Developmental plasticity of human foetal femur-derived cells in pellet culture: self assembly of an osteoid shell around a cartilaginous core

Autor: AT El-Serafi, DI Wilson, HI Roach, ROC Oreffo

Publikováno v: European Cells & Materials, Vol 21, Pp 558-567 (2011)

This study has examined the osteogenic and chondrogenic differentiation of human foetal femur-derived cells in 3-dimensional pellet cultures. After culture for 21-28 days in osteogenic media, the pellets acquired a unique configuration that consisted

Externí odkaz: https://doaj.org/article/badea83b70964494b6b23cd7e23dc284

Changes in immunolocalisation of beta-dystroglycan and specific degradative enzymes in the osteoarthritic synovium

Autor: GD Harper, Sanjay Sharma, Dariusz C. Górecki, Chun Fu Lien, Peter A. Brennan, S Wimsey, HI Roach

Publikováno v: Osteoarthritis and cartilage. 14(11)

Objective: To investigate the immunolocalisation of β-dystroglycan (β-DG) and specific matrix metalloproteinases (MMPs)-3, -9, -13 and a disintegrin like and metalloproteinase thrombospondin type 1 motif 4 (ADAMTS-4) within the joint tissues of pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f65f00e2b484d4ed574abda2420825
https://pubmed.ncbi.nlm.nih.gov/16759884

Synthesis of scaffold-free, three dimensional, osteogenic constructs following culture of skeletal osteoprogenitor cells on glass surfaces.

Autor: Alghfeli L; Research Institute for Medical and Health Sciences, University of Sharjah, United Arab Emirates., Parambath D; Research Institute for Medical and Health Sciences, University of Sharjah, United Arab Emirates., Manzoor S; Research Institute for Medical and Health Sciences, University of Sharjah, United Arab Emirates., Roach HI; Bone and Joint Research Group, Institute of Developmental Sciences, University of Southampton, School of Medicine, UK., Oreffo ROC; Bone and Joint Research Group, Institute of Developmental Sciences, University of Southampton, School of Medicine, UK., El-Serafi AT; Research Institute for Medical and Health Sciences, University of Sharjah, United Arab Emirates.; Medical Biochemistry Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.; Department of Biomedical and Clinical Sciences (BKV), Linköping University, Sweden.

Publikováno v: Bone reports [Bone Rep] 2021 Oct 18; Vol. 15, pp. 101143. Date of Electronic Publication: 2021 Oct 18 (Print Publication: 2021).

Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites.

Autor: Hashimoto K; Research Division, Hospital for Special Surgery and Weill Cornell Medical College, New York, New York 10021; Department of Orthopedics, Tohoku University, Sendai 980-8574, Japan., Otero M; Research Division, Hospital for Special Surgery and Weill Cornell Medical College, New York, New York 10021., Imagawa K; Bone and Joint Research Group, Human Development and Health, University of Southampton, Southampton SO16 6YD, United Kingdom., de Andrés MC; Bone and Joint Research Group, Human Development and Health, University of Southampton, Southampton SO16 6YD, United Kingdom., Coico JM; Research Division, Hospital for Special Surgery and Weill Cornell Medical College, New York, New York 10021., Roach HI; Bone and Joint Research Group, Human Development and Health, University of Southampton, Southampton SO16 6YD, United Kingdom., Oreffo ROC; Bone and Joint Research Group, Human Development and Health, University of Southampton, Southampton SO16 6YD, United Kingdom., Marcu KB; Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Centro di Ricerca Codivilla-Putti, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794-5215., Goldring MB; Research Division, Hospital for Special Surgery and Weill Cornell Medical College, New York, New York 10021. Electronic address: goldringm@hss.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2013 Apr 05; Vol. 288 (14), pp. 10061-10072. Date of Electronic Publication: 2013 Feb 15.

Epigenetic regulation during fetal femur development: DNA methylation matters.

Autor: de Andrés MC; Bone and Joint Research Group, University of Southampton, Southampton, United Kingdom., Kingham E, Imagawa K, Gonzalez A, Roach HI, Wilson DI, Oreffo RO

Publikováno v: PloS one [PLoS One] 2013; Vol. 8 (1), pp. e54957. Date of Electronic Publication: 2013 Jan 28.