Zobrazeno 1 - 10
of 1 280
pro vyhledávání: '"HDAC8"'
Autor:
Debasmita Naik, Arunasree M. Kalle
Publikováno v:
Non-coding RNA Research, Vol 9, Iss 3, Pp 732-743 (2024)
Cervical cancer, a leading global cause of female mortality, exhibits diverse molecular aberrations influencing gene expression and signaling pathways. Epigenetic factors, including histone deacetylases (HDACs) such as HDAC8 and HDAC6, along with mic
Externí odkaz:
https://doaj.org/article/0bad0d41f1d3492fbedfcc02058dd15e
Autor:
Ángela Ascaso, María Arnedo, Beatriz Puisac, Ana Latorre-Pellicer, Julia del Rincón, Gloria Bueno-Lozano, Juan Pié, Feliciano J. Ramos
Publikováno v:
Anales de Pediatría (English Edition), Vol 100, Iss 5, Pp 352-362 (2024)
Cornelia de Lange syndrome (CdLS) is a rare congenital developmental disorder with multisystemic involvement. The clinical presentation is highly variable, but the classic phenotype, characterized by distinctive craniofacial features, pre- and postna
Externí odkaz:
https://doaj.org/article/b32335af8e744f76992bc585fbcb8e14
Autor:
Kang Qian, Wei Li, Shangqing Ren, Weilin Peng, Bei Qing, Xinlin Liu, Xiong Wei, Liang Zhu, Yapeng Wang, Xin Jin
Publikováno v:
Advanced Science, Vol 11, Iss 36, Pp n/a-n/a (2024)
Abstract Drug resistance after long‐term use of Tyrosine kinase inhibitors (TKIs) has become an obstacle for prolonging the survival time of patients with clear cell renal cell carcinoma (ccRCC). Here, genome‐wide CRISPR‐based screening to reve
Externí odkaz:
https://doaj.org/article/95bd18839c4745f4947a5dc59661117f
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundOverexpression of monopolar spindle 1 (MPS1) and histone deacetylase 8 (HDAC8) is associated with the proliferation of liver cancer cells, so simultaneous inhibition of both MPS1 and HDAC8 could offer a promising therapeutic approach for th
Externí odkaz:
https://doaj.org/article/b8dbf9d90b894eada1a37b0b880b3879
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37528- (2024)
Zinc finger protein 521 (ZNF521) participates in the self-renewal of hematopoietic stem cells, and its abnormal expression has been implicated to promote leukemia. However, the specific role of ZNF521 in leukemia has not been fully understood. In thi
Externí odkaz:
https://doaj.org/article/009a8c07fc6f41c6b84ed0837f1b9ed5
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116839- (2024)
Dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) and histone deacetylase 8 (HDAC8) have been shown to be associated with the development of several cancers. Here, we identified a dual-target DYRK2/HDAC8 inhibitor (DYC-1) through a
Externí odkaz:
https://doaj.org/article/58ff2c3710c44972a679df787b149ddb
Autor:
Huijun Zhang, Tingli Liu, Xinhua Liu, Fenfen You, Jiaheng Yang, Nan Zhang, Ying Huang, Gaofeng Liang
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Histone deacetylates family proteins have been studied for their function in regulating viral replication by deacetylating non-histone proteins. RIG-I (Retinoic acid-inducible gene I) is a critical protein in RNA virus-induced innate antiviral signal
Externí odkaz:
https://doaj.org/article/d69f0737e6664db4b31932d00081130b
Autor:
Liang-Huan Wu, Yu-Wen Cheng, Fan-Li Lin, Kai-Cheng Hsu, Mong-Heng Wang, Jing-Lun Yen, Tsung-Jen Wang, Tony Eight Lin, Yi-Chien Liu, Wei-Jan Huang, George Hsiao
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116538- (2024)
Glaucoma is considered a neurodegenerative disease characterized by progressive visual field defects that may lead to blindness. Although controlling intraocular pressure (IOP) is the mainstay of glaucoma treatment, some glaucoma patients have unmet
Externí odkaz:
https://doaj.org/article/1f572671db9b44c28ad07161acd206b1
Publikováno v:
Al-Mustansiriyah Journal of Pharmaceutical Sciences, Vol 24, Iss 2 (2024)
This study involved the development of innovative compounds consisting of dipeptide cross-links combined with hydroxamic acid. Our objective was to assess their binding affinities with histone deacetylase 8 (HDAC8) by conducting a docking study, comp
Externí odkaz:
https://doaj.org/article/533227a841d44413be19c7f280b35531
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8145 (2024)
In patients with endometriosis, refluxed endometrial fragments evade host immunosurveillance, developing into endometriotic lesions. However, the mechanisms underlying this evasion have not been fully elucidated. N-Myc and STAT Interactor (NMI) have
Externí odkaz:
https://doaj.org/article/4dfff777ae924c95b9f791060bc491e5