Zobrazeno 1 - 10
of 306
pro vyhledávání: '"HEIKE I. GRABSCH"'
Autor:
Kelly Offermans, Nic G. Reitsam, Colinda C. J. M. Simons, Bianca Grosser, Jessica Zimmermann, Heike I. Grabsch, Bruno Märkl, Piet A. van den Brandt
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-14 (2024)
Abstract Background Stroma AReactive Invasion Front Areas (SARIFA) is a recently identified haematoxylin & eosin (H&E)based histopathologic biomarker in gastrointestinal cancers, including colorectal cancer (CRC), defined as direct contact between tu
Externí odkaz:
https://doaj.org/article/ef24485a2135485c9e416501243ac481
Publikováno v:
Journal of Pathology Informatics, Vol 15, Iss , Pp 100367- (2024)
Background: Histological examination of tumor draining lymph nodes (LNs) plays a vital role in cancer staging and prognostication. However, as soon as a LN is classed as metastasis-free, no further investigation will be performed and thus, potentiall
Externí odkaz:
https://doaj.org/article/aff0db9105ec4bdf962ff5308eec5c28
Autor:
Alexander J. Pennings, MSc, Brecht A. van der Velden, BSc, Maximilian Kloft, MSc, Loes F. S. Kooreman, MSc, Jos M. P. Kleijnen, PhD, Stephanie O. Breukink, PhD, Geerard L. Beets, PhD, Heike I. Grabsch, PhD, Jarno Melenhorst, PhD
Publikováno v:
Annals of Surgery Open, Vol 4, Iss 4, p e336 (2023)
Objective:. In this review, we aim to provide an overview of literature on lymph node (LN) histomorphological features and their relationship with the prognosis in colorectal cancer (CRC). Background:. Lymph nodes play a crucial role in the treatment
Externí odkaz:
https://doaj.org/article/13b2c04384a84f0a8d786c601841088f
Autor:
Loes F. S. Kooreman, Sabine Dieleman, Sander M. J. van Kuijk, Axel zur Hausen, Marjolein L. Smidt, Heike I. Grabsch
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSentinel lymph node (SLN) metastasis is an important predictor of prognosis in breast cancer (BC) patients, guiding treatment decisions. However, patients with the same BC subtype and tumor negative SLN (SLNneg) can have different surviva
Externí odkaz:
https://doaj.org/article/ba5e5f927f954cdfa671a00360e1ec9f
Autor:
Kelly Offermans, Josien C. A. Jenniskens, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Jaleesa R. M. van derMeer, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike I. Grabsch, Piet A. van denBrandt
Publikováno v:
Cancer Medicine, Vol 12, Iss 2, Pp 1137-1156 (2023)
Abstract Background Previous research suggests that Warburg‐subtypes are related to potentially important survival differences in colorectal cancer (CRC) patients. In the present study, we investigated whether mutational subgroups based on somatic
Externí odkaz:
https://doaj.org/article/4f16f53a66a34d5caf70310b0fd58b56
Autor:
Thirza J.S. Opbroek, Yves C.P. Willems, Frank Verhaegen, Rogier de Ridder, Chantal Hoge, Jarno Melenhorst, Frans Bakers, Heike I. Grabsch, Jeroen Buijsen, Evert J. Van Limbergen, Richard A.M. Canters, Maaike Berbée
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 38, Iss , Pp 90-95 (2023)
