Zobrazeno 1 - 10
of 46
pro vyhledávání: '"HDXMS"'
Autor:
Sean M Braet, Theresa SC Buckley, Varun Venkatakrishnan, Kim-Marie A Dam, Pamela J Bjorkman, Ganesh S Anand
Publikováno v:
eLife, Vol 12 (2023)
SARS-CoV-2 emergent variants are characterized by increased viral fitness and each shows multiple mutations predominantly localized to the spike (S) protein. Here, amide hydrogen/deuterium exchange mass spectrometry has been applied to track changes
Externí odkaz:
https://doaj.org/article/e132c898884c4543b6bf006d6de5b0b7
Autor:
Deepa Balasubramaniam, Oliver Schroeder, Anna M. Russell, Jonathan R. Fitchett, Aaron K. Austin, Thomas P. Beyer, Yan Q. Chen, Jonathan W. Day, Mariam Ehsani, Aik Roy Heng, Eugene Y. Zhen, Julian Davies, Wolfgang Glaesner, Bryan E. Jones, Robert W. Siegel, Yue-Wei Qian, Robert J. Konrad
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 5, Pp 100198- (2022)
Triglycerides (TG) are required for fatty acid transport and storage and are essential for human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a complex with ANGPTL3 that increases circulating TG by potently inhibiti
Externí odkaz:
https://doaj.org/article/26adf6a9de994f0db3750f1688a02589
Autor:
Palur V Raghuvamsi, Nikhil K Tulsian, Firdaus Samsudin, Xinlei Qian, Kiren Purushotorman, Gu Yue, Mary M Kozma, Wong Y Hwa, Julien Lescar, Peter J Bond, Paul A MacAry, Ganesh S Anand
Publikováno v:
eLife, Vol 10 (2021)
The spike (S) protein is the main handle for SARS-CoV-2 to enter host cells via surface angiotensin-converting enzyme 2 (ACE2) receptors. How ACE2 binding activates proteolysis of S protein is unknown. Here, using amide hydrogen–deuterium exchange
Externí odkaz:
https://doaj.org/article/edbdeb7b5ce14846aca9ce972b3d86d3
Autor:
Amanda F Clouser, Hannah ER Baughman, Benjamin Basanta, Miklos Guttman, Abhinav Nath, Rachel E Klevit
Publikováno v:
eLife, Vol 8 (2019)
Small heat shock proteins (sHSPs) are nature’s ‘first responders’ to cellular stress, interacting with affected proteins to prevent their aggregation. Little is known about sHSP structure beyond its structured α-crystallin domain (ACD), which
Externí odkaz:
https://doaj.org/article/42145fa1b59a4e9da224de0d823a04d8
Autor:
Catherine A. Sabatos-Peyton, James Nevin, Ansgar Brock, John D. Venable, Dewar J. Tan, Nasim Kassam, Fangmin Xu, John Taraszka, Luke Wesemann, Thomas Pertel, Nandini Acharya, Max Klapholz, Yassaman Etminan, Xiaomo Jiang, Yu-Hwa Huang, Richard S. Blumberg, Vijay K. Kuchroo, Ana C. Anderson
Publikováno v:
OncoImmunology, Vol 7, Iss 2 (2018)
Both in vivo data in preclinical cancer models and in vitro data with T cells from patients with advanced cancer support a role for Tim-3 blockade in promoting effective anti-tumor immunity. Consequently, there is considerable interest in the clinica
Externí odkaz:
https://doaj.org/article/3c144a1874ea4d4292b8f6ab85913507
Akademický článek
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Autor:
Kabir Hassan Biswas, Suguna Badireddy, Abinaya Rajendran, Ganesh Srinivasan Anand, Sandhya S. Visweswariah
Publikováno v:
PeerJ, Vol 3, p e882 (2015)
GAF domains are a large family of regulatory domains, and a subset are found associated with enzymes involved in cyclic nucleotide (cNMP) metabolism such as adenylyl cyclases and phosphodiesterases. CyaB2, an adenylyl cyclase from Anabaena, contains
Externí odkaz:
https://doaj.org/article/4353b7ab3aca40b99ce528ca051a046c
Autor:
Firdaus Samsudin, Gu Yue, Wong Y Hwa, Peter J. Bond, Nikhil Kumar Tulsian, Palur Venkata Raghuvamsi, Ganesh S. Anand, Kiren Purushotorman, Mary M Kozma, Xinlei Qian, Julien Lescar, Paul A. MacAry
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The Spike (S) protein is the main handle for SARS-CoV-2 to enter host cells through surface ACE2 receptors. How ACE2 binding activates proteolysis of S protein is unknown. Here, we have mapped the S:ACE2 interface and uncovered long-range allosteric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024c6ae3bb6efa64460e561ceb8f4efc
https://elifesciences.org/articles/63646
https://elifesciences.org/articles/63646
Akademický článek
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Akademický článek
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