Zobrazeno 1 - 10
of 3 044
pro vyhledávání: '"HDAC1"'
Autor:
Qiman Dong, Xiaoqiong Yang, Lingling Wang, Qingye Zhang, Nannan Zhao, Shanshan Nai, Xiaoling Du, Lingyi Chen
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Cellular metabolism regulates the pluripotency of embryonic stem cells (ESCs). Yet, how metabolism regulates the transition among different pluripotent states remains elusive. It has been shown that protein lactylation, which uses
Externí odkaz:
https://doaj.org/article/5ccce9fe7be348ceba7e34d7305c065a
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The methyltransferase Wilms’ tumor 1-associated protein (WTAP) has been reported to be dysregulated in various tumors. However, its role in renal cell carcinoma (RCC) remains elusive. Here, we explored whether WTAP was upregulated in RCC s
Externí odkaz:
https://doaj.org/article/2aedd31704f645d7ad7a1bb4aae26587
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background The development of acquired EGFR-TKI treatment resistance is still a major clinical challenge in the treatment of non-small cell lung cancer (NSCLC). This study aimed to investigate the role of HDAC1/FOXK1/miR-33a signaling in EGF
Externí odkaz:
https://doaj.org/article/955f165724ae455f867c0f8f8221034a
Autor:
Yiru Kong, Rongrong Jiang, Hui Zhou, Mengxi Ge, Hao Lin, Yu Wang, Rongrong Yao, Qing Wang, Xiaohua Liang, Jing Li, Xinli Zhou
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Lung cancer stands as the second most prevalent malignant neoplasm worldwide. Addressing the underlying mechanisms propelling the progression of non-small cell lung cancer is of paramount importance. In this study, we have elucida
Externí odkaz:
https://doaj.org/article/dbff9bdb042b47298cdeafbdb455e16a
Publikováno v:
Brain Research Bulletin, Vol 211, Iss , Pp 110944- (2024)
Ischemic stroke is a serious cerebrovascular condition. Isobavachalcone (ISO) has been documented to exhibit an anti-inflammatory effect across a variety of diseases; however, its protective impact on ischemic stroke remains unexplored. In this study
Externí odkaz:
https://doaj.org/article/69758b02ceb9491f8d31cb421f19b68d
Autor:
Sara Rossi, Vanessa Tatangelo, Maria Dichiara, Stefania Butini, Sandra Gemma, Simone Brogi, Silvia Pasquini, Martina Cappello, Fabrizio Vincenzi, Katia Varani, Ludovica Lopresti, Margherita Malchiodi, Chiara Carrara, Alessandro Gozzetti, Monica Bocchia, Giuseppe Marotta, Laura Patrussi, Gabriele Carullo, Cosima T. Baldari, Giuseppe Campiani
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116537- (2024)
Chronic Lymphocytic Leukemia (CLL) patients have a defective expression of the proapoptotic protein p66Shc and of its transcriptional factor STAT4, which evoke molecular abnormalities, impairing apoptosis and worsening disease prognosis and severity.
Externí odkaz:
https://doaj.org/article/5b5fa73fa7a44b40b6f5ece58f9ee513
Autor:
Rachid Haloui, Kaouakeb ElKhattabi, Khaoula Mkhayar, Ossama Daoui, Samir Chtita, Amal Haoudi, Souad Elkhattabi
Publikováno v:
Scientific African, Vol 23, Iss , Pp e01990- (2024)
Histone deacetylase (HDAC) dysregulation plays an important role in cancer progression and is an important therapeutic target for anticancer drug development. A series of molecules derived from styrylpyridine have HDAC inhibitory activity for the tre
Externí odkaz:
https://doaj.org/article/14c25473a8cd4dd298cd7d749fed1096
Autor:
Liangliang Xu, Peng Wang, Li Li, Lian Li, Yang Huang, Yanfang Zhang, Xiaobo Zheng, Pengsheng Yi, Ming Zhang, Mingqing Xu
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-22 (2023)
Abstract Background Vascular invasion is a major route for intrahepatic and distant metastasis in hepatocellular carcinoma (HCC) and is a strong negative prognostic factor. Circular RNAs (circRNAs) play important roles in tumorigenesis and metastasis
Externí odkaz:
https://doaj.org/article/6f7304e90d214f1786a81db716b7ff46
Publikováno v:
Journal of Inflammation Research, Vol Volume 16, Pp 4103-4116 (2023)
Hao-Kuang Wang,1– 3 Yu-Ting Su,4 Yu-Cheng Ho,3,5 Yung-Kuo Lee,6 Tian-Huei Chu,6 Kuang-Ti Chen,7 Cheng-Chun Wu3,5 1Department of Neurosurgery, E-DA Hospital, I-Shou University, Kaohsiung City, Taiwan; 2School of Medicine for International Students,
Externí odkaz:
https://doaj.org/article/dd876ad03192485dbca4227d68d6b56b
Publikováno v:
PeerJ, Vol 12, p e16768 (2024)
Background Recent studies have shown that activated pyroptosis in atopic dermatitis (AD) switches inflammatory processes and causes abnormal cornification and epidermal barrier dysfunction. Little research has focused on the interaction mechanism bet
Externí odkaz:
https://doaj.org/article/fe9870e7cc3b4277afe6181aadf1dcfa