Background and purpose: Dose-escalation in rectal cancer (RCa) may result in an increased complete response rate and thereby enable omission of surgery and organ preservation. In order to implement dose-escalation, it is crucial to develop a techniqu
Externí odkaz:
https://doaj.org/article/96b84526eb9c455b864f8910233a06ce
Autor:
Timo Hess, Carlo Maj, Jan Gehlen, Oleg Borisov, Stephan L. Haas, Ines Gockel, Michael Vieth, Guillaume Piessen, Hakan Alakus, Yogesh Vashist, Carina Pereira, Michael Knapp, Vitalia Schüller, Alexander Quaas, Heike I. Grabsch, Jessica Trautmann, Ewa Malecka-Wojciesko, Anna Mokrowiecka, Jan Speller, Andreas Mayr, Julia Schröder, Axel M. Hillmer, Dominik Heider, Florian Lordick, Ángeles Pérez-Aísa, Rafael Campo, Jesús Espinel, Fernando Geijo, Concha Thomson, Luis Bujanda, Federico Sopeña, Ángel Lanas, María Pellisé, Claudia Pauligk, Thorsten Oliver Goetze, Carolin Zelck, Julian Reingruber, Emadeldin Hassanin, Peter Elbe, Sandra Alsabeah, Mats Lindblad, Magnus Nilsson, Nicole Kreuser, René Thieme, Francesca Tavano, Roberta Pastorino, Dario Arzani, Roberto Persiani, Jin-On Jung, Henrik Nienhüser, Katja Ott, Ralf R. Schumann, Oliver Kumpf, Susen Burock, Volker Arndt, Anna Jakubowska, Małgorzta Ławniczak, Victor Moreno, Vicente Martín, Manolis Kogevinas, Marina Pollán, Justyna Dąbrowska, Antonio Salas, Olivier Cussenot, Anne Boland-Auge, Delphine Daian, Jean-Francois Deleuze, Erika Salvi, Maris Teder-Laving, Gianluca Tomasello, Margherita Ratti, Chiara Senti, Valli De Re, Agostino Steffan, Arnulf H. Hölscher, Katharina Messerle, Christiane Josephine Bruns, Armands Sīviņš, Inga Bogdanova, Jurgita Skieceviciene, Justina Arstikyte, Markus Moehler, Hauke Lang, Peter P. Grimminger, Martin Kruschewski, Nikolaos Vassos, Claus Schildberg, Philipp Lingohr, Karsten Ridwelski, Hans Lippert, Nadine Fricker, Peter Krawitz, Per Hoffmann, Markus M. Nöthen, Lothar Veits, Jakob R. Izbicki, Adrianna Mostowska, Federico Martinón-Torres, Daniele Cusi, Rolf Adolfsson, Geraldine Cancel-Tassin, Aksana Höblinger, Ernst Rodermann, Monika Ludwig, Gisela Keller, Andres Metspalu, Hermann Brenner, Joerg Heller, Markus Neef, Michael Schepke, Franz Ludwig Dumoulin, Lutz Hamann, Renato Cannizzaro, Michele Ghidini, Dominik Plaßmann, Michael Geppert, Peter Malfertheiner, Olivier Glehen, Tomasz Skoczylas, Marek Majewski, Jan Lubiński, Orazio Palmieri, Stefania Boccia, Anna Latiano, Nuria Aragones, Thomas Schmidt, Mário Dinis-Ribeiro, Rui Medeiros, Salah-Eddin Al-Batran, Mārcis Leja, Juozas Kupcinskas, María A. García-González, Marino Venerito, Johannes Schumacher
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104709- (2023)
Externí odkaz:
https://doaj.org/article/095484ffbd5043c092541fc7d85f94c6
Autor:
Timo Hess, Carlo Maj, Jan Gehlen, Oleg Borisov, Stephan L. Haas, Ines Gockel, Michael Vieth, Guillaume Piessen, Hakan Alakus, Yogesh Vashist, Carina Pereira, Michael Knapp, Vitalia Schüller, Alexander Quaas, Heike I. Grabsch, Jessica Trautmann, Ewa Malecka-Wojciesko, Anna Mokrowiecka, Jan Speller, Andreas Mayr, Julia Schröder, Axel M. Hillmer, Dominik Heider, Florian Lordick, Ángeles Pérez-Aísa, Rafael Campo, Jesús Espinel, Fernando Geijo, Concha Thomson, Luis Bujanda, Federico