Výsledky vyhledávání - "HEPATIC TRANSPORT"

N-(4-[18F]fluorobenzyl)cholylglycine, a potential tracer for positron emission tomography of enterohepatic circulation and drug-induced inhibition of ileal bile acid transport:A proof-of-concept PET/CT study in pigs

Autor: Kim Frisch, Frank Viborg Mortensen, Ole Lajord Munk, Lars Christian Gormsen, Aage Kristian Olsen Alstrup

Publikováno v: Frisch, K, Mortensen, F V, Munk, O L, Gormsen, L C & Alstrup, A K O 2022, ' N-(4-[ 18 F]fluorobenzyl)cholylglycine, a potential tracer for positron emission tomography of enterohepatic circulation and drug-induced inhibition of ileal bile acid transport : A proof-of-concept PET/CT study in pigs ', Nuclear Medicine and Biology, vol. 114-115, pp. 49-57 . https://doi.org/10.1016/j.nucmedbio.2022.08.007

Introduction: Enterohepatic circulation (EHC) of conjugated bile acids is an important physiological process crucial for bile acids to function as detergents and signal carriers. Perturbation of the EHC by disease or drugs may lead to serious and lif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014a36005dad467f294ec5efa87cf14e
https://pure.au.dk/portal/da/publications/n418ffluorobenzylcholylglycine-a-potential-tracer-for-positron-emission-tomography-of-enterohepatic-circulation-and-druginduced-inhibition-of-ileal-bile-acid-transport(f0efccaa-4397-4c97-bf95-4b7fc6b4a347).html

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Quantitative Kinetic Models from Intravital Microscopy: A Case Study Using Hepatic Transport

Autor: Richard O. Day, Steve Pressé, Meysam Tavakoli, Kenneth W. Dunn, Konstantinos Tsekouras

Publikováno v: The Journal of Physical Chemistry B. 123:7302-7312

The liver performs critical physiological functions, including metabolizing and removing substances, such as toxins and drugs, from the bloodstream. Hepatotoxicity itself is intimately linked to abnormal hepatic transport and hepatotoxicity remains t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42a09c9295300d9082e658ac2ef3eb4
https://doi.org/10.1021/acs.jpcb.9b04729

Zobrazit plný text záznamu

Akademický článek

Dynamic Determination of Kinetic Parameters for the Interaction between Polypeptide Hormones and Cell-Surface Receptors in the Perfused Rat Liver by the Multiple-Indicator Dilution Method

Autor: Sato, H., Sugiyama, Y., Sawada, Y., Iga, T., Sakamoto, S., Fuwa, T., Hanano, M.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1988 Nov 01. 85(21), 8355-8359.

Externí odkaz: https://www.jstor.org/stable/32631

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Imaging Probes and Modalities for the Study of Solute Carrier O (SLCO)-Transport Function In Vivo

Autor: Xavier Declèves, Solène Marie, Salvatore Cisternino, Nicolas Tournier, Irène Buvat

Publikováno v: Journal of Pharmaceutical Sciences
Journal of Pharmaceutical Sciences, Wiley, 2017, 106 (9), pp.2335-2344. ⟨10.1016/j.xphs.2017.04.031⟩
Journal of Pharmaceutical Sciences, 2017, 106 (9), pp.2335-2344. ⟨10.1016/j.xphs.2017.04.031⟩

International audience; Transporters of the Solute Carrier O (SLCO) family, former organic anion-transportingpolypeptides (OATP), are now recognized as key players in pharmacokinetics. Imagingis increasingly regarded as a relevant method to elucidate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b940001cfe17d8a3ef380586fc707b
https://doi.org/10.1016/j.xphs.2017.04.031

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Hepatic Clearance Prediction of Nine Human Immunodeficiency Virus Protease Inhibitors in Rat

Autor: Tom De Bruyn, Pieter Annaert, Patrick Augustijns

Publikováno v: Journal of Pharmaceutical Sciences. 105:846-853

This study aimed to determine the rate-limiting step in the overall hepatic clearance of the marketed human immunodeficiency virus (HIV) protease inhibitors (PI) in rats by predicting the experimentally determined hepatic in vivo clearance of these d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e5af361cdf76169217802b4249cc82
https://doi.org/10.1002/jps.24559

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání