Zobrazeno 1 - 10
of 151
pro vyhledávání: '"HIF, Hypoxia inducible factor"'
Autor:
Hagit Kvitt, Assaf Malik, Smadar Ben-Tabou de-Leon, Eli Shemesh, Maya Lalzar, David F. Gruber, Hanna Rosenfeld, Tuo Shi, Tali Mass, Dan Tchernov
Publikováno v:
Frontiers in Marine Science, Vol 9 (2022)
The current decrease in oceanic dissolved oxygen is a widespread and pressing problem that raises concern as to how marine biota in general, and coral reefs in particular will be affected. However, the molecular response underlying tolerance of coral
Externí odkaz:
https://doaj.org/article/029750d8fb3e40a7bdb18ad07de38d0a
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Guhong injection (GHI) is a drug for ischemic stroke created by combining safflower, a traditional Chinese medicine, and aceglutamide, a Western medicine. In this study, we investigated the curative effect of GHI on cerebral ischemia–reperfusion (I
Externí odkaz:
https://doaj.org/article/9b63f50d74464378a0bde17afea5cb2a
Autor:
Khalil Khalaf, Doris Hana, Jadzia Tin-Tsen Chou, Chandpreet Singh, Andrzej Mackiewicz, Mariusz Kaczmarek
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The tumor microenvironment (TME) is a complex and ever-changing “rogue organ” composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells and extracellular matrix (ECM). These complex components, utilizing both benign an
Externí odkaz:
https://doaj.org/article/f0ddcf318e8f48f7ba81c91c8d6f4875
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The water channel aquaporin 1 (AQP1) has been implicated in tumor progression and metastasis. It is hypothesized that AQP1 expression can facilitate the transmembrane water transport leading to changes in cell structure that promote migration. Its im
Externí odkaz:
https://doaj.org/article/90b726667226422f8de9c1b0c15aa286
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1617 (2020)
Insulin receptor (IR) and IR-related signaling defects have been shown to trigger insulin-resistance in insulin-dependent cells and ultimately to give rise to type 2 diabetes in mammalian organisms. IR expression is ubiquitous in mammalian tissues, a
Externí odkaz:
https://doaj.org/article/37706b4388a6470081611b4772020034
Autor:
Beatrice Foglia, G. Villano, Ramy Younes, Emanuele Albano, Salvatore Sutti, Patrizia Pontisso, Riccardo Autelli, Ignazia Tusa, Naresh Naik Ramavath, Chiara Rosso, Elisabetta Rovida, Elisabetta Bugianesi, Erica Novo, Stefania Cannito, Maurizio Parola, Marina Maggiora, Claudia Bocca
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 459-482 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 459-482 (2022)
Background & Aims Hypoxia and hypoxia-inducible factors (HIFs) are involved in chronic liver disease progression. We previously showed that hepatocyte HIF-2α activation contributed significantly to nonalcoholic fatty liver disease progression in exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a59ab5cb7a1f82eda21068f7059c53
http://europepmc.org/articles/PMC8688724
http://europepmc.org/articles/PMC8688724
Autor:
Joana Pimenta, Ricardo Faria Ribeiro, Marta A. da Silva, Pedro F. Costa, Bruno Pereira, Raquel Almeida
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
The intestinal epithelium has one of the highest turnover rates in the human body, which is supported by intestinal stem cells. Culture models of intestinal physiology have been evolving to incorporate different tissue and microenvironmental elements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8661a21600bd3fd17a49abc2ab2c9775
http://europepmc.org/articles/PMC8688162
http://europepmc.org/articles/PMC8688162
Publikováno v:
Bioactive Materials
Bioactive Materials, Vol 6, Iss 7, Pp 1973-1987 (2021)
Bioactive Materials, Vol 6, Iss 7, Pp 1973-1987 (2021)
The tumor development and metastasis are closely related to the structure and function of the tumor microenvironment (TME). Recently, TME modulation strategies have attracted much attention in cancer immunotherapy. Despite the preliminary success of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9e3a12774af1e45fb188f205ad9bdc
https://doi.org/10.1016/j.bioactmat.2020.12.010
https://doi.org/10.1016/j.bioactmat.2020.12.010
Publikováno v:
Non-coding RNA Research, Vol 6, Iss 1, Pp 51-57 (2021)
Non-coding RNA Research
Non-coding RNA Research
Preeclampsia (PE) is a multi-system disorder that is specific to human pregnancy. Inadequate oxygenation of uterus and placenta is considered as one of the leading causes for the disease. MicroRNA-210(miR-210) is one of the prime molecules that has e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db10a09f759aa2f7b0781f1908ac1b0
http://www.sciencedirect.com/science/article/pii/S2468054021000056
http://www.sciencedirect.com/science/article/pii/S2468054021000056
Autor:
Cristiano Rumio, Fabrizio Marcucci
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 234-245 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 234-245 (2021)
Tumor cells often switch from mitochondrial oxidative metabolism to glycolytic metabolism even under aerobic conditions. Tumor cell glycolysis is accompanied by several nonenzymatic activities among which induction of drug resistance has important th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa5b30ce2ee01dd517b432844e879a6
http://europepmc.org/articles/PMC7804361
http://europepmc.org/articles/PMC7804361