Cisplatin induces differentiation in teratomas derived from pluripotent stem cells

Autor: Masahiko Kuroda, Shin-ichiro Ohno, Atsushi Kurata, Koji Fujita, Masakatsu Takanashi

Publikováno v: Regenerative Therapy, Vol 18, Iss, Pp 117-126 (2021)
Regenerative Therapy

Introduction Currently, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be induced to differentiate at the cellular level but not to form mature tissues or organs suitable for transplantation. ESCs/iPSCs form immature terat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0302a91815aa58e9988fab6419f42486
http://www.sciencedirect.com/science/article/pii/S2352320421000432

Evaluation of Systemic and Mucosal Immune Responses Induced by a Nasal Powder Delivery System in Conjunction with an OVA Antigen in Cynomolgus Monkeys

Autor: Keita Sasaki, Akifumi Kyuno, Shunji Haruta, Yuji Sasaki, Akihide Tanimoto, Yusuke Torikai

Publikováno v: Journal of Pharmaceutical Sciences

An immune response for a nasal ovalbumin (OVA) powder formulation with an applied nasal delivery platform technology, consisting of a powdery nasal carrier and a device, was evaluated in monkeys with similar upper respiratory tracts and immune system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebe856837a1444a730e623a41003518
https://doi.org/10.1016/j.xphs.2020.11.023

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Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis

Autor: Xupeng Bai, Ying Zhu, Shanping Wang, Yong Li, Julia Beretov, Valerie C. Wasinger, Jie Ni, Peter Graham

Publikováno v: Redox Biology, Vol 43, Iss, Pp 101993-(2021)
Redox Biology

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. Radiotherapy is an effective option for the treatment of TNBC; however, acquired radioresistance is a major challenge to the modality. In this study, we show that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8986d1327198e28dff514db33736311
http://www.sciencedirect.com/science/article/pii/S2213231721001518

Whole tissue cervical mapping of HPV infection: Molecular evidence for focal latent HPV infection in humans

Autor: Hans Svanholm, John Doorbar, Torben Steiniche, Wim Gv Quint, Heather Griffin, Anne Hammer, Maurits N. C. de Koning, Patti E. Gravitt, Jan Blaakær, Else Mejlgaard

Publikováno v: Papillomavirus Research, Vol 7, Iss, Pp 82-87 (2019)
Hammer, A, de Koning, M NC, Blaakaer, J, Steiniche, T, Doorbar, J, Griffin, H, Mejlgaard, E, Svanholm, H, Quint, W GV & Gravitt, P E 2019, ' Whole tissue cervical mapping of HPV infection : Molecular evidence for focal latent HPV infection in humans ', Papillomavirus Research, vol. 7, no. June, pp. 82-87 . https://doi.org/10.1016/j.pvr.2019.02.004
Hammer, A, de Koning, M NC, Blaakaer, J, Steiniche, T, Doorbar, J, Griffin, H, Mejlgaard, E, Svanholm, H, Quint, W GV & Gravitt, P E 2019, ' Whole tissue cervical mapping of HPV infection : Molecular evidence for focal latent HPV infection in humans ', Papillomavirus Research, vol. 7, pp. 82-87 . https://doi.org/10.1016/j.pvr.2019.02.004
Hammer, A, de Koning, M, Doorbar, J, Griffin, H, Blaakær, J, Steiniche, T, Mejlgaard, E, Svanholm, H, Quint, W & Gravitt, P 2019, ' Whole tissue cervical mapping of HPV infection: molecular evidence for focal latent HPV infection in human ', Papillomavirus research (Amsterdam, Netherlands) .
Papillomavirus Research

In this study, we aimed to provide molecular evidence of HPV latency in humans and discuss potential challenges of conducting studies on latency. We analyzed the entire cervix of two women who underwent hysterectomy unrelated to cervical abnormality.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c25b1f2bbecd2334a5afb8b3dbdd3a6
http://www.sciencedirect.com/science/article/pii/S2405852118301460