Zobrazeno 1 - 10
of 36
pro vyhledávání: '"HDM, House dust mite"'
Autor:
Clare M. Lloyd, Simone A. Walker, Robert A. Oliver, James Cook, Anne O'Garra, Nicoletta Bruno, Sejal Saglani, Helen Stölting, William J. Branchett, Matthias Mack
Publikováno v:
The Journal of Allergy and Clinical Immunology
Background Early life represents a major risk window for asthma development. However, the mechanisms controlling the threshold for establishment of allergic airway inflammation in early life are incompletely understood. Airway macrophages (AMs) regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611fb2a95f706e51bb7280f80ae39d5b
https://doi.org/10.1016/j.jaci.2021.01.026
https://doi.org/10.1016/j.jaci.2021.01.026
Autor:
Christopher Green, Deanna L. Davis, Sarah Spiegel, Michael Maceyka, Usha Mahawar, Clement Oyeniran, Binks W. Wattenberg, Cynthia Weigel, Jason Newton, Briana N. James
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100082-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100082-(2021)
The serine palmitoyltransferase (SPT) complex catalyzes the rate-limiting step in the de novo biosynthesis of ceramides, the precursors of sphingolipids. The mammalian ORMDL isoforms (ORMDL1-3) are negative regulators of SPT. However, the roles of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db4a783bcfe3cd38f08db6299eb2fbf
http://europepmc.org/articles/PMC8167824
http://europepmc.org/articles/PMC8167824
Publikováno v:
Annals of Allergy, Asthma & Immunology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f21feed4be085d75d1002c6fec9fe7a1
http://europepmc.org/articles/PMC7804376
http://europepmc.org/articles/PMC7804376
Autor:
Ji Hye Kim, Jung Won Park, Thomas S. Kupper, Jungsoo Lee, Ke Lun Zhang, Youdong Pan, Kyung Hee Park, Seo Hyeong Kim, Jongsun Lee, Ji Yeon Noh, HyeRan Kim, Chang Ook Park, Bomi Kim, Kyoung Yong Jeong, Kwang Hoon Lee, Howard Chu, Zheng-wang Sun
Publikováno v:
EBioMedicine, Vol 58, Iss, Pp 102879-(2020)
EBioMedicine
EBioMedicine
Background While the incidence of patients with atopic dermatitis (AD) with atopic march (AM) showing respiratory allergy is steadily rising, the pathomechanism is still unknown. There are currently no biomarkers to predict progression of AM. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09dac8f75a65d7395b7b64a1ba4bc1a
http://www.sciencedirect.com/science/article/pii/S2352396420302541
http://www.sciencedirect.com/science/article/pii/S2352396420302541
Autor:
Carolin Bergougnan, Elke Hümmer, Rosalie Riepl, Claudia Traidl-Hoffmann, Dominik Böck, Avidan U. Neumann, Anna Weigl, Johannes Zenk, Stefanie Gilles, Alexander Hartwig, Selina Eisenbart, Athanasios Damialis, Lena Griesbaum, Daniela Dittlein
Publikováno v:
The World Allergy Organization Journal
World Allergy Organiz. J. 13:100109 (2020)
World Allergy Organization Journal, Vol 13, Iss 3, Pp-(2020)
World Allergy Organiz. J. 13:100109 (2020)
World Allergy Organization Journal, Vol 13, Iss 3, Pp-(2020)
The epithelial cell-derived cytokine milieu has been discussed as a “master switch” in the development of allergic disease.To understand the role of innate immune response in nasal epithelial cells during allergic inflammation, we created and est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae6e593eaab00a716603b93f3759754
http://europepmc.org/articles/PMC7063333
http://europepmc.org/articles/PMC7063333
Autor:
Celeste Porsbjerg, Benedikt Fritzsching, Marco Contoli, Mercedes Romano Rodriguez, Lisa Elliott, Sarah Buchs, Julie Rask Larsen, Nick Freemantle
Publikováno v:
The Lancet Regional Health-Europe
Fritzsching, B, Contoli, M, Porsbjerg, C, Buchs, S, Larsen, J R, Elliott, L, Rodriguez, M R & Freemantle, N 2022, ' Long-term real-world effectiveness of allergy immunotherapy in patients with allergic rhinitis and asthma : Results from the REACT study, a retrospective cohort study. ', The Lancet Regional Health-Europe, vol. 13, 100275 . https://doi.org/10.1016/j.lanepe.2021.100275
