Zobrazeno 1 - 10
of 686
pro vyhledávání: '"HDX-MS"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3118-3131 (2024)
The gene PIK3CA, encoding the catalytic subunit p110α of PI3Kα, is the second most frequently mutated gene in cancer, with the highest frequency oncogenic mutants occurring in the C-terminus of the kinase domain. The C-terminus has a dual function
Externí odkaz:
https://doaj.org/article/fb12b9be2c5242a0880c041b2806ad1a
Autor:
Bo Zhao, Joy Yoon, Bojie Zhang, Youmi Moon, Yue Fu, Yinyin Li, Yunlong Zhao, Hui Xiao, Ning Li
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Methionine oxidation can substantially alter the structure and functionality of monoclonal antibodies (mAbs), especially when it occurs in the complementarity-determining regions (CDRs). It is imperative to fully understand the effects of methionine
Externí odkaz:
https://doaj.org/article/1ec92c06f523461786a1034aaa3d9648
Publikováno v:
Biomimetics, Vol 9, Iss 8, p 485 (2024)
Tick Anticoagulant Peptide (TAP), a 60-amino acid protein from the soft tick Ornithodoros moubata, inhibits activated coagulation factor X (fXa) with almost absolute specificity. Despite TAP and Bovine Pancreatic Trypsin Inhibitor (BPTI) (i.e., the p
Externí odkaz:
https://doaj.org/article/8d2d56c490f24a4f82160436c8548413
Autor:
Bo Zhao, Yunlong Zhao, Stephanie Adaniya, Yue Fu, Youmi Moon, Justin Heftel, Shuzhen Chen, Hui Xiao, Ning Li
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTDevelopment of novel bispecific antibody (bsAb) platforms offers unprecedented opportunities for a wide variety of therapeutic applications. However, the expression and manufacturing of bsAbs with desired structures can be challenging. Owing
Externí odkaz:
https://doaj.org/article/ac36492a969c474db420c91b1e460110
Autor:
Saw Yen Ow, Eugene A. Kapp, Vesna Tomasetig, Anton Zalewski, Jason Simmonds, Con Panousis, Michael J. Wilson, Andrew D. Nash, Matthias Pelzing
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTHageman factor (FXII) is an essential component in the intrinsic coagulation cascade and a therapeutic target for the prophylactic treatment of hereditary angioedema (HAE). CSL312 (garadacimab) is a novel high-affinity human antibody capable
Externí odkaz:
https://doaj.org/article/0c07c3f8278b450db8ee8af9dbb53b06
Autor:
Shannon C. David, Oscar Vadas, Irina Glas, Aline Schaub, Beiping Luo, Giovanni D'angelo, Jonathan Paz Montoya, Nir Bluvshtein, Walter Hugentobler, Liviana K. Klein, Ghislain Motos, Marie Pohl, Kalliopi Violaki, Athanasios Nenes, Ulrich K. Krieger, Silke Stertz, Thomas Peter, Tamar Kohn
Publikováno v:
mSphere, Vol 8, Iss 5 (2023)
ABSTRACT Multiple respiratory viruses, including influenza A virus (IAV), can be transmitted via expiratory aerosol particles, and aerosol pH was recently identified as a major factor influencing airborne virus infectivity. Indoors, small exhaled aer
Externí odkaz:
https://doaj.org/article/a6bed9043c63434cac37f831c28bbc45
Autor:
Noah J Harris, Meredith L Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E Moeller, Eleanor Sheeky, Scott D Hansen, Calvin K Yip, John E Burke
Publikováno v:
eLife, Vol 12 (2023)
PI3Kγ is a critical immune signaling enzyme activated downstream of diverse cell surface molecules, including Ras, PKCβ activated by the IgE receptor, and Gβγ subunits released from activated GPCRs. PI3Kγ can form two distinct complexes, with th
Externí odkaz:
https://doaj.org/article/e0ae711fee134081811275437049e492
Autor:
Elizabeth A. Komives
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Thrombin is a serine protease that catalyzes a large number of different reactions including proteolytic cleave of fibrinogen to make the fibrin clot (procoagulant activity), of the protease activated receptors (for cell signaling) and of protein C g
Externí odkaz:
https://doaj.org/article/32a52ad047e74b93a0be24d7674c281f
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