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Akademický článek

Aggregation as well as chemical modification of LDL during oxidation is responsible for poor processing in macrophages.

Autor: HF Hoff, N Zyromski, D Armstrong, J O'Neil

Publikováno v: Journal of Lipid Research, Vol 34, Iss 11, Pp 1919-1929 (1993)

Aggregation is a characteristic of extensively oxidized (ox-) LDL. We wished to determine whether this structural change contributed even more to the documented poor degradation in macrophages of ox-LDL than the chemical changes. When protein degrada

Externí odkaz: https://doaj.org/article/329697ffd267494d9a6f1ab87dae00cc

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Akademický článek

Structural and functional changes in LDL after modification with both 4-hydroxynonenal and malondialdehyde

Autor: HF Hoff, J O'Neil

Publikováno v: Journal of Lipid Research, Vol 34, Iss 7, Pp 1209-1218 (1993)

Oxidized LDL is characterized by adduct formation between apolipoprotein (apo)B-100 in the low density lipoprotein (LDL) particles and reactive aldehydes such as 4-hydroxynonenal (HNE) and malondialdehyde (MDA), which are decomposition products of li

Externí odkaz: https://doaj.org/article/f6ace865e0fd4734832b12d0a95facb5

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Akademický článek

Partial characterization of lipoproteins containing apo[a] in human atherosclerotic lesions

Autor: HF Hoff, J O'Neil, A Yashiro

Publikováno v: Journal of Lipid Research, Vol 34, Iss 5, Pp 789-798 (1993)

Previously we quantified the amounts of immunoreactive apo[a] found in human atherosclerotic lesions extracted sequentially with phosphate-buffered saline (PBS) and guanidine hydrochloride (GuHCl). In this study we have attempted to characterize lipo

Externí odkaz: https://doaj.org/article/90d1423caee5447e8c3a08f93d23c5ae

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Akademický článek

Quantification of apo[a] and apoB in human atherosclerotic lesions.

Autor: JM Pepin, JA O'Neil, HF Hoff

Publikováno v: Journal of Lipid Research, Vol 32, Iss 2, Pp 317-327 (1991)

Lipoprotein[a] or Lp[a] is a cholesterol-rich plasma lipoprotein that is associated with increased risk for cardiovascular disease. To better understand this association we determined the amount of apo[a] and apoB as possible estimates for Lp[a] and

Externí odkaz: https://doaj.org/article/00aef362f5ac4825b080174036accc17

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Akademický článek

Modified low density lipoprotein isolated from atherosclerotic lesions does not cause lipid accumulation in aortic smooth muscle cells.

Autor: HF Hoff, JM Pepin, RE Morton

Publikováno v: Journal of Lipid Research, Vol 32, Iss 1, Pp 115-124 (1991)

Foam cells in atherosclerotic lesions are derived not only from blood monocytes but also from smooth muscle cells (SMC). To better understand the mechanisms by which SMC may become lipid-laden, we have studied the catabolism by cultured rabbit aortic

Externí odkaz: https://doaj.org/article/030007eb01e442e485a2cae3eee3d53c

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