Zobrazeno 1 - 10
of 190
pro vyhledávání: '"HDAC, Histone Deacetylase"'
Autor:
Flavia Trionfetti, Tonino Alonzi, Giulio Bontempi, Michela Terri, Cecilia Battistelli, Claudia Montaldo, Federica Repele, Dante Rotili, Sergio Valente, Clemens Zwergel, Giulia Matusali, Fabrizio Maggi, Delia Goletti, Marco Tripodi, Antonello Mai, Raffaele Strippoli
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
BackgroundDespite the significant progress achieved in understanding the pathology and clinical management of SARS-CoV-2 infection, still pathogenic and clinical issues need to be clarified. Treatment with modulators of epigenetic targets, i.e., epid
Externí odkaz:
https://doaj.org/article/31d5bba3c72849e2ab6a5faf175fe1bc
Autor:
Cristina Pablo Tortola, Britta Fielitz, Yi Li, Julia Rüdebusch, Friedrich C. Luft, Jens Fielitz
Publikováno v:
Frontiers in Physiology, Vol 11 (2021)
RationaleThe ubiquitin–proteasome system (UPS) is responsible for skeletal muscle atrophy. We showed earlier that the transcription factor EB (TFEB) plays a role by increasing E3 ubiquitin ligase muscle really interesting new gene-finger 1(MuRF1)/t
Externí odkaz:
https://doaj.org/article/9c8f21dc2a994445b66f5ce940b441ef
Publikováno v:
Journal of Advanced Research
Graphical abstract
Introduction Neomenthol, a cyclic monoterpenoid, is a stereoisomer of menthol present in the essential oil of Mentha spp. It is used in food as a flavoring agent, in cosmetics and medicines because of its cooling effects. Howe
Introduction Neomenthol, a cyclic monoterpenoid, is a stereoisomer of menthol present in the essential oil of Mentha spp. It is used in food as a flavoring agent, in cosmetics and medicines because of its cooling effects. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7618e7dc6e2d535e1930d5f8c2bf7d7e
https://doi.org/10.1016/j.jare.2021.06.003
https://doi.org/10.1016/j.jare.2021.06.003
Autor:
Banerjee, Riddhidev
Despite steady advancements that are being made every year, currently available cancer treatment strategies have major limitations. Selective targeting of cancer cells without affecting normal cells has always proven to be a daunting task. Histone de
Autor:
Daniel J. Lisko, Bruce A. Vallance, Kevin Tsai, Laura Cook, Alana Schick, Kevan Jacobson, Genelle R Healey
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1251-1266 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1251-1266 (2021)
Background & Aims Exclusive enteral nutrition (EEN) is used to treat pediatric Crohn’s disease (CD), but therapeutic benefits are variable, and EEN can lead to microbial dysbiosis. Because of reported lower efficacy EEN is not routinely used to tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098178806e4a3d05fe4f185089a5572e
http://europepmc.org/articles/PMC8453203
http://europepmc.org/articles/PMC8453203
Autor:
Xin Lin, Hua Xiang, Lizhe Zhu, Zhenbang Li, Xinyu Li, Kun Xi, Yu Chen, Guoshun Luo, Hanlin Wei, Maoxu Xiao
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1300-1314 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
HMG-CoA reductase (HMGCR) protein is usually upregulated after statin (HMGCR inhibitor) treatment, which inevitably diminishes its therapeutic efficacy, provoking the need for higher doses associated with adverse effects. The proteolysis targeting ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6312f6152cec18a667ff549cdcda8ade
http://www.sciencedirect.com/science/article/pii/S2211383520307772
http://www.sciencedirect.com/science/article/pii/S2211383520307772
Autor:
Gregory Tiao, Talita Ferreira Margues Aguiar, Alexander Bondoc, Soona Shin, Maria Prates Rivas, Michael E. Johnston, Ruhi Gulati, Meenasri Kumbaji, Ana Cristina Victorino Krepischi, James I. Geller, Lubov Timchenko, Nikolai Timchenko
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1669-1682 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1669-1682 (2021)
Background & Aims Epigenetic regulation of gene expression plays a critical role in the development of liver cancer; however, the molecular mechanisms of epigenetic-driven liver cancers are not well understood. The aims of this study were to examine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1de4a5ee700fbcde5ea9b038cd2eb1
https://doi.org/10.1016/j.jcmgh.2021.06.026
https://doi.org/10.1016/j.jcmgh.2021.06.026
Autor:
Sara M. Dann, Zheng Zhou, Suxia Yao, Wenjing Yang, Anthony J. Bilotta, Yu Yu, Xiaojing Zhao, Chunyan Ma, Yingzi Cong, Yanbo Yu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1023-1044 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background and Aims Gut bacteria-derived short-chain fatty acids (SCFAs) play crucial roles in the maintenance of intestinal homeostasis. However, how SCFAs regulate epithelial turnover and tissue repair remain incompletely understood. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d4114ca3e9339e1b8954fbfbdd4b9d
http://www.sciencedirect.com/science/article/pii/S2352345X20301909
http://www.sciencedirect.com/science/article/pii/S2352345X20301909
Akademický článek
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Autor:
Peter Hellings, Brecht Steelant
Publikováno v:
The Journal of Allergy and Clinical Immunology
The respiratory epithelium provides a physical, functional, and immunologic barrier to protect the host from the potential harming effects of inhaled environmental particles and to guarantee maintenance of a healthy state of the host. When compromise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9965c967a9d459d8ed0ccb4f0e31f017
http://europepmc.org/articles/PMC7270816
http://europepmc.org/articles/PMC7270816