Zobrazeno 1 - 10
of 1 583
pro vyhledávání: '"HIF1α"'
Autor:
Ichiro Kawahara, Hirofumi Yoshino, Wataru Fukumoto, Junya Arima, Saeki Saito, Gang Li, Ikumi Fukuda, Akihiko Mitsuke, Takashi Sakaguchi, Satoru Inoguchi, Ryosuke Matsushita, Masayuki Nakagawa, Shuichi Tatarano, Yasutoshi Yamada, Hideki Enokida
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2196-2211 (2024)
Gemcitabine plus cisplatin (GC) combination chemotherapy is the primary treatment for advanced bladder cancer (BC) with unresectable or metastatic disease. However, most cases develop resistance to this therapy. We investigated whether drug resistanc
Externí odkaz:
https://doaj.org/article/c2d8257116da49f8983df134c431822c
Autor:
Ashutosh Singh, Donghang Cheng, Jyothishmathi Swaminathan, Yanwen Yang, Yan Zheng, Nancy Gordon, Vidya Gopalakrishnan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The RE1 silencing transcription factor (REST) is a driver of sonic hedgehog (SHH) medulloblastoma genesis. Our previous studies showed that REST enhances cell proliferation, metastasis and vascular growth and blocks neuronal differentiation
Externí odkaz:
https://doaj.org/article/1ed74e9c2f9940068158fa62483d53f1
Autor:
Janice Raabe, Ilka Wittig, Patrick Laurette, Konstantina Stathopoulou, Theresa Brand, Thomas Schulze, Birgit Klampe, Ellen Orthey, Alfredo Cabrera-Orefice, Jana Meisterknecht, Ellen Thiemann, Sandra D. Laufer, Aya Shibamiya, Marina Reinsch, Sigrid Fuchs, Jennifer Kaiser, Jiaqi Yang, Simonida Zehr, Kinga M. Wrona, Kristina Lorenz, Robert Lukowski, Arne Hansen, Ralf Gilsbach, Ralf P. Brandes, Bärbel M. Ulmer, Thomas Eschenhagen, Friederike Cuello
Publikováno v:
Redox Biology, Vol 77, Iss , Pp 103352- (2024)
Human induced pluripotent stem cells (hiPSCs) are an invaluable tool to study molecular mechanisms on a human background. Culturing stem cells at an oxygen level different from their microenvironmental niche impacts their viability. To understand thi
Externí odkaz:
https://doaj.org/article/d9714c52734f4b87ab939aa73d9d8316
Autor:
Andrea Scafidi, Frida Lind-Holm Mogensen, Eleonora Campus, Alexandros Pailas, Katrin Neumann, Nathalie Legrave, François Bernardin, Sandro L. Pereira, Paul M.A. Antony, Nathalie Nicot, Michel Mittelbronn, Anne Grünewald, Petr V. Nazarov, Aurélie Poli, Eric Van Dyck, Alessandro Michelucci
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37792- (2024)
Background: Epidemiological studies suggest that metformin reduces the risk of developing several types of cancer, including gliomas, and improves the overall survival in cancer patients. Nevertheless, while the effect of metformin on cancer cells ha
Externí odkaz:
https://doaj.org/article/b221e5f5aea84d3ab983d6c758a224c5
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Bawei Chenxiang Wan (BCW) is among the most effective and widely used therapies for coronary heart disease and angina pectoris in Tibet. However, whether it confers protection through a right-ventricle (RV) myocardial metabolic me
Externí odkaz:
https://doaj.org/article/c95e793261f1414fa012ff25bc121064
Autor:
Yiting Geng, Xiao Zheng, Dachuan Zhang, Shanshan Wei, Jun Feng, Wei Wang, Luo Zhang, Changping Wu, Wenwei Hu
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract Epidermal growth factor receptor (EGFR)-targeted therapy is an important treatment for RAS wild-type metastatic colorectal cancer (mCRC), but the resistance mechanism remains unclear. Here, the differential expression of circRNAs between Cet
Externí odkaz:
https://doaj.org/article/ee4d73e8c2ab48c68bc10be1ac025155
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-16 (2024)
Abstract Background Yu Linzhu (YLZ) is a classical Chinese traditional formula, which has been used for more than 600 years to regulate menstruation to help pregnancy. However, the mechanism of modern scientific action of YLZ needs to be further stud
Externí odkaz:
https://doaj.org/article/46ca2fbe458446d0b2a7c17d20b6e4ad
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-16 (2024)
Abstract Background Breast cancer, the most prevalent cancer in women worldwide, faces treatment challenges due to drug resistance, posing a serious threat to patient survival. The present study aimed to identify the key molecules that drive drug res
Externí odkaz:
https://doaj.org/article/27e0d55456c04f368ef38a452c69308c
Autor:
Fei Luo, Mingda Zhang, Bowen Sun, Chenxin Xu, Yi Yang, Yingwen Zhang, Shanshan Li, Guoyu Chen, Ceshi Chen, Yanxin Li, Haizhong Feng
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-21 (2024)
Abstract Background Cancer stem-like cell is a key barrier for therapeutic resistance and metastasis in various cancers, including breast cancer, yet the underlying mechanisms are still elusive. Through a genome-wide lncRNA expression profiling, we i
Externí odkaz:
https://doaj.org/article/d683b299b311482783d9ef43f7f2af04
Autor:
Jaehyeon Jeong, Byeong-Hee Kang, Sangmin Ju, Na Yeon Park, Deukyeong Kim, Ngoc Thi Bao Dinh, Jeongho Lee, Chang Yun Rhee, Dong-Hyung Cho, Hangeun Kim, Dae Kyun Chung, Heeyoun Bunch
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Hypoxic responses have been implicated in critical pathologies, including inflammation, immunity, and tumorigenesis. Recently, efforts to identify effective natural remedies and health supplements are increasing. Previous studies have report
Externí odkaz:
https://doaj.org/article/4b53fac9831d4d44b1b41a04ff70d618