The Lancet Regional Health. Europe, Vol 13, Iss, Pp 100275-(2022)
Fritzsching, B, Contoli, M, Porsbjerg, C, Buchs, S, Larsen, J R, Elliott, L, Rodriguez, M R & Freemantle, N 2022, ' Long-term real-world effectiveness of allergy immunotherapy in patients with allergic rhinitis and asthma : Results from the REACT study, a retrospective cohort study. ', The Lancet Regional Health-Europe, vol. 13, 100275 . https://doi.org/10.1016/j.lanepe.2021.100275
The Lancet Regional Health. Europe, Vol 13, Iss, Pp 100275-(2022)
Background: Allergen immunotherapy (AIT) is the only causal treatment for respiratory allergy. Long-term real-life effectiveness of AIT remains to be demonstrated beyond the evidence from randomised controlled trials (RCTs). Methods: REACT (Real worl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffc8f543ea1923373f6920b4db91b89
https://doi.org/10.1016/j.lanepe.2021.100275
https://doi.org/10.1016/j.lanepe.2021.100275
Autor:
Natalija Novak, Irene Mittermann, Walter Keller, Christine Koessler, Pia Gattinger, Urska Bidovec Stojkovic, Rudolf Valenta, Gerhard Hofer, Peter Korošec, Christian Lupinek
Publikováno v:
EBioMedicine
EBioMedicine, vol. 39, pp. 33-43, 2019.
EBioMedicine, vol. 39, pp. 33-43, 2019.
Background: N-linked glycans present in venoms, pollen and mites are recognized by IgE antibodies from more than 20% of allergic patients but have low or no allergenic activity. Objectives: To engineer recombinant glycoproteins resembling carbohydrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66091e913a78d363388e4abd696c2d14
http://europepmc.org/articles/PMC6354707
http://europepmc.org/articles/PMC6354707
Autor:
Nimai Chandra Saha, Sanjoy Podder, Priti Mondal, Debarati Dey, Srijit Bhattacharya, Goutam Kumar Saha, Saibal Moitra
Publikováno v:
The World Allergy Organization Journal
World Allergy Organization Journal, Vol 12, Iss 12, Pp-(2019)
World Allergy Organization Journal, Vol 12, Iss 12, Pp-(2019)
Background: The diagnosis of house dust mite (HDM) allergy based on Skin prick test (SPT) is not accurate, especially in lower risk cases. Our aim is to develop and validate a predictive model to diagnose the HDM allergic symptoms (urticaria, allergi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc423a7f5ef076155a46a4736ffc12fd
https://pubmed.ncbi.nlm.nih.gov/31871535
https://pubmed.ncbi.nlm.nih.gov/31871535
Autor:
Branchett, William J., Stölting, Helen, Oliver, Robert A., Walker, Simone A., Puttur, Franz, Gregory, Lisa G., Gabryšová, Leona, Wilson, Mark S., O'Garra, Anne, Lloyd, Clare M.
Publikováno v:
The Journal of Allergy and Clinical Immunology
Background Although originally defined as a type 2 (T2) immune-mediated condition, non-T2 cytokines, such as IFN-γ and IL-17A, have been implicated in asthma pathogenesis, particularly in patients with severe disease. IL-10 regulates TH cell phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0a7c940fb49fc00fa7f95debf0466019
https://pubmed.ncbi.nlm.nih.gov/31812572
https://pubmed.ncbi.nlm.nih.gov/31812572
Autor:
Sandisiwe Mangali, Martyna Scibiorek, Frank Kirstein, Amkele Ngomti, Jermaine Khumalo, Sabelo Hadebe, Frank Brombacher, Hlumani Ndlovu, Nontobeko Mthembu
Publikováno v:
The Journal of Allergy and Clinical Immunology
Background B cells play an important role in allergies through secretion of IgE. IL-4 receptor α (IL-4Rα) is key in allergic asthma and regulates type 2 cytokine production, IgE secretion, and airway hyperresponsiveness. IL-4 activation of B cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad3ec83f4328c2fc8eb949e8974ffd7
https://doi.org/10.1016/j.jaci.2020.12.635
https://doi.org/10.1016/j.jaci.2020.12.635