizes on the

Externí odkaz: https://doaj.org/article/65696ea46324476ca5c0518339bf218a

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Design, Synthesis, and Structure–Activity Relationships Study of N-Pyrimidyl/Pyridyl-2-thiazolamine Analogues as Novel Positive Allosteric Modulators of M3 Muscarinic Acetylcholine Receptor

Autor: Hideyoshi Fuji, Eiji Kawaminami, Katsutoshi Ino, Taisuke Takahashi, Kenichiro Ishizu, Michinori Akaiwa, Hisashi Mihara, Risa Okimoto, Kenji Negoro, Hiroaki Tanaka

Publikováno v: Chemical and Pharmaceutical Bulletin. 69:360-373

The M3 muscarinic acetylcholine receptor (mAChR) plays an essential pharmacological role in mediating a broad range of actions of acetylcholine (ACh) released throughout the periphery and central nerve system (CNS). Nevertheless, its agonistic functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28c0b3aab3d69e27ded3b916ab532e73
https://doi.org/10.1248/cpb.c20-00877

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Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis

Autor: Shunsuke Takasuga, Hiroshi Hasegawa, Hideo Fukuhara, Motomu Kanai, Michael A. Frohman, Akihiko Nishikimi, Hisashi Mihara, Takehiko Sasaki, Yasunori Kanaho, Yoshihiko Tanaka, Qinhong Cao, Tsunaki Hongu, Wenjuan Su, Masakatsu Shibasaki, Yoshinori Fukui, Fumiyuki Sanematsu

Publikováno v: Science. 324:384-387

During chemotaxis, activation of the small guanosine triphosphatase Rac is spatially regulated to organize the extension of membrane protrusions in the direction of migration. In neutrophils, Rac activation is primarily mediated by DOCK2, an atypical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780fe35dd860bff38554b849ad059427
https://doi.org/10.1126/science.1170179

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Preparation and Formation Mechanism of Mesoporous Titania Particles Having Crystalline Wall

Autor: Taku Ogura, Hideki Sakai, Hirobumi Shibata, Takahiro Ohkubo, Hisashi Mihara, Tatsuya Mukai, Masahiko Abe, Hiroki Kohno

Publikováno v: Chemistry of Materials. 18:2256-2260

Mesoporous titania particles having anatase-type crystalline wall were prepared using a low-temperature crystallization technique. Crystalline mesoporous titania was obtained through the sol−gel process of titanium oxysulfate sulfuric acid hydrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::580b98b0516583cde7793d4ad76efce5
https://doi.org/10.1021/cm0524042

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Concise total synthesis of flavone C-glycoside having potent anti-inflammatory activity

Autor: Toshiyuki Wakimoto, Haruo Nukaya, Sachiko Kondo, Kiyoshi Tanaka, Tomoyuki Kimura, Hisashi Mihara, Kuniro Tsuji, Takumi Furuta

Publikováno v: Tetrahedron. 60:9375-9379

The total synthesis of anti-inflammatory active flavone C-glycoside isolated from oolong tea extract is achieved. Introducing a C-glucosyl moiety to an aryl system and constructing a fused tetracyclic ring characteristic to this natural product were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e5c377cabba10fef3a1f13c4d545bc2
https://doi.org/10.1016/j.tet.2004.08.015

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