Zobrazeno 1 - 10
of 6 956
pro vyhledávání: '"HERDEWIJN, P."'
Autor:
Jean Herman, Els Vanstreels, Dorothée Bardiot, Andrea E Prota, Natacha Gaillard, Ling-Jie Gao, Thomas Vercruysse, Leentje Persoons, Tinne Daems, Mark Waer, Piet Herdewijn, Thierry Louat, Michel O Steinmetz, Steven De Jonghe, Ben Sprangers, Dirk Daelemans
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0307153 (2024)
Microtubule-targeting agents are an important class of anti-cancer drugs; their full potential is however not realized because of significant myelotoxicity and neurotoxicity. We here report 3-nitropyridine analogues as a novel group of microtubule-ta
Externí odkaz:
https://doaj.org/article/6fdecf164cea42cdbd9b349cb2345daf
Autor:
Li X; Department of Pharmaceutical Sciences, Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Herestraat 49, Box 1030, Leuven, B-3000, Belgium., Groaz E; Department of Pharmaceutical Sciences, Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Herestraat 49, Box 1030, Leuven, B-3000, Belgium., Herdewijn P; Department of Pharmaceutical Sciences, Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Herestraat 49, Box 1030, Leuven, B-3000, Belgium., Lescrinier E; Department of Pharmaceutical Sciences, Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Herestraat 49, Box 1030, Leuven, B-3000, Belgium.
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Jul 02; Vol. 30 (37), pp. e202401254. Date of Electronic Publication: 2024 May 28.
Akademický článek
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Akademický článek
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Autor:
Abhimanyu K. Singh, Sergio E. Martinez, Weijie Gu, Hoai Nguyen, Dominique Schols, Piet Herdewijn, Steven De Jonghe, Kalyan Das
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Here the authors observe a transient P-pocket created when HIV reverse transcriptase slides over DNA substrate, identify fragments targeting this pocket, and develop a cryo-EM platform for lead optimization.
Externí odkaz:
https://doaj.org/article/9dfb249ea4bc4f7bbae81ab4c18df594
Autor:
Leah V. Goulding, Eleonóra Kiss, Robert Vrancken, Nesya Goris, Min Luo, Elisabetta Groaz, Piet Herdewijn, Linda Dixon
Publikováno v:
mSphere, Vol 7, Iss 6 (2022)
ABSTRACT African swine fever virus (ASFV) causes a highly contagious hemorrhagic disease with case fatality rates approaching 100% in domestic pigs. ASFV is responsible for substantial economic losses, but despite ongoing efforts, no vaccine or antiv
Externí odkaz:
https://doaj.org/article/1962acad012b40d8bbf2d06ab8f2d924
Autor:
De S; InnoSyn B.V., Urmonderbaan 22, 6167 RD Geleen, The Netherlands., De Jonghe S; KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49, 3000 Leuven, Belgium., Herdewijn P; KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49, 3000 Leuven, Belgium.
Publikováno v:
The Journal of organic chemistry [J Org Chem] 2024 Nov 12. Date of Electronic Publication: 2024 Nov 12.
Autor:
Zhang Z; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, 450001, China., Wang N; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Pingyuan Laboratory, State Key Laboratory of Antiviral Drugs, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou, 450001, China., Lu J; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, 450001, China., Qu Y; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, 450001, China., Song Y; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China., Yang X; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China., Wei Z; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengdong New District Longzi Lake 15#, Zhengzhou 450046, China., Zhang Q; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China., Herdewijn P; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; XNA Platform, Institute of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China., Chang J; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, 450001, China. Electronic address: changjunbiao@zzu.edu.cn., Wang XN; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Pingyuan Laboratory, State Key Laboratory of Antiviral Drugs, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou, 450001, China. Electronic address: wangxn@zzu.edu.cn., Wang Z; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, 450001, China; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengdong New District Longzi Lake 15#, Zhengzhou 450046, China; XNA Platform, Institute of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China. Electronic address: zhenyawang@zzu.edu.cn.
Publikováno v:
European journal of medicinal chemistry [Eur J Med Chem] 2024 Nov 08; Vol. 281, pp. 117044. Date of Electronic Publication: 2024 Nov 08.
Autor:
Herman J; 4AZA Biosciences, Leuven, Belgium.; Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium.; Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.; Department of Pediatric Nephrology and Solid Organ Transplantation, University Hospitals Leuven, Leuven, Belgium., Vanstreels E; Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium., Bardiot D; 4AZA Biosciences, Leuven, Belgium., Prota AE; Laboratory of Biomolecular Research, Center for Life Sciences, Paul Scherrer Institut, Würenlingen, Switzerland., Gaillard N; Laboratory of Biomolecular Research, Center for Life Sciences, Paul Scherrer Institut, Würenlingen, Switzerland., Gao LJ; 4AZA Biosciences, Leuven, Belgium.; Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium.; Laboratory of Medicinal Chemistry, Department of Pharmaceutical and Pharmacological Sciences, Rega Institute, KU Leuven, Leuven, Belgium., Vercruysse T; Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium., Persoons L; Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium., Daems T; 4AZA Biosciences, Leuven, Belgium., Waer M; 4AZA Biosciences, Leuven, Belgium.; Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium.; Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium., Herdewijn P; 4AZA Biosciences, Leuven, Belgium.; Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium.; Laboratory of Medicinal Chemistry, Department of Pharmaceutical and Pharmacological Sciences, Rega Institute, KU Leuven, Leuven, Belgium., Louat T; 4AZA Biosciences, Leuven, Belgium.; Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium., Steinmetz MO; Laboratory of Biomolecular Research, Center for Life Sciences, Paul Scherrer Institut, Würenlingen, Switzerland.; University of Basel, Basel, Switzerland., De Jonghe S; 4AZA Biosciences, Leuven, Belgium.; Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium.; Molecular Structural and Translational Virology Research Group, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium., Sprangers B; Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium.; Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.; Department of Nephrology, University Hospitals Leuven, Leuven, Belgium., Daelemans D; Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
Publikováno v:
PloS one [PLoS One] 2024 Nov 07; Vol. 19 (11), pp. e0307153. Date of Electronic Publication: 2024 Nov 07 (Print Publication: 2024).
Akademický článek
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