Zobrazeno 1 - 10
of 6 785
pro vyhledávání: '"HD9665-9675"'
Autor:
S. D. Kulikova, М. B. Sokol, Z. M. Kozlova, P. A. Losenkova, P. Ya. Parshinova, A. M. Poluyanov
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 3, Pp 146-155 (2024)
Introduction. Biorelevant dissolution media reconstitute the composition of the contents of the gastrointestinal tract. They are used as dissolution media in the evaluation of dissolution profiles of different dosage forms. Simulated biological fluid
Externí odkaz:
https://doaj.org/article/03d258bf279b4d44be9c3db9b114d498
Autor:
Ya. E. Reshetov, A. A. Ligacheva, E. S. Trofimova, N. S. Selivanova, S. V. Krivoshchekov, E. V. Basova, E. Yu. Sherstoboev, E. Yu. Avdeeva, I. P. Kaminsky, M. G. Danilets, M. V. Belousov
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 3, Pp 39-51 (2024)
Introduction. Representatives of the Ericaceae family are quite common in Russia and are promising for the creation of new medicines of plant origin. At the same time, only 4 of them are official. The study of biologically active substances and pharm
Externí odkaz:
https://doaj.org/article/107d53302b3c48b6b5eca3ea85e021c4
Autor:
A. V. Strelkova, E. V. Flisyuk
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 3, Pp 85-92 (2024)
Introduction. The development of defect-free film coating modes is an urgent task when transferring film-coated tablets technology. Technology transfer is an integral stage of the life cycle of any drug approved for industrial production. During the
Externí odkaz:
https://doaj.org/article/22cc9296dd064c05b23e9fe1fe4be271
Autor:
G. V. Adamov, O. L. Saybel, A. N. Babenko, E. S. Melnikov, A. I. Radimich, O. Yu. Kulyak, L. V. Krepkova
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 3, Pp 126-137 (2024)
Introduction. The development and registration of antiviral drugs is an urgent task. Flavonoids, in particular, luteolin-7-glycoside (cinaroside, luteolin-7-O-glycoside) demonstrate high broad-spectrum antiviral activity in vitro, and the industrial
Externí odkaz:
https://doaj.org/article/575addec5020478cb344cfad64f53309
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 3, Pp 93-102 (2024)
Introduction. In the pharmaceutical technology field there is great interest in polymers with mucoadhesive properties, as they increase the drug retention time on the mucosal surface and increase the bioavailability of the drug. There are various muc
Externí odkaz:
https://doaj.org/article/28b2a20f8e8947289928db884b08b1de
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 3, Pp 66-73 (2024)
Introduction. In the modern world, there are many pharmaceutical substances that have various structure. During the development of finished dosage forms (FDPs) it is necessary to take into account many factors, such as physicochemical and technologic
Externí odkaz:
https://doaj.org/article/1885e0a5721f41e0b8064edfe19aa56a
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 3, Pp 199-207 (2024)
Introduction. The presence of the active metabolite (3-hydroxyphenazepam, 3-OH-PHEN), the wide interindividual variability of the therapeutic effect of phenazepam (PHEN), as well as its active moiety in the blood, determine the relevance of therapeut
Externí odkaz:
https://doaj.org/article/14f29716d5054deab514808eb0b7f4c1
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 3, Pp 219-230 (2024)
Introduction. The study of the systemic exposure of a new original drug is an essential part of its preclinical study. 5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide is a new selective carbonic anhydrase II inhibitor for the treatment o
Externí odkaz:
https://doaj.org/article/52838cbd2d95414faabcc41820fa7e0e
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 3, Pp 208-218 (2024)
Introduction. The use of doxorubicin in clinical practice has shown cumulative and dose-dependent toxic effects on cardiomyocytes, leading to an increase of mortality risk among patients with cancer and as a resulting to restrictions in the indicatio
Externí odkaz:
https://doaj.org/article/1db5370ebe4445bd9e60a7ce61ef8018
Autor:
N. B. Melnikova, I. A. Sheferov, A. A. Emasheva, A. A. Sheferova, D. A. Panteleev, A. I. Slivkin
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 3, Pp 52-65 (2024)
Introduction. The review considered the basic concepts of drug release and kinetic modeling of this process from dosage forms (DF) according to the dissolution profile using a vertical Franz diffusion cell.Text. Drug release from dosage forms (ointme
Externí odkaz:
https://doaj.org/article/7b6bdb85bb77486ead002c9c4590c04b