Zobrazeno 1 - 10
of 111
pro vyhledávání: '"HIROTADA FUJII"'
Publikováno v:
Free Radical Research. 55:950-957
Nitroxide compounds have been used as redox-sensitive imaging probes by electron paramagnetic resonance (EPR) for assessing oxidative stress in vivo. Fast redox reactions of nitroxide radicals are favorable for assessment of higher redox sensitivity;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c69fb19f8a7489b296fa251c0b8ee9a
https://doi.org/10.1080/10715762.2021.1991918
https://doi.org/10.1080/10715762.2021.1991918
Autor:
Miho C. Emoto, Hirotada Fujii, Shun Shimohama, Hideo Sato-Akaba, Katsuya Kawanishi, Naoya Hamaue, Hisashi Koshino
Publikováno v:
Free Radical Biology and Medicine. 172:9-18
Alzheimer's disease (AD) is a common neurodegenerative disease that causes progressive cognitive decline. Deposition of amyloid-β (Aβ) peptides is the most important pathophysiological hallmark of AD. Oxidative stress induced by the generation of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e702b7c84c2b81b473d78543a0efa70
https://doi.org/10.1016/j.freeradbiomed.2021.05.035
https://doi.org/10.1016/j.freeradbiomed.2021.05.035
Publikováno v:
Applied Magnetic Resonance. 52:1017-1029
A portable and compact electron paramagnetic resonance (EPR) imaging magnet was developed for building a 750 MHz EPR imaging system. To realize low-cost fabrication, it was shown that the magnetic homogeneity required for redox EPR imaging using nitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f7067fa37a1c47e142d6f4bf5966c81
https://doi.org/10.1007/s00723-020-01256-4
https://doi.org/10.1007/s00723-020-01256-4
Publikováno v:
Chemical and Pharmaceutical Bulletin. 66:887-891
The drug-nitroxide radical hybrid-compound 7-N-((2,2,5,5-tetramethylpyrrolidine-1-yloxy(PROXYL))-3-yl-methyl)theophylline (3) was synthesized by coupling 7-N-tosyltheophylline with 3-hydroxymethyl-PROXYL, HMP). The stability of 3 relative to that of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caf9aee460e80729575471f298be39fa
https://doi.org/10.1248/cpb.c18-00333
https://doi.org/10.1248/cpb.c18-00333
Publikováno v:
Journal of Magnetic Resonance. 284:48-58
This paper describes the development of a digital console for three-dimensional (3D) continuous wave electron paramagnetic resonance (CW-EPR) imaging of a small animal to improve the signal-to-noise ratio and lower the cost of the EPR imaging system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130e228ba5a506f7c739ff0ef96533dc
https://doi.org/10.1016/j.jmr.2017.09.008
https://doi.org/10.1016/j.jmr.2017.09.008
Autor:
Akihiro Matsumura, Tatsuo Manabe, Naotoshi Iwahara, Miho C. Emoto, Kazuki Yokokawa, Syuuichirou Suzuki, Takashi Matsushita, Hiromi Suzuki, Shun Shimohama, Hideo Sato-Akaba, Hirotada Fujii, Shin Hisahara, Taro Saito, Jun Kawamata
Publikováno v:
Free radical biologymedicine. 145
Alzheimer's disease (AD) is a common neurodegenerative disease that progressively impairs memory and cognition. Deposition of amyloid-β (Aβ) peptides is the most important pathophysiological hallmark of AD. Oxidative stress induced by generation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2381d28c26a7f0dd2460b255674f6ad
https://pubmed.ncbi.nlm.nih.gov/31536772
https://pubmed.ncbi.nlm.nih.gov/31536772
Autor:
Hirotada Fujii, Naotoshi Iwahara, Hiromi Suzuki, Taro Saito, Takashi Matsushita, Kazuki Yokokawa, Akihiro Matsumura, Tatsuo Manabe, Miho C. Emoto, Syuuichirou Suzuki, Shun Shimohama, Jun Kawamata, Mai Fujikura, Shin Hisahara
Publikováno v:
Journal of Alzheimer's disease : JAD. 67(3)
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases responsible for progressive dementia. Deposition of amyloid-β (Aβ) in the brain is the most important pathophysiological hallmark of AD. In addition, recent evidence indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c86c4d1edf99c5f11e17c703b6941bf
https://pubmed.ncbi.nlm.nih.gov/30714961
https://pubmed.ncbi.nlm.nih.gov/30714961
Publikováno v:
Magnetic Resonance in Chemistry. 54:705-711
Theranostic probes provide both therapeutic and diagnostic imaging capabilities in one molecule and show significant promise for use in magnetic resonance imaging (MRI) examinations. The present study describes for the first time the synthesis and ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01ef18087414e6c805505a28a04dd363
https://doi.org/10.1002/mrc.4431
https://doi.org/10.1002/mrc.4431
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1509-1513
The hybrid compounds 1-5 comprised of five nitroxides with ibuprofen were synthesized and their reduction rate for ascorbic acid (AsA) and methyl radicals were measured in comparison with 3-hydroxy-tetramethylpyrrolidine-1-oxyl (PROXYL) 6. The rate c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8148990de8548bd9fe30d56735c725bb
https://doi.org/10.1248/cpb.c16-00347
https://doi.org/10.1248/cpb.c16-00347
Publikováno v:
Neuroscience Letters. 608:40-44
Much evidence supports the idea that oxidative stress is involved in the pathogenesis of epilepsy, and therapeutic interventions with antioxidants are expected as adjunct antiepileptic therapy. The aims of this study were to non-invasively obtain spa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07a5f5ac590536282c2c414bf88dce8
https://doi.org/10.1016/j.neulet.2015.10.008
https://doi.org/10.1016/j.neulet.2015.10.008