Zobrazeno 1 - 10
of 26
pro vyhledávání: '"HIROKO KOKUBA"'
Publikováno v:
Biochemistry and Biophysics Reports, Vol 11, Iss C, Pp 174-181 (2017)
In this study, we showed that the dual addition of glucosyl ceramide synthase and ceramidase inhibitors to A549 cell culture led to the possibility of ceramide channel formation via endogenous palmitoyl-ceramide accumulation with an increase in chole
Externí odkaz:
https://doaj.org/article/4c3d5b5298a144409535e9b5ad210318
Autor:
Eiji Wada, Megumi Kato, Kaori Yamashita, Hiroko Kokuba, Wen-Chen Liang, Gisèle Bonne, Yukiko K Hayashi
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221512 (2019)
Laminopathies are tissue-selective diseases that affect differently in organ systems. Mutations in nuclear envelopes, emerin (Emd) and lamin A/C (Lmna) genes, cause clinically indistinguishable myopathy called Emery-Dreifuss muscular dystrophy (EDMD)
Externí odkaz:
https://doaj.org/article/a13977dcdb594955b74c7c9871bdbf00
Autor:
Naoharu Takano, Masaki Hiramoto, Yumiko Yamada, Hiroko Kokuba, Mayumi Tokuhisa, Hirotsugu Hino, Keisuke Miyazawa
Publikováno v:
British Journal of Cancer. 128:1838-1849
Background Autophagy plays an important role in tumour cell growth and survival and also promotes resistance to chemotherapy. Hence, autophagy has been targeted for cancer therapy. We previously reported that macrolide antibiotics including azithromy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5b0504bf8c1dce1a1821fa8c6646c1d
https://doi.org/10.1038/s41416-023-02210-4
https://doi.org/10.1038/s41416-023-02210-4
Autor:
Masaki Hiramoto, Keisuke Miyazawa, Akihisa Abe, Hiroko Kokuba, Shota Moriya, Atsuo Takeda, Kiyoaki Tsukahara, Hirotsugu Hino, Naoharu Takano
Publikováno v:
International Journal of Oncology
The proton pump inhibitor lansoprazole (LPZ) inhibits the growth of several cancer cell lines, including A549 and CAL 27. We previously reported that macrolide antibiotics such as azithromycin (AZM) and clarithromycin (CAM) potently inhibit autophagi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8d6f2ada77ba30f64072600dbdd261
http://europepmc.org/articles/PMC7646592
http://europepmc.org/articles/PMC7646592
Autor:
Hirotsugu Hino, Mayumi Tokuhisa, Keisuke Miyazawa, Masaki Hiramoto, Naoharu Takano, Jun Takemura, Hiroko Kokuba, Masaya Miyazaki, Hiromi Kazama
Publikováno v:
International Journal of Molecular Medicine
The autophagy‑lysosome system allows cells to adapt to environmental changes by regulating the degradation and recycling of cellular components, and to maintain homeostasis by removing aggregated proteins and defective organelles. Cyclin G‑associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f69d2441574965dc8b7821c0aae365
https://doi.org/10.3892/ijmm.2021.5028
https://doi.org/10.3892/ijmm.2021.5028
Autor:
Naoharu Takano, Keisuke Miyazawa, Shota Moriya, Hirotsugu Hino, Hiroko Kokuba, Shinsuke Miyazawa
Publikováno v:
Breast Cancer. 27:225-235
Vitamin K2 (VK2) has been reported to induce apoptosis in many types of cancer cells including leukemia. However, there are no precise reports regarding the breast cancer cells. From the stand point of clinical implications of VK2 including chemoprev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac38eb6179ec879fa8c4d0fb11fa371a
https://doi.org/10.1007/s12282-019-01012-y
https://doi.org/10.1007/s12282-019-01012-y
Autor:
Yuta Marumo, Yumi Mizuno, Tetsu Yamaguchi, Natsuko Takano, Takeshi Kajihara, Hiroaki Souma, Shouichirou Mineo, Hiroko Kokuba
Publikováno v:
Placenta. 128:127
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3886dbe6368db197bcc976fd688096ba
https://doi.org/10.1016/j.placenta.2022.08.031
https://doi.org/10.1016/j.placenta.2022.08.031
Autor:
Naoharu Takano, Hiroko Kokuba, Masaki Hiramoto, Shinji Abe, Keisuke Miyazawa, Shota Moriya, Kazutoshi Toriyama, Hiromi Kazama
Publikováno v:
Cancer Science
Cancer cells use autophagy for growth, survival, and cytoprotection from chemotherapy. Therefore, autophagy inhibitors appear to be good candidates for cancer treatment. Our group previously reported that macrolide antibiotics, especially azithromyci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde840fd0a9674f67a68e77b9ddf5602
https://pubmed.ncbi.nlm.nih.gov/34051014
https://pubmed.ncbi.nlm.nih.gov/34051014
Autor:
Hiroko Kokuba, Naoharu Takano, Shin Aizawa, Hirotsugu Hino, Keisuke Miyazawa, Noriyoshi Iriyama, Shota Moriya, Masaki Hiramoto, Hiromi Kazama
Publikováno v:
Cancer Science
In the cell cycle, the G1/S transition is controlled by the cyclin‐dependent kinase (CDK) 4/6‐cyclin D complex. Constitutive activation of CDK4/6 dysregulates G1/S transition, leading to oncogenic transformation. We found that 3 CDK4/6 inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b308660442540ab0c39b3f02871514
https://pubmed.ncbi.nlm.nih.gov/32304130
https://pubmed.ncbi.nlm.nih.gov/32304130
Autor:
Shinsuke, Miyazawa, Shota, Moriya, Hiroko, Kokuba, Hirotsugu, Hino, Naoharu, Takano, Keisuke, Miyazawa
Publikováno v:
Breast cancer (Tokyo, Japan). 27(2)
Vitamin KBreast cancer cell lines were cultured with VK2, and the cytotoxicity and cell death phenotype were examined. The HL-60 leukemia cells were used as a control for VK2-induced apoptosis.VK2 exhibited the cytotoxic effect, especially in triple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b06ea559d7b9fbec801e91478eb1a71e
https://pubmed.ncbi.nlm.nih.gov/31625014
https://pubmed.ncbi.nlm.nih.gov/31625014