Výsledky vyhledávání - "HIROTSUGU SUGIHARA"

Epstein–Barr Virus Lytic Reactivation Induces IgG4 Production by Host B Lymphocytes in Graves' Disease Patients and Controls: A Subset of Graves' Disease Is an IgG4-Related Disease-Like Condition

Autor: Hirotsugu Sugihara, Shunsuke Tanio, Kazuhiko Hayashi, Yuji Nakayama, Sayuri Hara, Masako Kato, Katsumi Higaki, Kiyosuke Ishiguro, Keiko Nagata, Michiko Matsushita, Satoshi Kuwamoto

Publikováno v: Viral Immunology

Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a newly recognized systemic fibroinflammatory disease with characteristic histological findings and high serum IgG4 levels. Epstein–Barr virus (EBV) is a persistent herpesvirus in B lymphocytes, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d5811547ce542cc8dfa5527dcb4148
https://doi.org/10.1089/vim.2018.0042

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Aberrant expression of AID and AID activators of NF-κB and PAX5 is irrelevant to EBV-associated gastric cancers, but is associated with carcinogenesis in certain EBV-non-associated gastric cancers

Autor: Takashi Mohri, Michiko Matsushita, Yasushi Horie, Masako Kato, Kazuhiko Hayashi, Keiko Nagata, Satoshi Kuwamoto, Ichiro Murakami, Hirotsugu Sugihara

Publikováno v: Oncology Letters

Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is a distinct subtype of gastric cancer characterized by clinicopathological features including lymphoepithelioma-like histology. Aberrant expression of activation-induced cytidine deaminase (A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98cfa7a2aa460d2c4a14b2a4964afe0
https://doi.org/10.3892/ol.2017.5978

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Epstein–Barr Virus Lytic Reactivation Activates B Cells Polyclonally and Induces Activation-Induced Cytidine Deaminase Expression: A Mechanism Underlying Autoimmunity and Its Contribution to Graves' Disease

Autor: Masako Kato, Michiko Matsushita, Satoshi Kuwamoto, Hirotsugu Sugihara, Kazuhiko Hayashi, Yuji Nakayama, Keisuke Kumata, Sayuri Hara, Keiko Nagata, Yukio Satoh, Ichiro Murakami

Publikováno v: Viral Immunology

Graves' disease is an autoimmune disease that results in and is the most common cause of hyperthyroidism, and the reactivation of persisting Epstein–Barr virus (EBV) in B lymphocytes induces the differentiation of host B cells into plasma cells. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c254419b6d229fe091f25962419e21a1
https://doi.org/10.1089/vim.2016.0179

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A new animal model for primary and persistent Epstein–Barr virus infection: Human EBV-infected rabbit characteristics determined using sequential imaging and pathological analysis

Autor: Kensuke Ando, Kazuaki Takashima, Hirotsugu Sugihara, Kazuhiko Hayashi, Takeshi Sairenji, Makoto Ohashi, Keisuke Okuno, Yukisato Kitamura, Kensuke Nagashima

Publikováno v: Journal of Medical Virology. 80:455-466

Most adults have persistent Epstein-Barr virus (EBV)-infection. Adolescents and young adults with primary EBV-infection frequently develop infectious mononucleosis. Latent EBV-infection is associated with various diseases, neoplasms, and hematologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194eee6a7fb7e508415cf10c642ec53b
https://doi.org/10.1002/jmv.21102

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EBNA-2 -deleted Epstein-Barr virus from P3HR-1 can infect rabbits with lower efficiency than prototype Epstein-Barr virus from B95-8

Autor: Kaoru Kato, Hitoshi Sano, Kiyoshige Yamamoto, Kazuhiko Hayashi, Masako Kato, Keisuke Okuno, Susumu Kanzaki, Hirotsugu Sugihara, Keiko Nagata, Hiromi Higaki-Mori, Satoshi Kuwamoto, Kyousuke Kanai, Ichiro Murakami

Publikováno v: Intervirology. 56(2)

Objectives: To clarify characteristics on rabbit in vivo infection with type 2 EBV nuclear antigen (EBNA-2)-deleted Epstein-Barr virus (P3HR-1-EBV) and compare infectious efficacy of P3HR-1-EBV with previously reported prototype type 1 EBV from B95-8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ced17231f1443672c7fa6a7fb927e92
https://pubmed.ncbi.nlm.nih.gov/23295915

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Synthetic Peptides of Epstein–Barr Virus-major Envelope Glycoprotein-350/220 do not Prevent Infection in a Rabbit Epstein–Barr Virus Infection Model

Autor: Kaoru Kato, Hirotsugu Sugihara, Ichiro Murakami, Satoshi Kuwamoto, Hitoshi Sano, Kyosuke Kanai, Masako Kato, Kazuhiko Hayashi, Keiko Nagata

Publikováno v: Journal of Vaccines & Vaccination.

Epstein–Barr virus (EBV) is a ubiquitous herpes virus that usually infects humans asymptomatically, occasionally inducing various EBV-associated diseases, including infectious mononucleosis (IM), chronic active EBV infection, and different types of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87af7c64664acc0c844e070eb67673d9
https://doi.org/10.4172/2157-7560.1000150

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The influence of Epstein-Barr virus reactivation in patients with Graves' disease

Autor: Keiko Nagata, Ichiro Murakami, Kazuhiko Hayashi, Satoshi Kuwamoto, Shuji Fukata, Kyosuke Kanai, Yukio Satoh, Takeshi Sairenji, Hirotsugu Sugihara, Masako Kato, Takaya Segawa

Publikováno v: Viral immunology. 24(2)

In Graves' disease, the IgG class autoantibody against thyrotropin receptor (TRAb) is produced excessively and induces hyperthyroidism. Epstein-Barr virus (EBV) is one of the human herpesviruses that persists for life, mainly in B lymphocytes, and is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a1479ae8c7c2a0af67a5838d270b21
https://pubmed.ncbi.nlm.nih.gov/21449724

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Epstein-Barr virus can infect rabbits by the intranasal or peroral route: an animal model for natural primary EBV infection in humans

Autor: Makoto Ohashi, Kazuaki Takashima, Hirotsugu Sugihara, Kazuhiko Hayashi, Masako Kato, Keisuke Okuno, Takeshi Sairenji, Susumu Kanzaki, Ryosuke Hyuga, Satoshi Kuwamoto, Hitoshi Sano, Kyosuke Kanai

Publikováno v: Journal of medical virology. 82(6)

Epstein–Barr virus (EBV) is spread universally in humans, and it causes infectious mononucleosis and sometimes induces serious EBV-associated disease. The detailed mechanism of primary infection in humans has remained unclear, because it is difficu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3819a1f24d59856a9aacd5f1e23592e6
https://pubmed.ncbi.nlm.nih.gov/20419811

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Lifelong persistent EBV infection of rabbits with EBER1-positive lymphocyte infiltration and mild sublethal hemophagocytosis

Autor: Masako Kato, Hiromi Higaki, Hirotsugu Sugihara, Kazuhiko Hayashi, Satoshi Kuwamoto, Kaoru Kato, Keisuke Okuno, Kyosuke Kanai, Ichiro Murakami, Keiko Nagata, Hitoshi Sano, Kazuaki Takashima

Publikováno v: Virus research. 153(1)

Most humans become lifelong carriers of Epstein–Barr virus (EBV) by adulthood. Primary EBV infection in adolescents causes in one to two-third of cases infectious mononucleosis. EBV infection is associated with various diseases, neoplasms and hemat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281370212c27b7f814bb1205b5117acf
https://pubmed.ncbi.nlm.nih.gov/20691737

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