Zobrazeno 1 - 10
of 47
pro vyhledávání: '"HIROMI KAZAMA"'
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0307662 (2024)
Promising outcomes have been reported in elder patients with acute myeloid leukemia (AML) using combined therapy of venetoclax (VEN) and azacytidine (AZA) in recent years. However, approximately one-third of patients appear to be refractory to this t
Externí odkaz:
https://doaj.org/article/41c15908f9024d1583b15934784765e2
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Lysosomes are single-membraned organelles that mediate the intracellular degradation of macromolecules. Various stress can induce lysosomal membrane permeabilization (LMP), translocating intralysosomal components, such as cathepsins, to the
Externí odkaz:
https://doaj.org/article/9e6edb9a15e24e839ad03cd07c6712da
Autor:
Shota Moriya, Hiromi Kazama, Hirotsugu Hino, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazawa
Publikováno v:
PLoS ONE, Vol 18, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/00b3bbb8cd044e8baf6fb9baafd862b3
Autor:
Kana Miyahara, Naoharu Takano, Yumiko Yamada, Hiromi Kazama, Mayumi Tokuhisa, Hirotsugu Hino, Koji Fujita, Edward Barroga, Masaki Hiramoto, Hiroshi Handa, Masahiko Kuroda, Takashi Ishikawa, Keisuke Miyazawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract BRCA1 is a well-studied tumor suppressor involved in the homologous repair of DNA damage, whereas PINK1, a mitochondrial serine/threonine kinase, is known to be involved in mitochondrial quality control. Genetic mutations of PINK1 and Parkin
Externí odkaz:
https://doaj.org/article/2b53b82c6ae5403ab382220048b0b353
Autor:
Hideki Tanaka, Hirotsugu Hino, Shota Moriya, Hiromi Kazama, Masaya Miyazaki, Naoharu Takano, Masaki Hiramoto, Kiyoaki Tsukahara, Keisuke Miyazawa
Publikováno v:
Biochemistry and Biophysics Reports, Vol 22, Iss , Pp - (2020)
Tyrosine kinase inhibitors (TKIs) induce autophagy in many types of cancer cells. We previously reported that gefitinib (GEF) and imatinib (IMA) induce autophagy in epidermal growth factor receptor (EGFR) knock-out A549 and non-BCR-ABL-expressing leu
Externí odkaz:
https://doaj.org/article/c639655190624e29aa720337aaa658e3
Autor:
Kazuhiro Hirasawa, Shota Moriya, Kana Miyahara, Hiromi Kazama, Ayako Hirota, Jun Takemura, Akihisa Abe, Masato Inazu, Masaki Hiramoto, Kiyoaki Tsukahara, Keisuke Miyazawa
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0164529 (2016)
Autophagy, a self-digestive system for cytoplasmic components, is required to maintain the amino acid pool for cellular homeostasis. We previously reported that the macrolide antibiotics azithromycin (AZM) and clarithromycin (CAM) have an inhibitory
Externí odkaz:
https://doaj.org/article/b41545854e87476c9c986f8449422fe2
Autor:
Takuro Nunoura, Yoshihiro Takaki, Hiromi Kazama, Jungo Kakuta, Shigeru Shimamura, Hiroko Makita, Miho Hirai, Masayuki Miyazaki, Ken Takai
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104959 (2014)
Strain Hiromi 1, a sulfur-oxidizing gammaproteobacterium was isolated from a hydrothermal vent chimney in the Okinawa Trough and represents a novel genus that may include a phylogenetic group found as endosymbionts of deep-sea gastropods. The SSU rRN
Externí odkaz:
https://doaj.org/article/4f50127a9ae7435abbed2d95f867e893
Autor:
Naoharu Takano, Masaya Miyazaki, Ayuka Yokota, Mayumi Tokuhisa, Hirotsugu Hino, Keisuke Miyazawa, Masaki Hiramoto, Hiromi Kazama
Publikováno v:
Biochemical and Biophysical Research Communications. 531:256-263
Sequestosome 1 (p62) is a multifunctional adapter protein involved in various physiological functions, such as selective autophagy and oxidative stress response. Hence, aberrant expression and defective regulation of p62 are thought to lead to the on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160821ae947b34edd4b45448a107e921
https://doi.org/10.1016/j.bbrc.2020.07.058
https://doi.org/10.1016/j.bbrc.2020.07.058
Autor:
Hirotsugu Hino, Mayumi Tokuhisa, Keisuke Miyazawa, Masaki Hiramoto, Naoharu Takano, Jun Takemura, Hiroko Kokuba, Masaya Miyazaki, Hiromi Kazama
Publikováno v:
International Journal of Molecular Medicine
The autophagy‑lysosome system allows cells to adapt to environmental changes by regulating the degradation and recycling of cellular components, and to maintain homeostasis by removing aggregated proteins and defective organelles. Cyclin G‑associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f69d2441574965dc8b7821c0aae365
https://doi.org/10.3892/ijmm.2021.5028
https://doi.org/10.3892/ijmm.2021.5028
Autor:
Keitaro Miyake, Naoharu Takano, Hiromi Kazama, Hiroyuki Kikuchi, Masaki Hiramoto, Kiyoaki Tsukahara, Keisuke Miyazawa
Publikováno v:
International journal of oncology. 60(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11fec2695ece008feedddd6be40a42e
https://pubmed.ncbi.nlm.nih.gov/35348191
https://pubmed.ncbi.nlm.nih.gov/35348191