Zobrazeno 1 - 10
of 34
pro vyhledávání: '"HIDETOMO KIKUCHI"'
Autor:
Bo Yuan, Jingmei Li, Shin-Ich Miyashita, Hidetomo Kikuchi, Meiyan Xuan, Hirokazu Matsuzaki, Naohiro Iwata, Shinya Kamiuchi, Katsuyoshi Sunaga, Takeshi Sakamoto, Yasuhide Hibino, Mari Okazaki
Publikováno v:
Molecules, Vol 27, Iss 19, p 6577 (2022)
The cytotoxicity of a trivalent arsenic derivative (arsenite, AsIII) combined with arenobufagin or gamabufotalin was evaluated in human U-87 glioblastoma cells. Synergistic cytotoxicity with upregulated intracellular arsenic levels was observed, when
Externí odkaz:
https://doaj.org/article/4d4495d3f7594f838dd141bd8cc2b1c7
Autor:
Tadasuke Nozaki, Masayuki Takahashi, Tatsuya Ishikawa, Arisa Haino, Mineaki Seki, Hidetomo Kikuchi, Bo Yuan, Masayuki Nashimoto
Publikováno v:
Biochemistry and Biophysics Reports, Vol 26, Iss , Pp 100918- (2021)
TRUE gene silencing is one of the gene suppression technologies. This technology exploits the enzymatic property of the tRNA 3′ processing endoribonuclease tRNase ZL, which is that it can cleave a target RNA under the direction of a small guide RNA
Externí odkaz:
https://doaj.org/article/52194733743746c8848f1c23f6c6fcab
Autor:
Bowen Yu, Bo Yuan, JingZhe Li, Anna Kiyomi, Hidetomo Kikuchi, Hideki Hayashi, Xiaomei Hu, Mari Okazaki, Munetoshi Sugiura, Toshihiko Hirano, Yingyi Fan, Xiaohua Pei, Norio Takagi
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Novel therapeutic strategies for breast cancer are urgently needed due to the sustained development of drug resistance and tumor recurrence. Trivalent arsenic derivative (arsenite, AsIII) has been reported to induce cytotoxicity in breast cancer cell
Externí odkaz:
https://doaj.org/article/8374216646314df88667b782892aa7fd
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 12, Iss 5, Pp 464-469 (2017)
We previously demonstrated that tomato juice (TJ) contains potent mechanism-based inhibitor(s) of CYP3A4. In this study, we investigated the effects of TJ and grapefruit juice (GFJ) on the pharmacokinetics of the CYP3A4-substrate drugs, nifedipine (N
Externí odkaz:
https://doaj.org/article/a4a77f4a695a4cb0981e164aec4e42cf
Autor:
Bo Yuan, Hidetomo Kikuchi, Jingmei Li, Atsushi Kawabata, Kozo Yao, Norio Takagi, Mari Okazaki
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2282
Volume 24
Issue 3
Pages: 2282
To explore the molecular mechanisms of action underlying the antileukemia activities of darinaparsin, an organic arsenical approved for the treatment of peripheral T–cell lymphoma in Japan, cytotoxicity of darinaparsin was evaluated in leukemia cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c662660d2094d7367ee4cb9cac2a492
Autor:
Yuki Toguchi, Hidetomo Kikuchi, Yoshio Nishimura, Bo Yuan, Rie Arai, Hidetsura Cho, Katsuyoshi Sunaga
Dihydropyrimidines (DPs), one of the six-membered heterocyclic compounds, are well known to have a wide range of pharmacological activities including anticancer. Recently, our previous studies have demonstrated that 6-unsubstituted 2-thioxo-, 2-oxo-,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a88efdc75deb27d12ce35bae909d4a79
https://doi.org/10.21203/rs.3.rs-2071332/v1
https://doi.org/10.21203/rs.3.rs-2071332/v1
Autor:
Yoshio Nishimura, Hidetomo Kikuchi, Takanori Kubo, Rie Arai, Yuki Toguchi, Bo Yuan, Katsuyoshi Sunaga, Hidetsura Cho
Publikováno v:
Chemicalpharmaceutical bulletin. 70(2)
An efficient synthetic method for novel 4,4-disubstituted 3,4-dihydropyrimidin-2(1H)-ones 5 and -thiones 6 was developed. The cyclocondensation reaction of O-methylisourea hemisulfate salt 11 with 8 gives a tautomeric mixture of dihydropyrimidines 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b664db155444d71787c593ecf74d55e
https://pubmed.ncbi.nlm.nih.gov/35228390
https://pubmed.ncbi.nlm.nih.gov/35228390
Publikováno v:
American Journal of Cancer Research. 9(8):1517-1535
Cancer is a diverse class of diseases characterized by uncontrolled cell growth with the potential to invade and spread to other parts of the body, and continues to be one of the leading causes of death worldwide. Conventional cancer treatment modali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e49cb94cdc88a897a1bcc97c90c7416e
http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-21566976_9_1517
http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-21566976_9_1517
Autor:
Hideki Hayashi, Anna Kiyomi, Xiaomei Hu, Yingyi Fan, Munetoshi Sugiura, Bowen Yu, JingZhe Li, Xiaohua Pei, Mari Okazaki, Hidetomo Kikuchi, Norio Takagi, Toshihiko Hirano, Bo Yuan
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology
Frontiers in Pharmacology
Novel therapeutic strategies for breast cancer are urgently needed due to the sustained development of drug resistance and tumor recurrence. Trivalent arsenic derivative (arsenite, AsIII) has been reported to induce cytotoxicity in breast cancer cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d34d4bccc513e0050f9b7aede225c0f
https://www.frontiersin.org/article/10.3389/fphar.2020.01087/full
https://www.frontiersin.org/article/10.3389/fphar.2020.01087/full
Autor:
Jingmei Li, Bo Yuan, Meiyan Xuan, Hidetomo Kikuchi, Katsuyoshi Sunaga, Shinya Kamiuchi, Yasuhide Hibino, Hirokazu Matsuzaki, Mari Okazaki
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 95:3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c415c243ceb59927ca6f04d0f9c2eb9
https://doi.org/10.1254/jpssuppl.95.0_3-p-276
https://doi.org/10.1254/jpssuppl.95.0_3-p-276