Zobrazeno 1 - 10
of 1 779
pro vyhledávání: '"HDACs"'
Publikováno v:
Journal of Dental Sciences, Vol 19, Iss 3, Pp 1680-1690 (2024)
Background/purpose: The acetylation of histone H3 proteins keeps local chromatin regions open and accessible, thereby facilitating transcriptional events. We recently reported integrative epigenomic and transcriptome analyses of differentiating denta
Externí odkaz:
https://doaj.org/article/a86310a04388486989387a53e63d3733
Autor:
Kukkala Kiran Kumar, Elhadi Husein Aburawi, Milos Ljubisavljevic, Melvin Khee Shing Leow, Xu Feng, Suraiya Anjum Ansari, Bright Starling Emerald
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-31 (2024)
Abstract Diabetes mellitus is a chronic disease that impairs metabolism, and its prevalence has reached an epidemic proportion globally. Most people affected are with type 2 diabetes mellitus (T2DM), which is caused by a decline in the numbers or fun
Externí odkaz:
https://doaj.org/article/0bc565514e6c413996838412b83b87a1
Publikováno v:
Heliyon, Vol 10, Iss 21, Pp e39865- (2024)
With the advancement of metagenomics and metabolomics techniques, the crucial role of the gut microbiome in intestinal, cardiovascular, and metabolic disorders has been extensively explored. Vascular calcification (VC) is common in atherosclerosis, h
Externí odkaz:
https://doaj.org/article/5406818b5e4f4016b979c4e3ec6dfe8d
Autor:
Snehal Nimal, Navanath Kumbhar, Saruchi, Shriya Rathore, Nitin Naik, Sneha Paymal, Rajesh N. Gacche
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-28 (2024)
Abstract Triple-negative breast cancer (TNBC) is a metastatic disease and a formidable treatment challenge as it does not respond to existing therapies. Epigenetic regulators play a crucial role in the progression and metastasis by modulating the exp
Externí odkaz:
https://doaj.org/article/38465e5bc7a747ea90c1cd9124417f39
Autor:
Kai-Cheng Hsu, Yun-Yi Huang, Jung-Chun Chu, Yu-Wen Huang, Jing-Lan Hu, Tony Eight Lin, Shih-Chung Yen, Jing-Ru Weng, Wei-Jan Huang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Class IIa histone deacetylases (HDACs) have been linked to tumorigenesis in various cancers. Previously, we designed phenylhydroxamic acid LH4f as a potent class IIa HDAC inhibitor. However, it also unselectively inhibited class I and class IIb HDACs
Externí odkaz:
https://doaj.org/article/2d0d3d594369440e9a61c2c583b064c2
Autor:
Fernanda Aparecida dos Santos France, Debora Kazumi Maeda, Ana Beatriz Rodrigues, Mai Ono, Franciele Lopes Nogueira Marchetti, Marcos Martins Marchetti, Allana Cristina Faustino Martins, Roberto da Silva Gomes, Cláudia Aparecida Rainho
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
A differential diet with royal jelly (RJ) during early larval development in honeybees shapes the phenotype, which is probably mediated by epigenetic regulation of gene expression. Evidence indicates that small molecules in RJ can modulate gene expre
Externí odkaz:
https://doaj.org/article/968142f9a79c4caeba42f6be39b72e3b
Autor:
Xiaojie Ren, Haokun Li, Hui Peng, Yang Yang, Hang Su, Chen Huang, Xuan Wang, Jie Zhang, Zhiyang Liu, Wenyu Wei, Ke Cheng, Tianyang Zhu, Zhenpin Lu, Zhengqiu Li, Qian Zhao, Ben Zhong Tang, Shao Q. Yao, Xiangzhi Song, Hongyan Sun
Publikováno v:
Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)
Abstract Chemoselective modification of specific residues within a given protein poses a significant challenge, as the microenvironment of amino acid residues in proteins is variable. Developing a universal molecular platform with tunable chemical wa
Externí odkaz:
https://doaj.org/article/3b7f74fc28ba4d889f83aba872f068cd
Autor:
Mayssam Hazem, Shakir M. Alwan
Publikováno v:
Al-Mustansiriyah Journal of Pharmaceutical Sciences, Vol 24, Iss 3 (2024)
A new hybrid molecule of Benzothiazole cross-linked with hydroxamic acid through an amino acid or aminoalkanoic acid were synthesised. All the synthesized hybrid molecules (1-5) were subjected to molecular docking studies to evaluate their binding af
Externí odkaz:
https://doaj.org/article/dea7fa46a94540dcaa0779d295de9fe3
Publikováno v:
Cells, Vol 13, Iss 19, p 1644 (2024)
Over the past two decades, epigenetic regulation has become a rapidly growing and influential field in biology and medicine. One key mechanism involves the acetylation and deacetylation of lysine residues on histone core proteins and other critical p
Externí odkaz:
https://doaj.org/article/71f3e07a51a84f9aa36cecf4037838d1
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