Zobrazeno 1 - 10
of 28
pro vyhledávání: '"HIROSHI NAGOSHI"'
Autor:
Chen Hui, Masao Sasabe, Kaoru Yamada, Noriko Yagi, Hiroshi Nagoshi, Masao Omata, Tsuneaki Sugimoto, Atsuo Goto
Publikováno v:
Japanese Heart Journal. 40:209-225
To investigate the relationships between the activity in potential operated Ca2+ channels (POC), blood pressure, and endothelium in hypertension, we tested the contractile responses to a Ca2+ channel agonist Bay K 8644 (BAY K) in aorta from deoxycort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca1b7ba22c3b3246ace376acb79be4d
https://doi.org/10.1536/jhj.40.209
https://doi.org/10.1536/jhj.40.209
Autor:
Atsushi Numabe, Nobuhito Hirawa, Tomoko Gomi, Toshio Ikeda, Masao Omata, Hiroshi Nagoshi, Yoshio Uehara, Atsuo Goto, Yukari Kawabata, Hideyuki Negoro, Satoshi Fujiwara
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 3:327-335
Background: The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is a new genetic model of non-insulin-dependent diabetes mellitus (NIDDM). We investigated whether angiotensin inhibition influences the onset of NIDDM and brings about a regression of ren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5928b1f30f5194d54cec8a048b0f7745
https://doi.org/10.1177/107424849800300408
https://doi.org/10.1177/107424849800300408
Autor:
Kazuya Kikuchi, Yasunobu Hirata, Naoki Nakatsubo, Hirotatsu Kojima, Tetsuo Nagano, Yutaka Kirino, Hiroshi Nagoshi, Shigenori Kawahara
Publikováno v:
Analytical Chemistry. 70:2446-2453
Nitric oxide is a gaseous, free radical which plays a role as an intracellular second messenger and a diffusable intercellular messenger. To obtain direct evidence for NO functions in vivo, we have designed and synthesized diaminofluoresceins (DAFs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad3a84b2375f02c7d84c0f24039546e
https://doi.org/10.1021/ac9801723
https://doi.org/10.1021/ac9801723
Autor:
Yoshio Uehara, Teruhiko Toyo-oka, Fumihiko Kanai, Atsuo Goto, Hiroyasu Esumi, Tsutomu Ogura, Takao Shimizu, Masao Omata, Shin Maeda, Hiroshi Nagoshi
Publikováno v:
Circulation Research. 82:204-209
Abstract —Vascular smooth muscle cells (VSMCs) as well as macrophages have been shown to generate a substantial amount of NO in inflammatory vascular lesions. Prostaglandin (PG) D 2 (PGD 2 ) is produced by inflammatory cells, including mast cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48ef8532accec842399ce424eb26551
https://doi.org/10.1161/01.res.82.2.204
https://doi.org/10.1161/01.res.82.2.204
Publikováno v:
Hypertension. 30:94-98
Abstract A major biologically active endogenous digitalis-like factor in the mammalian body may be an isomer of ouabain (ouabainlike compound, OLC). However, the exact role of OLC in sodium homeostasis is still unclear, and acute isotonic volume expa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc28f51222eb67c66e9a3098be55946
https://doi.org/10.1161/01.hyp.30.1.94
https://doi.org/10.1161/01.hyp.30.1.94
Autor:
Yoshio Uehara, Yasunobu Hirata, Atsuo Goto, Masao Omata, Kenjiro Kimura, Akihiro Ishiyama, Keiichiro Atarashi, Kaoru Yamada, Hiroshi Nagoshi, Mayumi Minami
Publikováno v:
American Journal of Hypertension. 10:337-340
The established associations between blood pressure (BP) and electrolytes are mostly based on either dietary intake or urinary excretion data. We measured office BP, ambulatory BP (ABP) using the automated oscillometric ABPM-630 device, and plasma el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb5d57eb98c54e97b970cb402569213
https://doi.org/10.1016/s0895-7061(96)00348-2
https://doi.org/10.1016/s0895-7061(96)00348-2
Autor:
Yoshio Uehara, Yukari Kawabata, Masao Omata, Teruhiko Toyo-oka, Atsushi Numabe, Tomoko Gomi, Hiroshi Nagoshi, Atsuo Goto, Nobuhito Hirawa, Toshio Ikeda
Publikováno v:
Hypertension Research. 20:193-199
Serum N-acetyl-beta-D-glucosaminidase activity (NAG) is a possible predictor of vascular injury in hypertension. We assessed whether the activity of this enzyme reflects vascular damage in a genetic rat model of non-insulin-dependent diabetes mellitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00703dac8bad15a23f02ecc7f2a393af
https://doi.org/10.1291/hypres.20.193
https://doi.org/10.1291/hypres.20.193
Autor:
Atsushi Numabe, Nobuhito Hirawa, Yukari Kawabata, Hiroshi Nagoshi, Teruhiko Toyo-oka, Tomoko Gomi, Masao Omata, Yoshio Uehara, Atsuo Goto, Hiroshi Kaneko
Publikováno v:
American Journal of Hypertension. 8:1189-1199
We investigated the effects of the adenosine type-1 receptor antagonist FK-838 on salt-induced hypertension in Dahl-Sea salt-sensitive (Dahl S) rats. Dahl S rats fed a high-salt (4% NaCl) diet for 4 weeks were treated with FK-838 or hydrochlorothiazi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff5bce2c44260bf09850103c1b3a500
https://doi.org/10.1016/0895-7061(95)00253-7
https://doi.org/10.1016/0895-7061(95)00253-7
Autor:
Kuniko Sakurai, Shigenori Kawahara, Kazuya Kikuchi, Tetsuo Nagano, Yasunobu Hirata, Hirotatsu Kojima, Hiroshi Nagoshi, Yutaka Kirino
Publikováno v:
ChemInform. 29
Endogenous nitric oxide (NO) appears to modulate many physiological and pathophysiological processes. In order to obtain direct evidence for NO functions in vivo, we have developed 4,5-diaminofluorescein (DAF-2) as a novel fluorescent indicator for N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a3fca20b53d259f78d69fd721757e4c
https://doi.org/10.1002/chin.199833221
https://doi.org/10.1002/chin.199833221
Autor:
Hiroshi Nagoshi, Naoki Nakatsubo, Hirotatsu Kojima, Yasunobu Hirata, Takaaki Akaike, Tetsuo Nagano, Yasuteru Urano, Kuniko Sakurai, Kazuya Kikuchi, Tsunehiko Higuchi, Hiroshi Maeda
Publikováno v:
Biologicalpharmaceutical bulletin. 21(12)
A specific and sensitive detection method for nitric oxide (NO) in living cells and tissue culture systems is required in the search for novel NO synthase (NOS) inhibitors. We have improved a fluorometric determination with 2,3-diaminonaphthalene (DA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a156d87bd6bc019f4bccde37e492a6
https://pubmed.ncbi.nlm.nih.gov/9881632
https://pubmed.ncbi.nlm.nih.gov/9881632