Zobrazeno 1 - 10
of 32
pro vyhledávání: '"HIDEFUMI WAKASHIN"'
Autor:
Shota Saito, Hirofumi Hashimoto, Hidefumi Wakashin, Misaki Ishibane, Sangjon Pae, Shinpei Saito, Yoshie Reien, Yuri Hirayama, Yoshiteru Seo, Takashi Mizushima, Naohiko Anzai
Publikováno v:
Brain Research Bulletin, Vol 204, Iss , Pp 110788- (2023)
Xenin is a 25-amino acid peptide identified in human gastric mucosa, which is widely expressed in peripheral and central tissues. It is known that the central or peripheral administration of xenin decreases food intake in rodents. Nesfatin-1/NUCB2 (n
Externí odkaz:
https://doaj.org/article/27dbd04463ff4391b949bbb3810c6bce
Autor:
Kentaro Okunushi, Tomomi Furihata, Hanae Morio, Yasuhide Muto, Kosuke Higuchi, Meika Kaneko, Yusuke Otsuka, Yuta Ohno, Yasuhiro Watanabe, Yoshie Reien, Kiyoshi Nakagawa, Shinichi Sakamoto, Hidefumi Wakashin, Naoki Shimojo, Naohiko Anzai
Publikováno v:
Journal of Pharmacological Sciences, Vol 144, Iss 1, Pp 16-22 (2020)
JPH203 is a novel anti-cancer drug targeting L-type amino acid transporter 1 (LAT1), which plays a primary role in the uptake of essential amino acids in tumor cells. Although a co-incubation inhibitory effect of JPH203 has been shown in a convention
Externí odkaz:
https://doaj.org/article/07125b3d021f40f284dbf0801f6b596c
Autor:
Hidefumi Wakashin, Jurgen Heymann, Hila Roshanravan, Parnaz Daneshpajouhnejad, Avi Rosenberg, Myung Kyun Shin, Maarten Hoek, Jeffrey B. Kopp
Publikováno v:
BMC Nephrology, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Apolipoprotein L1, APOL1, is a trypanosome lytic factor present in human and certain other primates. APOL1 gene variants, present in individuals of recent sub-Saharan African descent, increase risk for glomerular disease and assoc
Externí odkaz:
https://doaj.org/article/8bd7cd77becc4b88bc67a883ac557ea2
Autor:
Shashi Shrivastav, Hewang Lee, Koji Okamoto, Huiyan Lu, Teruhiko Yoshida, Khun Zaw Latt, Hidefumi Wakashin, James L. T. Dalgleish, Erik H. Koritzinsky, Peng Xu, Laureano D. Asico, Joon-Yong Chung, Stephen Hewitt, John J. Gildea, Robin A. Felder, Pedro A. Jose, Avi Z. Rosenberg, Mark A. Knepper, Tomoshige Kino, Jeffrey B. Kopp
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
HIV-associated nephropathy (HIVAN) impairs functions of both glomeruli and tubules. Attention has been previously focused on the HIVAN glomerulopathy. Tubular injury has drawn increased attention because sodium wasting is common in hospitalized HIV/A
Externí odkaz:
https://doaj.org/article/593f5764843b42f0b3ac93ffe4adecfb
Publikováno v:
Biology Open, Vol 10, Iss 6 (2021)
Histological studies and magnetic resonance imaging were employed to analyze the kidney structure and function of the freshwater mussel, Nodularia douglasiae. The Nodularia kidney consists of proximal, intermediate and distal tubules. The epithelia o
Externí odkaz:
https://doaj.org/article/e4a348b1eb204cd1886a11c4c593275a
Autor:
Taro Iwamoto, Shigeru Tanaka, Hiroshi Nakajima, Yoshiro Maezawa, Minoru Takemoto, Masashi Fukuta, Kotaro Suzuki, Shotaro Kojima, Yoko Yabe, Kazumasa Suzuki, Kazuma Iida, Hiroyuki Yamada, Shinichi Makino, Arifumi Iwata, Akira Suto, Daiki Nakagomi, Hidefumi Wakashin, Yuko Maezawa, Katsuhiko Asanuma
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss 1 (2021)
Objective Recently, podocytes have been recognised not only as a physical barrier to prevent urinary protein loss but also as producers of proinflammatory cytokines. However, the roles of podocytes in the pathogenesis of lupus nephritis (LN) remain l
Externí odkaz:
https://doaj.org/article/807885cdae6a488a8bae65899791184b
Autor:
John M Carson, Kayo Okamura, Hidefumi Wakashin, Kim McFann, Evgenia Dobrinskikh, Jeffrey B Kopp, Judith Blaine
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99771 (2014)
Albuminuria is a strong, independent predictor of chronic kidney disease progression. We hypothesize that podocyte processing of albumin via the lysosome may be an important determinant of podocyte injury and loss. A human urine derived podocyte-like
Externí odkaz:
https://doaj.org/article/e0280be795214ab3a8fc6613ee68643d
Autor:
Hidefumi Wakashin, Shunsuke Kobayashi, Naohiko Anzai, Kenzo Oba, Misao Terada, K Satoh, Keitaro Hayashi, Akira Shimizu, Hiroe Kon, Hitoshi Sugihara, Tomoe Fujita, Asuka Morita, Motoshi Ouchi
Publikováno v:
In Vivo
Background/aim We developed an experimental method to reproduce insulin secretion from isolated rat pancreas preparations using an organ bath system. However, secretion of trypsin, another pancreatic enzyme, interferes with insulin production in such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3cd6e46d5a7c2c6ee462ec8dda08d6
https://europepmc.org/articles/PMC8408692/
https://europepmc.org/articles/PMC8408692/
Autor:
Kiyoshi Nakagawa, Yoshie Reien, Yusuke Otsuka, Naohiko Anzai, Tomomi Furihata, Shuichi Tsuruoka, Hidefumi Wakashin, Yuta Ohno, Motoshi Ouchi
Publikováno v:
The Journal of Physiological Sciences. 69:635-642
Sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8) mediates monocarboxylate transport in the proximal tubule of the kidney. We have identified PDZK1 and PDZ domain-containing RING finger 3 (PDZRN3) as potent binding partners of SMCT1, which ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1293ef33f94028b48ee18f8a7d0e381
https://doi.org/10.1007/s12576-019-00681-w
https://doi.org/10.1007/s12576-019-00681-w
Publikováno v:
Magnetic Resonance in Medical Sciences. 18:184-193
PURPOSE In order to detect exercised muscles by the increase in T2, we have defined a Gaussian T2 distribution and reference values (T2r and SDr) in resting state muscles, and a threshold for detecting exercised muscles. METHODS The subjects were hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de45feff3b5fee4dfa253e2ac83dea97
https://doi.org/10.2463/mrms.mp.2018-0059
https://doi.org/10.2463/mrms.mp.2018-0059