Zobrazeno 1 - 10
of 256
pro vyhledávání: '"HIF2α"'
Autor:
Huiying Liu, Pengcheng Wang, Feng Xu, Qixing Nie, Sen Yan, Zhipeng Zhang, Yi Zhang, Changtao Jiang, Xiaomei Qin, Yanli Pang
Publikováno v:
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract Metabolic abnormalities contribute to the pathogenesis of obesity and its complications. Yet, the understanding of the interactions between critical metabolic pathways that underlie obesity remains to be improved, in part owing to the lack o
Externí odkaz:
https://doaj.org/article/8e96f49a712841db984d5c36492a2d35
Autor:
Daniela Magliulo, Matilde Simoni, Carolina Caserta, Cristina Fracassi, Serena Belluschi, Kety Giannetti, Raffaella Pini, Ettore Zapparoli, Stefano Beretta, Martina Uggè, Eleonora Draghi, Federico Rossari, Nadia Coltella, Cristina Tresoldi, Marco J Morelli, Raffaella Di Micco, Bernhard Gentner, Luca Vago, Rosa Bernardi
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-19 (2023)
Abstract One of the defining features of acute myeloid leukemia (AML) is an arrest of myeloid differentiation whose molecular determinants are still poorly defined. Pharmacological removal of the differentiation block contributes to the cure of acute
Externí odkaz:
https://doaj.org/article/2d1702404ed248f580d807aa7c1fabee
Autor:
Yanmei Quan, Jun Dai, Sian Zhou, Lingyi Zhao, Lixing Jin, Yijing Long, Siwei Liu, Yanqin Hu, Yue Liu, Juping Zhao, Zhide Ding
Publikováno v:
FEBS Open Bio, Vol 13, Iss 4, Pp 638-654 (2023)
Clear cell renal cell carcinoma (ccRCC), the most common malignant subtype of renal cell carcinoma, is characterized by the accumulation of lipid droplets in the cytoplasm. RNASET2 is a protein coding gene with a low expression level in ovarian cance
Externí odkaz:
https://doaj.org/article/f1bdb22f8aba492399277207029550c6
Publikováno v:
Journal of Pathology and Translational Medicine, Vol 57, Iss 2, Pp 113-122 (2023)
Background Gallbladder cancer (GBC) is usually detected in advanced stages with a low 5-year survival rate. Delta-like ligand 4 (DLL4), vascular endothelial growth factor (VEGF), and hypoxia-inducible factor-2alpha (HIF2α) have been studied for thei
Externí odkaz:
https://doaj.org/article/007761423497425680dee7b6fed4a9da
Autor:
Maddalena Sbaffone, Marie-Lise Jaffrain-Rea, Lucia Cappabianca, Francesca Carbonara, Francesca Gianno, Tiziana Feola, Marianna Ruggieri, Veronica Zelli, Rita Maccarone, Stefano Guadagni, Marco Clementi, Antonietta Arcella, Vincenzo Esposito, Giulia Carozza, Ilaria Martelli, Antonietta Rosella Farina, Andrew Reay Mackay
Publikováno v:
Biology, Vol 13, Iss 3, p 171 (2024)
Pituitary neuroendocrine tumors (PitNETs) are generally benign but comprise an aggressive, invasive, therapy-resistant, metastatic subset, underpinning a need for novel therapeutic targets. PitNETs exhibit low mutation rates but are associated with c
Externí odkaz:
https://doaj.org/article/16394a057224452daab107042774ee82
Autor:
Yang Kong, Pei‐Kang Liu, Yao Li, Nicholas D Nolan, Peter M J Quinn, Chun‐Wei Hsu, Laura A Jenny, Jin Zhao, Xuan Cui, Ya‐Ju Chang, Katherine J Wert, Janet R Sparrow, Nan‐Kai Wang, Stephen H Tsang
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp 1-20 (2023)
Abstract Iron accumulation causes cell death and disrupts tissue functions, which necessitates chelation therapy to reduce iron overload. However, clinical utilization of deferoxamine (DFO), an iron chelator, has been documented to give rise to syste
Externí odkaz:
https://doaj.org/article/dad16b5228fa4f2aae01a11f4bb1e21e
Akademický článek
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Akademický článek
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Akademický článek
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Publikováno v:
Biomedicines, Vol 11, Iss 11, p 2992 (2023)
Excessive erythrocytosis (EE) is a preclinical form of chronic mountain sickness (CMS). The dysregulation of iron metabolism in high-altitude hypoxia may induce EE. The intestinal hypoxia-inducible factor 2 alpha (HIF2a) regulates the genes involved
Externí odkaz:
https://doaj.org/article/4a19803814dd4208b8a1254ce739fcce