Zobrazeno 1 - 6
of 6
pro vyhledávání: '"HDAC Inhibitor AR-42"'
Autor:
Ming Poi, Wenjun Ni, Flavia Pichiorri, Mitch A. Phelps, Jiang Wang, Douglas W. Sborov, Don M. Benson, Pierluigi Porcu, Craig C. Hofmeister, Joseph M. Flynn, Robert A. Baiocchi, Erinn M. Hade, Amir Mortazavi, Christopher C. Coss, Soun Khountham, Alessandro Canella, John C. Byrd, Xiaokui Mo, Leslie A. Andritsos, Beth A. Christian, Zhongfa Liu
Publikováno v:
Leukemia & Lymphoma. 58:2310-2318
Histone deacetylase inhibitors (HDACi) have proven activity in hematologic malignancies, and their FDA approval in multiple myeloma (MM) and T-cell lymphoma highlights the need for further development of this drug class. We investigated AR-42, an ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4bfce3a5e0ab0d2340ced1b324cba9
https://doi.org/10.1080/10428194.2017.1298751
https://doi.org/10.1080/10428194.2017.1298751
Autor:
Luciano Cascione, Jessica Consiglio, Nicola Zanesi, Yvonne A. Efebera, Lara Rizzotto, Andrew Stiff, Flavia Pichiorri, Alessandro Canella, Balveen Kaur, Enrico Caserta, John C. Byrd, Hector Cordero Nieves, Hanna S. Radomska, Xiaokui Mo, Volinia Stefano, Emily Smith, Craig C. Hofmeister, Douglas W. Sborov
Publikováno v:
Oncotarget
Multiple myeloma (MM) is a hematological malignancy of plasma cells in the bone marrow. Despite multiple treatment options, MM is inevitably associated with drug resistance and poor outcomes. Histone deacetylase inhibitors (HDACi's) are promising nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d87e0ef66060c0ef6929be20daec73
https://pubmed.ncbi.nlm.nih.gov/26429859
https://pubmed.ncbi.nlm.nih.gov/26429859
Publikováno v:
Biochemical and biophysical research communications. 463(4)
In the current study, we investigated the potential activity of AR-42, a novel histone deacetylase (HDAC) inhibitor, against colon cancer cells. Our in vitro results showed that AR-42 induced ceramide production, exerted potent anti-proliferative and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19b3ebbd629b3fdaedc58a905fd3e05
https://pubmed.ncbi.nlm.nih.gov/26026677
https://pubmed.ncbi.nlm.nih.gov/26026677
Autor:
Flavia Pichiorri, Luciano Cascione, Yvonne A. Efebera, Michael R. Grever, Douglas W. Sborov, John C. Byrd, Don M. Benson, Jessica Consiglio, Emily Smith, Craig C. Hofmeister, Wenjun Ni, Mo Xiaokui, Zhongfa Liu, Alessandro Canella, Lara Rizzotto, Hector M. Cordero-Nieves
Publikováno v:
Blood. 124:3377-3377
Introduction: The first FDA-approved deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA, Vorinostat), was shown to be effective in vitro by a number of anti-neoplastic mechanisms. Despite minimal single-agent activity in multiple my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0809ada8b03745a06024130700a03ded
https://doi.org/10.1182/blood.v124.21.3377.3377
https://doi.org/10.1182/blood.v124.21.3377.3377
Autor:
Ching-Shih Chen, Ralf Bundschuh, Yu-Chou Tseng, Samuel K. Kulp, Tanios Bekaii-Saab, Wei He, Guido Marcucci, Pearlly S. Yan, Denis C. Guttridge, I-Lu Lai, David Frankhouser
Publikováno v:
Cancer Research. 74:5540-5540
Background: Cachexia occurs in more than 50% of cancer patients. Cachexia is characterized by severe loss of weight and skeletal muscle that is not reversed by nutritional support, and contributes significantly to morbidity and mortality. The develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f655cffba0c15d366579139c16676a40
https://doi.org/10.1158/1538-7445.am2014-5540
https://doi.org/10.1158/1538-7445.am2014-5540
Autor:
Ching-Shih Chen, Samuel K. Kulp, Jaime F. Modiano, Cheryl A. London, William C. Kisseberth, Sridhar Murahari, Aimee L. Jalkanen
Publikováno v:
BMC Cancer
Background Osteosarcoma (OS) is the most common primary bone tumor in both humans and dogs and is the second leading cause of cancer related deaths in children and young adults. Limb sparing surgery along with chemotherapy has been the mainstay of tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef961d6ca59c131ce64857a2679f0b4b