The protozoan parasite Toxoplasma gondii encodes a gamut of phosphodiesterases during its lytic cycle in human cells

Autor: Özlem Günay-Esiyok, Nicolas Liem, Kim Chi Vo, Nishith Gupta

Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 3861-3876 (2020)

Graphical abstract
Highlights • Toxoplasma genome harbors at least 18 phosphodiesterases encoded by distinct genes. • Most parasite PDEs lack regulatory modules and are quite divergent from their human orthologs. • Acutely-infectious tachy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952729672d93971172ad6bb332f7a8ef
http://europepmc.org/articles/PMC7720076

A fluorescent reporter system enables spatiotemporal analysis of host cell modification during herpes simplex virus-1 replication

Autor: Timothy K. Soh, Luca Mascheroni, Vivienne Connor, Katharina M. Scherer, James D. Manton, Clemens F. Kaminski, Colin M. Crump

Publikováno v: The Journal of Biological Chemistry

Herpesviruses are large and complex viruses that have a long history of coevolution with their host species. One important factor in the virus–host interaction is the alteration of intracellular morphology during viral replication with critical imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cec3952cdc85557f3c8aa73279a507
http://europepmc.org/articles/PMC7948757

The nucleocytosolic O-fucosyltransferase SPINDLY affects protein expression and virulence in Toxoplasma gondii

Autor: Giulia Bandini, Christopher M. West, Hanke van der Wel, John Samuelson, Carolina Agop-Nersesian, Hyun W. Kim, Msano Mandalasi

Publikováno v: The Journal of Biological Chemistry

Once considered unusual, nucleocytoplasmic glycosylation is now recognized as a conserved feature of eukaryotes. While in animals, O-GlcNAc transferase (OGT) modifies thousands of intracellular proteins, the human pathogen Toxoplasma gondii transfers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47e5dc6ed26363cc16577e4b3babc28
https://doi.org/10.1074/jbc.ra120.015883

Apically-located P4-ATPase1-Lem1 complex internalizes phosphatidylserine and regulates motility-dependent invasion and egress in Toxoplasma gondii .

Autor: Chen K; Department of Molecular Parasitology, Faculty of Life Sciences, Humboldt University, Berlin, Germany., Huang X; Department of Molecular Parasitology, Faculty of Life Sciences, Humboldt University, Berlin, Germany., Distler U; Institute of Immunology, University Medical Center of the Johannes-Gutenberg University, Mainz, Germany., Tenzer S; Institute of Immunology, University Medical Center of the Johannes-Gutenberg University, Mainz, Germany., Günay-Esiyok Ö; Department of Molecular Parasitology, Faculty of Life Sciences, Humboldt University, Berlin, Germany., Gupta N; Department of Molecular Parasitology, Faculty of Life Sciences, Humboldt University, Berlin, Germany.; Intracellular Parasite Education and Research Labs (iPEARL), Department of Biological Sciences, Birla Institute of Technology and Science, Pilani (BITS-P), Hyderabad, India.

Publikováno v: Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2023 Feb 18; Vol. 21, pp. 1893-1906. Date of Electronic Publication: 2023 Feb 18 (Print Publication: 2023).

Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1 Deficiency.

Autor: Cai K; NHC Key Laboratory of Neonatal Diseases, Cardiovascular Center, Children's Hospital of Fudan University, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Fudan University, Shanghai, China., Wang F; NHC Key Laboratory of Neonatal Diseases, Cardiovascular Center, Children's Hospital of Fudan University, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Fudan University, Shanghai, China., Lu JQ; NHC Key Laboratory of Neonatal Diseases, Cardiovascular Center, Children's Hospital of Fudan University, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Fudan University, Shanghai, China., Shen AN; NHC Key Laboratory of Neonatal Diseases, Cardiovascular Center, Children's Hospital of Fudan University, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Fudan University, Shanghai, China., Zhao SM; NHC Key Laboratory of Neonatal Diseases, Cardiovascular Center, Children's Hospital of Fudan University, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Fudan University, Shanghai, China.; Key Laboratory of Reproduction Regulation of NPFPC, Fudan University, Shanghai, China., Zang WD; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China., Gui YH; NHC Key Laboratory of Neonatal Diseases, Cardiovascular Center, Children's Hospital of Fudan University, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Fudan University, Shanghai, China., Zhao JY; NHC Key Laboratory of Neonatal Diseases, Cardiovascular Center, Children's Hospital of Fudan University, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Fudan University, Shanghai, China.; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.

Publikováno v: JACC. Basic to translational science [JACC Basic Transl Sci] 2022 Apr 25; Vol. 7 (4), pp. 348-362. Date of Electronic Publication: 2022 Apr 25 (Print Publication: 2022).