Zobrazeno 1 - 10
of 53
pro vyhledávání: '"HIF prolyl-hydroxylase inhibitor"'
Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells
Autor:
Peter A.C. Wing, Thomas P. Keeley, Xiaodong Zhuang, Jeffrey Y. Lee, Maria Prange-Barczynska, Senko Tsukuda, Sophie B. Morgan, Adam C. Harding, Isobel L.A. Argles, Samvid Kurlekar, Marko Noerenberg, Craig P. Thompson, Kuan-Ying A. Huang, Peter Balfe, Koichi Watashi, Alfredo Castello, Timothy S.C. Hinks, William James, Peter J. Ratcliffe, Ilan Davis, Emma J. Hodson, Tammie Bishop, Jane A. McKeating
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109020- (2021)
Summary: COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment, and one important factor to consider is oxygen tension,
Externí odkaz:
https://doaj.org/article/0e81e8390d8b4bff8a888f023b7b0038
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Anemia is a common complication in chronic kidney disease (CKD), and is associated with a reduced quality of life, and an increased morbidity and mortality. The mechanisms involved in anemia associated to CKD are diverse and complex. They include a d
Externí odkaz:
https://doaj.org/article/05428e1b3d6144d4bb9bfb46a5268361
Akademický článek
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Autor:
Yu Tateishi, Shunji Nishide, Katsuyuki Miura, Kazuya Kabei, Masayuki Shiota, Junji Uchida, Tatsuya Nakatani, Shuhei Tomita, Shinji Matsunaga, Mayuko Osada-Oka, Takehiro Yamaguchi
Publikováno v:
Journal of Pharmacological Sciences, Vol 142, Iss 3, Pp 93-100 (2020)
Orally active hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors that stabilize HIF protein and stimulate the production of erythropoietin have been approved to treat renal anemia. Our previous report suggested that HIF-1α dependent fibrog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc98498742c8c66c54d01ba27c7f219
https://doi.org/10.1016/j.jphs.2019.12.002
https://doi.org/10.1016/j.jphs.2019.12.002
Autor:
Yuichi Shinozaki, Masaomi Nangaku, Akira Matsuo, Tetsuhiro Tanaka, Kenji Fukui, Takeshi Wakashima, Hatsue Kobayashi, Yasumasa Komoda
Publikováno v:
American Journal of Physiology-Renal Physiology. 318:F14-F24
Some preceding studies have provided evidence that hypoxia-inducible factor (HIF)-prolyl hydroxylase (PH) inhibitors have therapeutic potential against tubular interstitial fibrosis (TIF). Recently, transformation of renal interstitial fibroblasts (R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2971350726de13a16dec7f8fbbc61fce
https://doi.org/10.1152/ajprenal.00323.2019
https://doi.org/10.1152/ajprenal.00323.2019
Autor:
Ilan Davis, Peter J. Ratcliffe, Alfredo Castello, William James, Jeffrey Y. Lee, Maria Prange-Barczynska, Marko Noerenberg, Jane A. McKeating, Craig Thompson, Senko Tsukuda, Koichi Watashi, Isobel L.A. Argles, Thomas P. Keeley, Sophie B. Morgan, Peter A C Wing, Samvid Kurlekar, Kuan-Ying A. Huang, Xiaodong Zhuang, Timothy S. C. Hinks, Tammie Bishop, Peter Balfe, Emma J. Hodson, Adam Harding
Publikováno v:
Cell Reports
Cell Reports, Vol 35, Iss 3, Pp 109020-(2021)
Cell Reports, Vol 35, Iss 3, Pp 109020-(2021)
COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment and one important factor to consider is oxygen tension, where hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8e53769facfdeba33434aaf01a539d
http://europepmc.org/articles/PMC8020087
http://europepmc.org/articles/PMC8020087
Publikováno v:
Gut Microbes
article-version (VoR) Version of Record
Gut Microbes, Vol 13, Iss 1 (2021)
article-version (VoR) Version of Record
Gut Microbes, Vol 13, Iss 1 (2021)
The gut microbiota is essential for human health. Microbial supply of short-chain fatty acids (SCFAs), particularly butyrate, is a well-established contributor to gut homeostasis and disease resistance. Reaching millimolar luminal concentrations, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68bb1698bba10e6a662811a1c459d39d
https://pubmed.ncbi.nlm.nih.gov/34190032
https://pubmed.ncbi.nlm.nih.gov/34190032
Autor:
Félix Goulet, Nacera Mellal, Liangfu Chen, Mark S Watkins, Elaine Debien, David F. Adams, Roberta A. Thomas, Wei Shi, Kendall S. Frazier, Erding Hu, Luc Durette, Josée Laliberté
Publikováno v:
Toxicologic Pathology. 48:362-378
Daprodustat (GSK1278863) is a hypoxia-inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor in development for treatment of anemia of chronic kidney disease. Daprodustat’s biological activity simulates components of the natural response to hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc4e00a39eddeddab03e7cad46326b2
https://doi.org/10.1177/0192623319880445
https://doi.org/10.1177/0192623319880445
Autor:
I N Gazizov, Anna Yu. Khristichenko, A. A. Zakhariants, Andrey A. Poloznikov, Dmitry M. Hushpulian, Vladimir I. Tishkov, Irina G. Gazaryan, Sergey Nikulin
Publikováno v:
Drug Metabolism Letters. 13:45-52
Background: “Branched tail” oxyquinolines, and adaptaquin in particular, are potent HIF prolyl hydroxylase inhibitors showing promising results in in vivo hemorrhagic stroke models. The further improvement of the potency resulted in identificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496f81b6e9b91599479aa34eb1a7bb8e
https://doi.org/10.2174/1872312813666181129100950
https://doi.org/10.2174/1872312813666181129100950
Autor:
Andrew C. Perkins, Ingrid G. Winkler, Thomas Keech, Marion E. G. Brunck, Whitney Fleming, Gail Walkinshaw, Taichi Matsumoto, Jean-Pierre Levesque, Julie M. Davies, Kavita Bisht, Bianca Nowlan, Graham Magor, Crystal McGirr, Lee A. Flippin
Publikováno v:
Blood Advances. 3:406-418
In normoxia, hypoxia-inducible transcription factors (HIFs) are rapidly degraded within the cytoplasm as a consequence of their prolyl hydroxylation by oxygen-dependent prolyl hydroxylase domain (PHD) enzymes. We have previously shown that hematopoie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723ae274401a19004dd45bd902268a1b
https://doi.org/10.1182/bloodadvances.2018017566
https://doi.org/10.1182/bloodadvances.2018017566