Zobrazeno 1 - 10
of 1 193
pro vyhledávání: '"HESC"'
Autor:
Daniil Kabanov, Simon Vrana Klimovic, Deborah Beckerová, Martin Molcan, Martin Scurek, Kristian Brat, Marketa Bebarova, Vladimir Rotrekl, Jan Pribyl, Martin Pesl
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The combination of aminophylline and salbutamol is frequently used in clinical practice in the treatment of obstructive lung diseases. While the side effects (including arrhythmias) of the individual bronchodilator drugs were well described
Externí odkaz:
https://doaj.org/article/ef21529e8bbe47919e86f629a259af35
Autor:
Alejandro J Brenes, Eva Griesser, Linda V Sinclair, Lindsay Davidson, Alan R Prescott, Francois Singh, Elizabeth KJ Hogg, Carmen Espejo-Serrano, Hao Jiang, Harunori Yoshikawa, Melpomeni Platani, Jason R Swedlow, Greg M Findlay, Doreen A Cantrell, Angus I Lamond
Publikováno v:
eLife, Vol 13 (2024)
Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and disease modelling. In this study, we characterise the proteomes of multiple hiPSC and hESC line
Externí odkaz:
https://doaj.org/article/a4ed042a121f45aca7b7b1fad3c2840c
Autor:
Shuang Zhao, Jie Li, Songqi Duan, Chang Liu, Hua Wang, Jiangtao Lu, Nannan Zhao, Xiaoyan Sheng, Yiwei wu, Yanjun Li, Baofa Sun, Lin Liu
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background Telomeres consist of repetitive DNA sequences at the chromosome ends to protect chromosomal stability, and primarily maintained by telomerase or occasionally by alternative telomere lengthening of telomeres (ALT) through recombina
Externí odkaz:
https://doaj.org/article/3420e738ce6c4ec28a26af31cf2620db
Autor:
Eun-Young Shin, Suji Jeong, Jeoung Eun Lee, Dong Seok Jeong, Dong Keun Han, Seok-Ho Hong, Dong Ryul Lee
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Objectives Currently, no approved stem cell-based therapies for preserving ovarian function during aging. To solve this problem, we developed a long-term treatment for human embryonic stem cell-derived mesenchymal progenitor cells (hESC-MPCs
Externí odkaz:
https://doaj.org/article/5d9de890cdc7471d9a21026a76c86cee
Autor:
Shiqian Li, Yafei Wang, Miesje van der Stoel, Xin Zhou, Shrinidhi Madhusudan, Kristiina Kanerva, Van Dien Nguyen, Nazli Eskici, Vesa M. Olkkonen, You Zhou, Taneli Raivio, Elina Ikonen
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-26 (2024)
Abstract Recent developments in auxin-inducible degron (AID) technology have increased its popularity for chemogenetic control of proteolysis. However, generation of human AID cell lines is challenging, especially in human embryonic stem cells (hESCs
Externí odkaz:
https://doaj.org/article/b386292dc07c45e88b124344bcaa5ff8
Autor:
Mi-Sun Choi, Se-Myo Park, Soojin Kim, Hyun Jegal, Hyang-Ae Lee, Hyoung-Yun Han, Seokjoo Yoon, Sang-Kyum Kim, Jung-Hwa Oh
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 280, Iss , Pp 116516- (2024)
The assessment of neurotoxicity for environmental chemicals is of utmost importance in ensuring public health and environmental safety. Multielectrode array (MEA) technology has emerged as a powerful tool for assessing disturbances in the electrophys
Externí odkaz:
https://doaj.org/article/1109831dd2084c1d9ddee85aeb091bf0
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Background Human pluripotent stem cell (hPSC)-derived hepatocyte-like cells (HLCs) can provide a valuable in vitro model for disease modelling and drug development. However, generating HLCs with characteristics comparable to hepatocytes in v
Externí odkaz:
https://doaj.org/article/49634cbe55714741bb334873f0bdec14
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Autor:
Hai-Tao Luo, Qian He, Wei Yang, Fei He, Jun Dong, Chao-Feng Hu, Xiao-Fei Yang, Ning Li, Fu-Rong Li
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Background Deep understanding the differentiation process of human embryonic stem cells (hESCs) is essential for developing cell-based therapeutic strategy. Substantial efforts have been made to investigate protein-coding genes, yet it remai
Externí odkaz:
https://doaj.org/article/8812b17dd5e14d4d95b8ca4b66a6390c
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 686-702 (2022)
It has recently been shown that CFIm25, a canonical mRNA 3’ processing factor, could play a variety of physiological roles through its molecular function in the regulation of mRNA alternative polyadenylation (APA). Here, we used CRISPR/Cas9-mediate
Externí odkaz:
https://doaj.org/article/91ac532172af45b59b4488ef05e09b6b