Zobrazeno 1 - 10
of 34
pro vyhledávání: '"HG Ahuja"'
Publikováno v:
Blood. 78:3259-3268
The retinoblastoma-susceptibility (Rb) gene is an antioncogene that is frequently altered in retinoblastomas, sarcomas, and some epithelial tumors. We examined the structure of the Rb gene by Southern blotting in 215 cases of leukemias and lymphomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f22818ffc3c4c67f6bad01fc0a36f8
https://doi.org/10.1182/blood.v78.12.3259.3259
https://doi.org/10.1182/blood.v78.12.3259.3259
Autor:
A Foti, S. L. Allen, P. Schulman, M. W. Schuster, M. Bar-Eli, HG Ahuja, Martin J. Cline, Prasad Koduru
Publikováno v:
Scopus-Elsevier
A patient with typical Philadelphia chromosome (Ph1)-positive chronic myelocytic leukemia (CML) was studied during sequential phases of disease: (1) initial chronic phase; (2) myeloid blast crisis; (3) second chronic phase; and (4) accelerated diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e61f9ae9c30d0cb1923686bfdab0f6b
https://doi.org/10.1182/blood.v77.11.2441.bloodjournal77112441
https://doi.org/10.1182/blood.v77.11.2441.bloodjournal77112441
Autor:
Martin J. Cline, HG Ahuja
Publikováno v:
Leukemia & Lymphoma. 4:153-158
(1991). Oncogenes and Anti-oncogenes in the Evolution of Human Leukemia/Lymphoma. Leukemia & Lymphoma: Vol. 4, No. 3, pp. 153-158.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abda16d69eddebdc59516e355ff3887d
https://doi.org/10.3109/10428199109068060
https://doi.org/10.3109/10428199109068060
Publikováno v:
Blood. 75:1684-1690
DNA from 161 patients with various forms of hematologic malignancies were investigated for mutations in exons 1 and 2 of the N-RAS, K-RAS and Ha-RAS gene by direct sequencing of DNA amplified in vitro by the polymerase chain reaction. Mutations invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3604307cf676254f02f75f7b4e554171
https://doi.org/10.1182/blood.v75.8.1684.1684
https://doi.org/10.1182/blood.v75.8.1684.1684
Publikováno v:
Blood. 75:819-822
At least 13 of 34 patients with acute myeloid leukemia (AML) of varying FAB types were heterozygous for a BamHI restriction fragment length polymorphism (RFLP) of the Ha-ras gene on chromosome 11. In 4 of these 13 patients, one allele of the Ha-ras g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c9bf481ebd953af1885297140fe9646
https://doi.org/10.1182/blood.v75.4.819.bloodjournal754819
https://doi.org/10.1182/blood.v75.4.819.bloodjournal754819
Publikováno v:
British Journal of Haematology. 76:143-145
Alterations of the p53 anti-oncogene have recently been found to occur frequently in the blast crisis of chronic myelocytic leukaemia. The p53 gene may be altered by gross structural alterations or by point mutations in the coding sequence. We now re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf56280dad8e24511c0213221d3cec07
https://doi.org/10.1111/j.1365-2141.1990.tb07849.x
https://doi.org/10.1111/j.1365-2141.1990.tb07849.x
Publikováno v:
Blood. 75(4)
At least 13 of 34 patients with acute myeloid leukemia (AML) of varying FAB types were heterozygous for a BamHI restriction fragment length polymorphism (RFLP) of the Ha-ras gene on chromosome 11. In 4 of these 13 patients, one allele of the Ha-ras g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147876dded095c8a8aaf434f51cfe306
https://pubmed.ncbi.nlm.nih.gov/1967953
https://pubmed.ncbi.nlm.nih.gov/1967953
Publikováno v:
British Journal of Haematology. 72:36-39
Summary. A novel mutation of the N-RAS gene of T-ALL blast cells was detected by a direct sequencing of in vitro amplified exon-1 of the N-RAS gene. Threonine (ACA) was substituted for alanine (GCA) at codon 11. This mutation would have been overlook
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318e945eeb08feb2e90195979800ead8
https://doi.org/10.1111/j.1365-2141.1989.tb07648.x
https://doi.org/10.1111/j.1365-2141.1989.tb07648.x
Publikováno v:
Proceedings of the National Academy of Sciences. 86:6783-6787
Molecular mechanisms responsible for the clinical progression of chronic myelocytic leukemia to its accelerated phase or to blast crisis have not been defined. We found alterations of the p53 gene (p53 is a 53-kDa nuclear protein) including deletions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a57437996f744c00291c44ecf1a3fee
https://doi.org/10.1073/pnas.86.17.6783
https://doi.org/10.1073/pnas.86.17.6783
Publikováno v:
Blood. 73:281-283
Mutations in codons 12 or 13 of the first exon of the N-RAS gene have been reported in myelodysplastic syndromes (MDS) in frequencies that vary between 9% and 40% depending on the techniques used in analysis. Gene amplification and direct sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23750a8cdadc9cd4f5121a6a729c50df
https://doi.org/10.1182/blood.v73.1.281.bloodjournal731281
https://doi.org/10.1182/blood.v73.1.281.bloodjournal731281