Zobrazeno 1 - 10
of 359
pro vyhledávání: '"HIRONORI HAYASHI"'
Publikováno v:
Biodiversity Data Journal, Vol 12, Iss , Pp 1-9 (2024)
The Ariake catfish, Tachysurus aurantiacus, is a freshwater fish endemic to Kyushu Island, Japan. However, these catfish are now endangered owing to environmental changes. Despite their status, there is scant quantitative research on the Ariake catfi
Externí odkaz:
https://doaj.org/article/699e95f43fe04751adff48ade1155555
Autor:
Kazushige Hirata, Aoi Takahara, Satoshi Suzuki, Shumei Murakami, Kumi Kawaji, Akie Nishiyama, Mina Sasano, Mariko Shoji-Ueno, Emiko Usui, Kazutaka Murayama, Hironori Hayashi, Shinya Oishi, Eiichi N. Kodama
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108961- (2024)
Summary: Despite effective vaccines, measles virus (MeV) outbreaks occur sporadically. Therefore, developing anti-MeV agents remains important for suppressing MeV infections. We previously designed peptide-based MeV fusion inhibitors, M1 and M2, that
Externí odkaz:
https://doaj.org/article/4b8ecf24de4c4d94bb5037e933b019ed
Autor:
Nobuyo Higashi-Kuwata, Kohei Tsuji, Hironori Hayashi, Haydar Bulut, Maki Kiso, Masaki Imai, Hiromi Ogata-Aoki, Takahiro Ishii, Takuya Kobayakawa, Kenta Nakano, Nobutoki Takamune, Naoki Kishimoto, Shin-ichiro Hattori, Debananda Das, Yukari Uemura, Yosuke Shimizu, Manabu Aoki, Kazuya Hasegawa, Satoshi Suzuki, Akie Nishiyama, Junji Saruwatari, Yukiko Shimizu, Yoshikazu Sukenaga, Yuki Takamatsu, Kiyoto Tsuchiya, Kenji Maeda, Kazuhisa Yoshimura, Shun Iida, Seiya Ozono, Tadaki Suzuki, Tadashi Okamura, Shogo Misumi, Yoshihiro Kawaoka, Hirokazu Tamamura, Hiroaki Mitsuya
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Effective antivirals are critical for combatting SARS-CoV-2 infections. Here, the authors develop two orally available small molecules, which specifically inhibit the activity of the SARS-CoV-2 main protease and potently block the infectivity and rep
Externí odkaz:
https://doaj.org/article/0a9319e808d143a0af10cb89193b1a4f
Autor:
Yuko Makino, Chihiro Oe, Kazuya Iwama, Satoshi Suzuki, Akie Nishiyama, Kazuya Hasegawa, Haruka Okuda, Kazushige Hirata, Mariko Ueno, Kumi Kawaji, Mina Sasano, Emiko Usui, Toshiaki Hosaka, Yukako Yabuki, Mikako Shirouzu, Makoto Katsumi, Kazutaka Murayama, Hironori Hayashi, Eiichi N. Kodama
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Structural and biophysical studies of the inhibition of bacterial serine hydroxymethyltransferase (SHMT) by a human SHMT inhibitor used for cancer therapy, (+)-SHIN-1, identify SHMT as a potent antibacterial target.
