Zobrazeno 1 - 10
of 79
pro vyhledávání: '"HIPK"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Homeodomain-interacting protein kinases (Hipks) regulate cell proliferation, apoptosis, and tissue development. Overexpression of Hipk in Drosophila causes tumorigenic phenotypes in larval imaginal discs. We find that depletion of Salt-inducible kina
Externí odkaz:
https://doaj.org/article/d48cda3928dd48ef8ed15d5d4d0474a0
Publikováno v:
eLife, Vol 8 (2019)
Cancer cells usually exhibit aberrant cell signaling and metabolic reprogramming. However, mechanisms of crosstalk between these processes remain elusive. Here, we show that in an in vivo tumor model expressing oncogenic Drosophila Homeodomain-intera
Externí odkaz:
https://doaj.org/article/8aad676db13d443c83a547bbce43d4b8
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1862 (2021)
Developmental growth and patterning are regulated by an interconnected signalling network of several pathways. In Drosophila, the Warts (Wts) kinase, a component of the Hippo signalling pathway, plays an essential role in regulating transcription and
Externí odkaz:
https://doaj.org/article/f02a543a586b4bc889934dcbb86a08b7
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 1 (2018)
Aberrations in signaling pathways that regulate tissue growth often lead to tumorigenesis. Homeodomain-interacting protein kinase (Hipk) family members are reported to have distinct and contradictory effects on cell proliferation and tissue growth. F
Externí odkaz:
https://doaj.org/article/6b5909b94b8a45f3ab66aec0c9dff1a8
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 8, p 1931 (2019)
The Drosophila homeodomain-interacting protein kinase (Hipk) is the fly representative of the well-conserved group of HIPKs in vertebrates. It was initially found through its characteristic interactions with homeodomain proteins. Hipk is involved in
Externí odkaz:
https://doaj.org/article/bcdd3398f71d4a63acabe78e758095c0
Akademický článek
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Autor:
Yi-Yun Chen, Kay-Hooi Khoo, Esther M. Verheyen, Ta-Wei Liu, David J. Vocadlo, Kenneth Kin Lam Wong, Jessica M Parker, Donald A. R. Sinclair
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance O-GlcNAc transferase (OGT) transfers the sugar O-GlcNAc to serine and threonine residues of target proteins, a process known as O-GlcNAcylation. Using Drosophila as an animal model, we identify the protein kinase Hipk as a target protein
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Both functional and dysfunctional mitochondria are known to underlie tumor progression. Here, we establish use of the proto-oncogene Drosophila Homeodomain-interacting protein kinase (Hipk) as a new tool to address this paradox. We find that, in Hipk
Akademický článek
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