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Akademický článek

Identification of c-Met as a novel target of γ-glutamylcyclotransferase

Autor: Yumiko Saito, Keiko Taniguchi, Hiromi Ii, Mano Horinaka, Susumu Kageyama, Susumu Nakata, Osamu Ukimura, Toshiyuki Sakai

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract γ-Glutamylcyclotransferase (GGCT) is highly expressed in multiple types of cancer tissues and its knockdown suppresses the growth of cancer cells in vitro and in vivo. Although GGCT is a promising target for cancer therapy, the mechanisms u

Externí odkaz: https://doaj.org/article/636da57f22f844ebac82221b2e349830

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Akademický článek

Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy

Autor: Susumu Kageyama, Hiromi Ii, Keiko Taniguchi, Shigehisa Kubota, Tetsuya Yoshida, Takahiro Isono, Tokuhiro Chano, Taku Yoshiya, Kosei Ito, Tatsuhiro Yoshiki, Akihiro Kawauchi, Susumu Nakata

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 7, p 2054 (2018)

γ-Glutamylcyclotransferase (GGCT), which is one of the major enzymes involved in glutathione metabolism, is upregulated in a wide range of cancers—glioma, breast, lung, esophageal, gastric, colorectal, urinary bladder, prostate, cervical, ovarian

Externí odkaz: https://doaj.org/article/bdd94ea001e240d785da75893b9da48e

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Akademický článek

Improved method for the quantification of lysophospholipids including enol ether species by liquid chromatography-tandem mass spectrometry[S]

Autor: James G. Bollinger, Hiromi Ii, Martin Sadilek, Michael H. Gelb

Publikováno v: Journal of Lipid Research, Vol 51, Iss 2, Pp 440-447 (2010)

LC/ESI-MS/MS has been previously demonstrated to be a powerful method to detect and quantify molecular species of glycerophospholipids including lysophospholipids. In this study, we provide an improved pre-mass spectrometry lipid extraction procedure

Externí odkaz: https://doaj.org/article/05b1684e92be40208ecc68899d8bcac3

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Akademický článek

Alleviation of high-fat diet-induced fatty liver damage in group IVA phospholipase A2-knockout mice.

Autor: Hiromi Ii, Naoki Yokoyama, Shintaro Yoshida, Kae Tsutsumi, Shinji Hatakeyama, Takashi Sato, Keiichi Ishihara, Satoshi Akiba

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8089 (2009)

Hepatic fat deposition with hepatocellular damage, a feature of non-alcoholic fatty liver disease, is mediated by several putative factors including prostaglandins. In the present study, we examined whether group IVA phospholipase A(2) (IVA-PLA(2)),

Externí odkaz: https://doaj.org/article/832affb08a8f41bcafefc962d4524fee

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Akademický článek

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Akademický článek

Desert Hedgehog Down-regulation Mediates Inhibition of Proliferation by γ-Glutamylcyclotransferase Knockdown in Murine Glioblastoma Stem Cells.

Autor: MASAYA MORI, HIROMI II, MITSUGU FUJITA, KOZUE NOSE, AYAKO SHIMADA, RISA SHIRAKI, YUHI SONE, CHIAMI MOYAMA, KEIKO TANIGUCHI, SUSUMU NAKATA

Publikováno v: Cancer Genomics & Proteomics (1109-6535); Sep/Oct2024, Vol. 21 Issue 5, p474-484, 11p

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Thiophene Carboxamide Analogs with Long Alkyl Chains Comprising Ethylene Glycol Units Inhibit Glioblastoma Cell Proliferation by Activating AMPK

Autor: Kaito Ohta, Hiromi Ii, Chiami Moyama, Shota Ando, Hisanori Nambu, Susumu Nakata, Naoto Kojima

Publikováno v: Journal of Medicinal Chemistry. 66:6403-6413

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c0cd1cc85abae3987e9391aa279e7d5
https://doi.org/10.1021/acs.jmedchem.3c00474

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The γ-Glutamylcyclotransferase Inhibitor Pro-GA Induces an Antiproliferative Effect Through the Generation of Mitochondrial Reactive Oxygen Species

Autor: Hiromi, Ii, Keiko, Taniguchi, Taku, Yoshiya, Yukie, Nohara, Susumu, Kageyama, Akihiro, Kawauchi, Susumu, Nakata

Publikováno v: Anticancer Research. 42:4311-4317

γ-Glutamylcyclotransferase (GGCT) is up-regulated in a broad range of cancers, including breast cancer, and GGCT inhibition has been shown to be a promising strategy for therapy. Herein, we evaluated the efficacy and mechanism of action of pro-GA, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f0eee97a005405521ca12e51728f71
https://doi.org/10.21873/anticanres.15931

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Myb Repression Mediates Stat5b-knockdown-induced Apoptosis and Inhibits Proliferation of Glioblastoma Stem Cells

Autor: CHIAMI MOYAMA, MITSUGU FUJITA, HITOSHI OKAMOTO, HIROMI II, SUSUMU NAKATA

Publikováno v: Cancer Genomics Proteomics

Background/Aim: Glioblastoma is the most common and aggressive malignant brain tumor in adults, and glioblastoma stem cells (GSCs) contribute to treatment resistance and recurrence. Inhibition of Stat5b in GSCs suppresses cell proliferation and induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d382ef6ff2434cd93e622c5eba1f5a1
https://europepmc.org/articles/PMC9989674/

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