Zobrazeno 1 - 10
of 50
pro vyhledávání: '"HIROCHIKA KOMAI"'
Autor:
Thomas S. McDowell, Hirochika Komai
Publikováno v:
Anesthesiology. 94:1089-1095
Background Local anesthetic actions on the K+ channels of dorsal root ganglion (DRG) and dorsal horn neurons may modulate sensory blockade during neuraxial anesthesia. In dorsal horn neurons, local anesthetics are known to inhibit transient but not s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f74503ab2cdc9240239c756ae230619
https://doi.org/10.1097/00000542-200106000-00025
https://doi.org/10.1097/00000542-200106000-00025
Autor:
Hirochika Komai, Andrew J. Lokuta
Publikováno v:
Anesthesiology. 90:835-843
Background Although various local anesthetics can cause histologic damage to skeletal muscle when injected intramuscularly, bupivacaine appears to have an exceptionally high rate of myotoxicity. Research has suggested that an effect of bupivacaine on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db867819d7c41874378ba84ae274a3a7
https://doi.org/10.1097/00000542-199903000-00027
https://doi.org/10.1097/00000542-199903000-00027
Publikováno v:
Journal of Molecular and Cellular Cardiology. 27:2543-2550
We tested the possibility that inhibition of Ca 2+ release from the sarcoplasmic reticulum decreases the transsarcolemmal Ca 2+ efflux and results in an increased sarcoplasmic reticulum Ca 2+ content. We used procaine to inhibit sarcoplasmic reticulu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e152728ebc3b954aec1848ce579ced
https://doi.org/10.1006/jmcc.1995.0041
https://doi.org/10.1006/jmcc.1995.0041
Autor:
Hirochika Komai, Ben F. Rusy
Publikováno v:
Anesthesiology. 81:946-952
Background While thiopental is known to inhibit the myocardial transsarcolemmal influx of Ca2+, the effect of thiopental on sarcoplasmic reticular Ca2+ release has not been characterized. Methods Isolated papillary muscles of rabbits were used. We me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e20d6c16e70a2f3058b1d9743506df
https://doi.org/10.1097/00000542-199410000-00021
https://doi.org/10.1097/00000542-199410000-00021
Autor:
Ben F. Rusy, Hirochika Komai
Publikováno v:
Cardiovascular Research. 27:801-806
Objective: The aim was to characterise the influence of a decrease in transsarcolemmal calcium influx on the calcium content of the sarcoplasmic reticulum and on the force of postrest contraction, which is largely activated by calcium released from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4b74351abf857d4bf8a1d70d7593e2
https://doi.org/10.1093/cvr/27.5.801
https://doi.org/10.1093/cvr/27.5.801
Publikováno v:
Acta Anaesthesiologica Scandinavica. 35:373-379
To see if the known properties of thiopental of reducing Ca2+ and K+ fluxes across the myocardial sarcolemma account for its arrhythmogenic action, we have evaluated the effect of the anesthetic on spontaneous contractile activity induced in isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b24415c455a3e06dcd57ca5a33333ac
https://doi.org/10.1111/j.1399-6576.1991.tb03313.x
https://doi.org/10.1111/j.1399-6576.1991.tb03313.x
Autor:
Thomas S. McDowell, Hirochika Komai
Neuraxial analgesia is often provided using a mixture of local anesthetics and opioids. This combination of agents provides better pain relief and is generally associated with fewer side effects than when either drug is given alone. Local anesthetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a765005d0238b81ec33d4873828ac90f
https://europepmc.org/articles/PMC2046215/
https://europepmc.org/articles/PMC2046215/
Autor:
Thomas S. McDowell, Hirochika Komai
Publikováno v:
Neuroscience letters. 380(1-2)
Capsaicin opens the TRPV1 channel, a cation channel that depolarizes and activates nociceptive neurons. Following this initial activation, neurons become desensitized to subsequent applications of capsaicin as well as to other noxious stimuli, a phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990ba64966336ccb8081f7f7c8bfcb30
https://pubmed.ncbi.nlm.nih.gov/15854744
https://pubmed.ncbi.nlm.nih.gov/15854744
Publikováno v:
Anesthesiology. 85(5)
Background When cardiac muscle is stimulated at a high frequency after rest, the peak force increases rapidly at first and then slowly. The slow phase reflects Ca2+ accumulation dependent on an increase in intracellular Na+ activity. The positive ino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18540e1f13a3d6e9f6cf5a2b8fdd16b
https://pubmed.ncbi.nlm.nih.gov/8916832
https://pubmed.ncbi.nlm.nih.gov/8916832
Autor:
Ben F. Rusy, Hirochika Komai
Publisher Summary In this chapter the results of the experiments using Ni2+ suggest that, in heart muscle beating at close to physiological rates, the inhibition of transsarcolemmal Ca2+ influx inhibits Ca2+-induced release of sarcoplasmic reticular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79e7a274a9eac70c44034d1f0f9fb6db
https://doi.org/10.1016/s1054-3589(08)60618-3
https://doi.org/10.1016/s1054-3589(08)60618-3