Zobrazeno 1 - 10
of 328
pro vyhledávání: '"HIROKI KUNIYASU"'
Autor:
Yoshihiro Miyagawa, Rina Fujiwara-Tani, Ayaka Ikemoto, Rika Sasaki, Ruiko Ogata, Yukiko Nishiguchi, Kei Goto, Isao Kawahara, Takamitsu Sasaki, Hiroki Kuniyasu
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 6472-6488 (2024)
β-Casomorphin-7 (BCM), a breakdown product of milk β-casein, exhibits opioid activity. Opioids are known to affect the immune system, but the effects of BCM on ulcerative colitis (UC) are not clear. We examined the effects of BCM on mucosal immunit
Externí odkaz:
https://doaj.org/article/33a1b6fc90d446aa9c5686fbe5c209e4
Autor:
Yoshihiko M. Sakaguchi, Pattama Wiriyasermkul, Masaya Matsubayashi, Masaki Miyasaka, Nau Sakaguchi, Yoshiki Sahara, Minoru Takasato, Kaoru Kinugawa, Kazuma Sugie, Masahiro Eriguchi, Kazuhiko Tsuruya, Hiroki Kuniyasu, Shushi Nagamori, Eiichiro Mori
Publikováno v:
Journal of Physiological Sciences, Vol 74, Iss 1, Pp 1-18 (2024)
Abstract In humans, uric acid is an end-product of purine metabolism. Urate excretion from the human kidney is tightly regulated by reabsorption and secretion. At least eleven genes have been identified as human renal urate transporters. However, it
Externí odkaz:
https://doaj.org/article/3fd157309e5b4c98b56cb95c4eda789e
Autor:
Ryoichi Nishida, Shota Nukaga, Isao Kawahara, Yoshihiro Miyagawa, Kei Goto, Chie Nakashima, Yi Luo, Takamitsu Sasaki, Kiyomu Fujii, Hitoshi Ohmori, Ruiko Ogata, Shiori Mori, Rina Fujiwara-Tani, Hiroki Kuniyasu
Publikováno v:
Antioxidants, Vol 13, Iss 7, p 821 (2024)
Nutritional interventions are one focus of sarcopenia treatment. As medium-chain fatty acids (MCFAs) are oxidized in the mitochondria and produce energy through oxidative phosphorylation (OXPHOS), they are key parts of nutritional interventions. We i
Externí odkaz:
https://doaj.org/article/e04b54b1bf75479ba11f32cf826be786
Autor:
Takamitsu Sasaki, Rina Fujiwara‐Tani, Shingo Kishi, Shiori Mori, Yi Luo, Hitoshi Ohmori, Isao Kawahara, Kei Goto, Yukiko Nishiguchi, Takuya Mori, Masayuki Sho, Masuo Kondo, Hiroki Kuniyasu
Publikováno v:
Cancer Medicine, Vol 8, Iss 15, Pp 6700-6708 (2019)
Abstract Claudin (CLDN) family comprises of protein that form a tight junction, and is involved in regulating polarity and differentiation of cells. Here, we aimed to investigate the effects of inhibiting CLDN4 in pancreatic ductal carcinomas (PDC).
Externí odkaz:
https://doaj.org/article/f44780c7755b405b8bed9c7cfacb653f
Autor:
Nobuyuki Eura, Takeshi K. Matsui, Joachim Luginbühl, Masaya Matsubayashi, Hitoki Nanaura, Tomo Shiota, Kaoru Kinugawa, Naohiko Iguchi, Takao Kiriyama, Canbin Zheng, Tsukasa Kouno, Yan Jun Lan, Pornparn Kongpracha, Pattama Wiriyasermkul, Yoshihiko M. Sakaguchi, Riko Nagata, Tomoya Komeda, Naritaka Morikawa, Fumika Kitayoshi, Miyong Jong, Shinko Kobashigawa, Mari Nakanishi, Masatoshi Hasegawa, Yasuhiko Saito, Takashi Shiromizu, Yuhei Nishimura, Takahiko Kasai, Maiko Takeda, Hiroshi Kobayashi, Yusuke Inagaki, Yasuhito Tanaka, Manabu Makinodan, Toshifumi Kishimoto, Hiroki Kuniyasu, Shushi Nagamori, Alysson R. Muotri, Jay W. Shin, Kazuma Sugie, Eiichiro Mori
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
The brainstem is a posterior region of the brain, composed of three parts, midbrain, pons, and medulla oblongata. It is critical in controlling heartbeat, blood pressure, and respiration, all of which are life-sustaining functions, and therefore, dam
Externí odkaz:
https://doaj.org/article/df4e7359f1aa4a4388730a853f99d7c0
Autor:
Yoshihiro Miyagawa, Takuya Mori, Kei Goto, Isao Kawahara, Rina Fujiwara-Tani, Shingo Kishi, Takamitsu Sasaki, Kiyomu Fujii, Hitoshi Ohmori, Hiroki Kuniyasu
Publikováno v:
Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-7 (2018)
Abstract Background Oral intake of medium-chain fatty acids (MCFAs) reportedly suppresses the accumulation of visceral fat and has antitumor effects in tumor-bearing animals. MCFAs penetrate the mitochondrial membrane in a carnitine shuttle-independe
Externí odkaz:
https://doaj.org/article/20bfe204372b4b73b817b4d7b2096704
Autor:
Tomonori Sasahira, Nobuhiro Ueda, Kazuhiko Yamamoto, Miyako Kurihara, Sayako Matsushima, Ujjal K Bhawal, Tadaaki Kirita, Hiroki Kuniyasu
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92534 (2014)
Prospero homeobox 1 (Prox1) and forkhead box (FOX) C2 regulate angiogenesis and/or lymphangiogenesis. However, the detailed role and function of Prox1 and FOXC2 in cancer remains controversial. In the present study, we examined the expression of Prox
Externí odkaz:
https://doaj.org/article/74166562ecf94c7383046f3ec0fe49a1
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 1, Iss 1, Pp 50-62 (1999)
We determined whether the implantation of human pancreatic cancer cells into the pancreas of nude mice can be used to select variants with increasing metastatic potential. COLO 357 line fast-growing cells were injected into the spleen or pancreas of
Externí odkaz:
https://doaj.org/article/5921713e20ca47f59f65bc85f677c587
Autor:
Kei Goto, Go Kato, Isao Kawahara, Yi Luo, Koji Obata, Hiromi Misawa, Tatsuya Ishikawa, Hiroki Kuniyasu, Junich Nabekura, Miyako Takaki
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54814 (2013)
One of the challenges of using imaging techniques as a tool to study cellular physiology has been the inability to resolve structures that are not located near the surface of the preparation. Nonlinear optical microscopy, in particular two photon-exc
Externí odkaz:
https://doaj.org/article/aeae729ec1ae45ea9b23809fa808ab6c
Autor:
Hiroki Kuniyasu, Tomonori Sasahira, Ujjal K. Bhawal, Yoshitomo Chihara, Miyako Kurihara, Kazuhiko Yamamoto, Tadaaki Kirita
Publikováno v:
Oncology Reviews, Vol 5, Iss 1 (2011)
Angiogenesis and lymphangiogenesis are the vital factors in tumor progression and metastasis. In this review, we show that high-mobility group box 1 (HMGB1) is responsible for both angiogenesis and lymphangiogenesis in oral squamous cell carcinoma (O
Externí odkaz:
https://doaj.org/article/4da5c979a4f740b8b4dbab6c82ec7c41