Sopeña, Ángel Lanas, María Pellisé, Claudia Pauligk, Thorsten Oliver Goetze, Carolin Zelck, Julian Reingruber, Emadeldin Hassanin, Peter Elbe, Sandra Alsabeah, Mats Lindblad, Magnus Nilsson, Nicole Kreuser, René Thieme, Francesca Tavano, Roberta Pastorino, Dario Arzani, Roberto Persiani, Jin-On Jung, Henrik Nienhüser, Katja Ott, Ralf R. Schumann, Oliver Kumpf, Susen Burock, Volker Arndt, Anna Jakubowska, Małgorzta Ławniczak, Victor Moreno, Vicente Martín, Manolis Kogevinas, Marina Pollán, Justyna Dąbrowska, Antonio Salas, Olivier Cussenot, Anne Boland-Auge, Delphine Daian, Jean-Francois Deleuze, Erika Salvi, Maris Teder-Laving, Gianluca Tomasello, Margherita Ratti, Chiara Senti, Valli De Re, Agostino Steffan, Arnulf H. Hölscher, Katharina Messerle, Christiane Josephine Bruns, Armands Sīviņš, Inga Bogdanova, Jurgita Skieceviciene, Justina Arstikyte, Markus Moehler, Hauke Lang, Peter P. Grimminger, Martin Kruschewski, Nikolaos Vassos, Claus Schildberg, Philipp Lingohr, Karsten Ridwelski, Hans Lippert, Nadine Fricker, Peter Krawitz, Per Hoffmann, Markus M. Nöthen, Lothar Veits, Jakob R. Izbicki, Adrianna Mostowska, Federico Martinón-Torres, Daniele Cusi, Rolf Adolfsson, Geraldine Cancel-Tassin, Aksana Höblinger, Ernst Rodermann, Monika Ludwig, Gisela Keller, Andres Metspalu, Hermann Brenner, Joerg Heller, Markus Neef, Michael Schepke, Franz Ludwig Dumoulin, Lutz Hamann, Renato Cannizzaro, Michele Ghidini, Dominik Plaßmann, Michael Geppert, Peter Malfertheiner, Olivier Gehlen, Tomasz Skoczylas, Marek Majewski, Jan Lubiński, Orazio Palmieri, Stefania Boccia, Anna Latiano, Nuria Aragones, Thomas Schmidt, Mário Dinis-Ribeiro, Rui Medeiros, Salah-Eddin Al-Batran, Mārcis Leja, Juozas Kupcinskas, María A. García-González, Marino Venerito, Johannes Schumacher
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104616- (2023)
Summary: Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim
Externí odkaz:
https://doaj.org/article/bec8e38288e64b4d97506fb3356c481a
Autor:
Takashi Oshima, Akira Tsuburaya, Kazuhiro Yoshida, Takaki Yoshikawa, Yohei Miyagi, Yasushi Rino, Munetaka Masuda, Jia Guan, Patrick Tan, Heike I. Grabsch, Junichi Sakamoto, Shiro Tanaka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Biomarkers for selecting gastric cancer (GC) patients likely to benefit from sequential paclitaxel treatment followed by fluorinated-pyrimidine-based adjuvant chemotherapy (sequential paclitaxel) were investigated using tissue samples of pat
Externí odkaz:
https://doaj.org/article/3490e49ae22448bb9aa9e7ab09f03781
Autor:
Kelly Offermans, Josien CA Jenniskens, Colinda CJM Simons, Iryna Samarska, Gregorio E Fazzi, Kim M Smits, Leo J Schouten, Matty P Weijenberg, Heike I Grabsch, Piet A van denBrandt
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 2, Pp 169-180 (2022)
Abstract Previous research has suggested that the expression of proteins related to the Warburg effect may have prognostic value in colorectal cancer (CRC), but results remain inconsistent. Our objective was to investigate the relationship between Wa
Externí odkaz:
https://doaj.org/article/9c0fc1e9bb1c44d88a6b97e04a5cd4f4