Zobrazeno 1 - 10
of 2 955
pro vyhledávání: '"HDAC4"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Background: Histone deacetylase 4 (HDAC4) and histone deacetylase 5 (HDAC5) are two isoforms of class IIa HDACs, and LMK235 is an HDAC inhibitor with higher selectivity for HDAC4/5. This study aimed to explore the expression and subcellular
Externí odkaz:
https://doaj.org/article/6cfadd4f34824f219325a01672b312d5
Autor:
Chongwei Chen, Yue Li, Teng Feng, Xinping Chen, Chengwei Li, Lu Li, Mengbo Zhu, Yaqiong Chang, Shaowei Wang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Osteoblasts and osteoclasts play an important role in maintaining the structural integrity of bone tissue, in which osteoclasts degrade bone structure and osteoblasts restore bone tissue. The imbalance of osteoblast and osteoclast function c
Externí odkaz:
https://doaj.org/article/efb5806d00e94209848edd83952e5bd9
Publikováno v:
Archives of Medical Science, Vol 20, Iss 3, Pp 847-862 (2024)
Introduction Pancreatic cancer (PC) is a common malignant tumor of the digestive system, posing a serious threat to the life of patients. This study aims to investigate the role of LINC00847 and the LINC00847/miR-455-3p/HDAC4 mechanism in PC progress
Externí odkaz:
https://doaj.org/article/c9861e682559402492a0c7033349f541
Autor:
Wenhong Liu, Guanghua Luo
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101059- (2024)
Background: Breast cancer is a malignancy with a generally poor prognosis. With the advancement of molecular research, we have gained deeper insights into the cellular processes that drive breast cancer development. However, the precise mechanisms re
Externí odkaz:
https://doaj.org/article/a91c15d75a3a46c4a7762829e7a627a9
Autor:
Yongshun Wang, Jie Yuan, Huadong Liu, Jie Chen, Jieru Zou, Xiaoyi Zeng, Lei Du, Xin Sun, Zhengyuan Xia, Qingshan Geng, Yin Cai, Jingjin Liu
Publikováno v:
Genes and Diseases, Vol 11, Iss 6, Pp 101100- (2024)
High-intensity interval training (HIIT) has been found to be more effective in relieving heart failure (HF) symptoms, than moderate-intensity continuous aerobic training (MICT). Additionally, higher meteorin-like protein (Metrnl) levels are seen afte
Externí odkaz:
https://doaj.org/article/9a40507f78c145cb8327de98fd1e2e26
Autor:
Wei Huang, MM, Xi Chen, MM, Zizhen Liu, MM, Changwu Li, MD, Xin Wei, MD, Jiabin Zhan, MD, Quan Qiu, MM, Jing Zheng, MD
Publikováno v:
World Allergy Organization Journal, Vol 17, Iss 9, Pp 100963- (2024)
Background: Allergic rhinitis (AR) is a global health issue affecting millions of individuals worldwide. Pyroptosis has emerged as a major player in the development of AR, and targeting its inhibition with specific drugs holds promise for AR treatmen
Externí odkaz:
https://doaj.org/article/7b368af8698b4a3bb097d8e32d974c67
Autor:
Xinping Chen, Chengwei Li, Jiyu Zhao, Yunxiang Liu, Zhizhong Zhao, Zhenyu Wang, Yue Li, Yunfei Wang, Lixia Guo, Lu Li, Chongwei Chen, Bing Bai, Shaowei Wang
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Delayed repair of fractures seriously impacts patients’ health and significantly increases financial burdens. Consequently, there is a growing clinical demand for effective fracture treatment. While current materials used for fracture repa
Externí odkaz:
https://doaj.org/article/195dba818fce46be9389c627a95b6f8b
Akademický článek
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Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-24 (2024)
Abstract Background Dysregulation of nucleocytoplasmic shuttling of histone deacetylase 4 (HDAC4) is associated with several neurodevelopmental and neurodegenerative disorders. Consequently, understanding the roles of nuclear and cytoplasmic HDAC4 al
Externí odkaz:
https://doaj.org/article/d76c16a861864241b5f042adf8f0c479
Autor:
Hao Yuan, Chuang Chen, Haonan Li, Gexi Qu, Luyao Chen, Yaxing Liu, Yufeng Zhang, Qiang Zhao, Changhong Lian, Aifang Ji, Xuedong Hou, Xinjian Liu, Kuirong Jiang, Yi Zhu, Yuan He
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-24 (2024)
Abstract Background Pancreatic cancer (PC) is an extremely malignant tumor with low survival rate. Effective biomarkers and therapeutic targets for PC are lacking. The roles of circular RNAs (circRNAs) in cancers have been explored in various studies
Externí odkaz:
https://doaj.org/article/ba40859aff4344fdbd4b7e7b71a3aaee