Zobrazeno 1 - 10
of 227
pro vyhledávání: '"HEK293T cells"'
Cutting-Edge HEK293T Protein-Integrated Lipid Nanostructures: Boosting Biocompatibility and Efficacy
Autor:
Jung-Hyun Park, Cheng-Zhe Bai, Jeong-Hun Kwak, Ho-Joong Choi, Dosang Lee, Ha-Eun Hong, Ok-Hee Kim, Say-June Kim
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3294 (2024)
Recently, artificial exosomes have been developed to overcome the challenges of natural exosomes, such as production scalability and stability. In the production of artificial exosomes, the incorporation of membrane proteins into lipid nanostructures
Externí odkaz:
https://doaj.org/article/ce0f4f7f003e43f6a7d63b163d934b17
Publikováno v:
Molecular Therapy: Oncolytics, Vol 23, Iss , Pp 582-592 (2021)
Lentiviral vectors (LVs) are robust delivery vehicles for gene therapy as they can efficiently integrate transgenes into host cell genomes. However, LVs with lengthy or complex expression cassettes typically are produced at low titers and have reduce
Externí odkaz:
https://doaj.org/article/8d9f5440d6cd42d0a5f0940f9f1a0fa1
Autor:
Elizaveta A. Zolotenkova, Alexander V. Gopanenko, Alexey E. Tupikin, Marsel R. Kabilov, Alexey A. Malygin
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6173 (2023)
Ribosomal protein uL15 (RPL27a) carries a specific modification, hydroxylation, at the His39 residue, which neighbors the CCA terminus of the E-site-bound tRNA at the mammalian ribosome. Under hypoxia, the level of hydroxylation of this protein decre
Externí odkaz:
https://doaj.org/article/b1f97c58377f4d21b7c4ae1c53d3e0ba
Autor:
Dahae Hailey Bae, Michael Marino, Brian Iaffaldano, Sydney Fenstermaker, Sandra Afione, Takele Argaw, Jacob McCright, Anna Kwilas, John A. Chiorini, Andrew E. Timmons, Jakob Reiser
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 631-638 (2020)
The use of the human embryonic kidney (HEK) 293T cell line to manufacture vectors for in vivo applications raises safety concerns due to the presence of SV40 T antigen-encoding sequences. We used CRISPR-Cas9 genome editing to remove the SV40 T antige
Externí odkaz:
https://doaj.org/article/8da80acc707540e8a11da1b98006448b
Publikováno v:
Materials & Design, Vol 213, Iss , Pp 110362- (2022)
Hydrogels comprised of alginate and gelatin are potential biomaterials for extrusion-based bioprinting. However, existing polymeric inks are inadequate in printability, shape fidelity and mechanical properties that desire to produce scaffold using 3D
Externí odkaz:
https://doaj.org/article/c299326fc54c417195802223b4e662b2
Publikováno v:
Bioengineering, Vol 9, Iss 11, p 713 (2022)
Virus-like particles (VLPs) are nanoplatforms comprised of one or more viral proteins with the capacity to self-assemble without viral genetic material. VLPs arise as promising nanoparticles (NPs) that can be exploited as vaccines, as drug delivery v
Externí odkaz:
https://doaj.org/article/bd04a3decc054cd88d3144b2ad24b898
Akademický článek
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Akademický článek
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Autor:
Olga A. Kossinova, Alexander V. Gopanenko, Elena S. Babaylova, Alexey E. Tupikin, Marsel R. Kabilov, Alexey A. Malygin, Galina G. Karpova
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9740 (2022)
The RNA cytosine C5 methyltransferase NSUN2 has a variety of RNA substrates and plays an important role in mRNA metabolism. NSUN2 binds to specific sequences enriched in exosomal mRNAs, suggesting its possible involvement in the sorting of mRNAs into
Externí odkaz:
https://doaj.org/article/8a73f0d5d4e84d8587f22adb68813492
Publikováno v:
PeerJ, Vol 9, p e11816 (2021)
Background Polychlorinated biphenyls (PCBs) are persistent pollutants with carcinogenesis and mutagenesis effects which have been closely associated with PCBs-induced DNA damage. However, the detailed DNA damage events and corresponding pathway alter
Externí odkaz:
https://doaj.org/article/ad06873af5e64a2389d5a59061944219