Zobrazeno 1 - 10
of 9 834
pro vyhledávání: '"HIF-1"'
Autor:
Jin Fang, Ying Wang, Chen Li, Weixiao Liu, Wannan Wang, Xuewei Wu, Yang Wang, Shuixing Zhang, Jing Zhang
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2565-2579 (2024)
Cervical cancer remains a significant global public health concern, often exhibits cisplatin resistance in clinical settings. Hypoxia, a characteristic of cervical cancer, substantially contributes to cisplatin resistance. To evaluate the therapeutic
Externí odkaz:
https://doaj.org/article/49f0d59cf7c744d195449270f5ea521a
Autor:
Haihua Liu, Zhijian Wang, Yanjun Li, Qian Chen, Sijia Jiang, Yue Gao, Jing Wang, Yali Chi, Jie Liu, Xiaoli Wu, Qiong Chen, Chaoqun Xiao, Mei Zhong, Chunlin Chen, Xinping Yang
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Recent studies have shown that several long non-coding RNAs (lncRNAs) in the placenta are associated with preeclampsia (PE). However, the extent to which lncRNAs may contribute to the pathological progression of PE is unclear. Res
Externí odkaz:
https://doaj.org/article/acefd4e979fe414cbf02b4bd87edae56
Autor:
Siyong Peng, Yingbo Guo, Marie Irondelle, Abigail Mazzu, Michel Kahi, Paula Ferreira Montenegro, Frédéric Bost, Nathalie M. Mazure
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-19 (2024)
Abstract Background Prostate cancer (PCa) ranks as the second most prevalent cancer in men, with advanced stages posing significant treatment challenges. Given its solid tumor nature, PCa is highly susceptible to hypoxia, a condition associated with
Externí odkaz:
https://doaj.org/article/49bbf45345e645cfb3a2d6bd3655b6ea
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Fasting is a common dietary intervention known for its protective effects against metabolic and cardiovascular diseases. While its effects are mostly systemic, understanding tissue-specific changes in the heart is crucial for the identification of th
Externí odkaz:
https://doaj.org/article/3d906ab87b6d44ea87b67ce6655a4536
Autor:
Sophie A. Twigger, Blanca Dominguez, Vanesa Porto, Lina Hacker, Anthony J. Chalmers, Ross Breckenridge, Martin Treder, Adam C. Sedgwick, Fernando Dominguez, Ester M. Hammond
Publikováno v:
Redox Biology, Vol 76, Iss , Pp 103326- (2024)
Regions of hypoxia occur in most solid tumours and are known to significantly impact therapy response and patient prognosis. Ag5 is a recently reported silver molecular cluster which inhibits both glutathione and thioredoxin signalling therefore limi
Externí odkaz:
https://doaj.org/article/67a59339aad4476cbe985cd7a0f974ef
Autor:
Shunan Yu, Xiong Shu, Xinyu Wang, Yueyang Sheng, Shan Li, Ying Wang, Yanzhuo Zhang, Jiangfeng Tao, Xu Jiang, Chengai Wu
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e35603- (2024)
Osteoarthritis (OA) is a prevalent chronic degenerative disease that affects the bones and joints, particularly in middle-aged and elderly individuals. It is characterized by progressive joint pain, swelling, stiffness, and deformity. Notably, treatm
Externí odkaz:
https://doaj.org/article/4b88b37238454392a107d68b401d8b26
Publikováno v:
Chinese Medicine, Vol 19, Iss 1, Pp 1-16 (2024)
Abstract Background Shenma Jingfu Granule, a traditional Chinese medicine formula, has been used clinically for the treatment of cerebral circulation insufficiency. However, the mechanism involved in alleviating cerebral ischemia has not yet been ful
Externí odkaz:
https://doaj.org/article/56fdea9ce67845c3940eaa5520f32b36
Autor:
Carlos César Bravo-Reyna, Vladimir Miranda-Galván, Gervith Reyes-Soto, R. Vicuña, Jorge Alanis-Mendizabal, Manuel Escobar-Valderrama, David Arango, Claudia J. Bautista, Victoria Ramírez, Gonzalo Torres-Villalobos
Publikováno v:
World Neurosurgery: X, Vol 25, Iss , Pp 100414- (2025)
Background: Several research studies have been focused on improving the treatment and prognosis of acute spinal cord injury, as part of this initiative we investigated the use of Chetomin to reduce the inflammatory response in this pathology. Methods
Externí odkaz:
https://doaj.org/article/f30ae18f3c4345e69b99468b89fe3974
Autor:
Wenjun Zhang, Chao Guo, Yi Li, Hao Wang, Huabing Wang, Yingying Wang, Tingting Wu, Huinan Wang, Gang Cheng, Jiangwei Man, Siyu Chen, Shengjun Fu, Li Yang
Publikováno v:
Renal Failure, Vol 46, Iss 1 (2024)
Acute kidney injury (AKI) is associated with a high mortality rate. Pathologically, renal ischemia/reperfusion injury (RIRI) is one of the primary causes of AKI, and hypoxia-inducible factor (HIF)-1α may play a defensive role in RIRI. This study ass
Externí odkaz:
https://doaj.org/article/c421972032fa4c5ead796c48ce7ca318
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