Externí odkaz:
https://doaj.org/article/efb597c97e904da9b72ba16baed8e329
Autor:
Hironori Hayashi, Koji Amaya, Yuta Fujiwara, Ryutaro Tokai, Yuya Sugimoto, Yu Hashimoto, Makoto Nakura, Shunsuke Kawai, Takahisa Yamaguchi, Atsushi Hirose, Toshifumi Watanabe, Tomoya Tsukada, Masahide Kaji, Kiichi Maeda, Koichi Shimizu
Publikováno v:
Asian Journal of Surgery, Vol 44, Iss 1, Pp 143-146 (2021)
Summary: Background: Postoperative pancreatic fistula (POPF) after pancreatoduodenectomy greatly influences patients' postoperative course. Several evaluation methods have been used to assess the risk of clinically relevant POPF (CR-POPF) after pancr
Externí odkaz:
https://doaj.org/article/f2b532c910da4eeda90dfb582ada7c86
Autor:
Shin-ichiro Hattori, Nobuyo Higashi-Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Haydar Bulut, Debananda Das, Brandon J. Anson, Emma K. Lendy, Yuki Takamatsu, Nobutoki Takamune, Naoki Kishimoto, Kazutaka Murayama, Kazuya Hasegawa, Mi Li, David A. Davis, Eiichi N. Kodama, Robert Yarchoan, Alexander Wlodawer, Shogo Misumi, Andrew D. Mesecar, Arun K. Ghosh, Hiroaki Mitsuya
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, using in vitro assays and structural analysis, the authors characterize the anti-SARS-CoV-2 properties of two small molcules, showing these to bind and target the virus main protease (Mpro), and to exhibit a synergistic antiviral effect when co
Externí odkaz:
https://doaj.org/article/86d3e81f7e794c15baedd9ad9a968412
Autor:
Yuki Ohya, Shintaro Hayashida, Akira Tsuji, Kunitaka Kuramoto, Hidekatsu Shibata, Hiroko Setoyama, Hironori Hayashi, Kazumi Kuriwaki, Masato Sasaki, Masayoshi Iizaka, Osamu Nakahara, Yukihiro Inomata
Publikováno v:
Surgical Case Reports, Vol 6, Iss 1, Pp 1-7 (2020)
Abstract Background Lenvatinib is a novel tyrosine kinase inhibitor that exhibits an antitumor effect on hepatocellular carcinoma (HCC). An established strategy that involves surgery and usage of lenvatinib for advanced HCC remains elusive. Case pres
Externí odkaz:
https://doaj.org/article/1948c884f0c14b94956cf5a40a75bb27
Autor:
Kento Tsukada, Shono Shinki, Akiho Kaneko, Kazuma Murakami, Kazuhiro Irie, Masatoshi Murai, Hideto Miyoshi, Shingo Dan, Kumi Kawaji, Hironori Hayashi, Eiichi N. Kodama, Aki Hori, Emil Salim, Takayuki Kuraishi, Naoya Hirata, Yasunari Kanda, Teigo Asai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Combining genome mining and heterologous expression in a genetically tractable host can lead to bioactive natural products discovery and production. Here, the authors employ this strategy for new decalin-containing diterpenoid pyrenes production by e
Externí odkaz:
https://doaj.org/article/b8d5d9bdb0c848689511d663ed7160bb
Autor:
Ryosuke Sasaki, Yuki Ohya, Shintaro Hayashida, Yuto Maeda, Shuei Murahashi, Sayahito Kumamoto, Akira Tsuji, Hidekatsu Shibata, Kunitaka Kuramoto, Hironori Hayashi, Kazumi Kuriwaki, Masayoshi Iizaka, Osamu Nakahara, Yukihiro Inomata
Publikováno v:
Surgical Case Reports, Vol 6, Iss 1, Pp 1-7 (2020)
Abstract Background Trousseau’s syndrome is a cancer-associated thrombosis. Trousseau’s syndrome with cholangiocarcinoma is a rare condition with poor prognosis. Case presentation A 59-year-old female was admitted to our hospital with abdominal p
Externí odkaz:
https://doaj.org/article/30150907070743bc960cf96198453123
Autor:
Yuka Fujimoto, Yuki Ohya, Shintaro Hayashida, Masayoshi Iizaka, Yuto Maeda, Sayahito Kumamoto, Akira Tsuji, Hidekatsu Shibata, Kunitaka Kuramoto, Hironori Hayashi, Osamu Nakahara, Shinjiro Tomiyasu, Yukihiro Inomata
Publikováno v:
Surgical Case Reports, Vol 6, Iss 1, Pp 1-4 (2020)
Abstract Background Transomental hernias are a rare type of internal hernia. We report two cases of successful cases of laparoscopic repair. One required laparotomy due to concern for intestinal viability. Case presentation The first patient was a 67
Externí odkaz:
https://doaj.org/article/890f936feb5d4841809f2ed569ed4e83