First clinical study using HCV protease inhibitor danoprevir to treat COVID-19 patients

Autor: Fanghua Gong, Jinzi J. Wu, Hongyi Chen, Li Wang, Zhihua Huang, Zhicheng Zhang, Xiaodong Li, Yahong Chen

Publikováno v: Medicine

Introduction: As coronavirus disease 2019 (COVID-19) outbreak globally, repurposing approved drugs is emerging as important therapeutic options. Danoprevir boosted by ritonavir (Ganovo) is a potent hepatitis C virus (HCV) protease (NS3/4A) inhibitor,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54dd607466be103268fbfb9c7993280
http://europepmc.org/articles/PMC7710192

Why Does Industry Not Use Immobilized Transition Metal Complexes as Catalysts?

Autor: Sandra Huebner, Vittorio Farina, Johannes G. de Vries

Publikováno v: Advanced Synthesis & Catalysis. 358:3-25

Much effort has gone into the immobilization of homogeneous catalysts based on the idea that in this way the catalysts could be not only separated more easily from the product but also reused several times, thus reducing the cost of the catalyst use.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fec8e6365c206e2ccce408eee940e2e
https://doi.org/10.1002/adsc.201500846

Plasma apolipoprotein H limits HCV replication and associates with response to NS3 protease inhibitors-based therapy

Autor: Matthew L. Albert, Yoann Barthe, Armanda Casrouge, Arnaud Fontanet, Stanislas Pol, Sylvie Lagaye, Hélène Fontaine, Vincent Mallet, Philippe Sultanik, Christophe Hézode, Estelle Mottez, Laurent Abel, Etienne Gayat, Céline Dorival, Fabrice Carrat, Jean-Pierre Bronowicki, Ioannis Theodorou

Publikováno v: Liver International
Liver International, Wiley-Blackwell, 2015, 35 (7), pp.1833-1844. ⟨10.1111/liv.12759⟩
Liver International, 2015, 35 (7), pp.1833-1844. ⟨10.1111/liv.12759⟩
Liver International, Wiley-Blackwell, 2015, 35 (7), pp.1833-1844. 〈10.1111/liv.12759〉

International audience; BACKGROUND & AIMS:Chronic infection with HCV remains a public health problem with approximately 150 million people infected worldwide. HCV intersects with lipid metabolism for replication and entry; and plasma concentrations o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90633f842d8de6ea3f7f4df0ad3c882d
https://doi.org/10.1111/liv.12759

Development of a simple HPLC-UV method for the determination of the hepatitis C virus inhibitor simeprevir in human plasma

Autor: Giulio Nannetti, Silvana Pagni, Arianna Loregian, Alfredo Alberti, Saverio Giuseppe Parisi, Giorgio Palù

Publikováno v: Journal of pharmaceutical and biomedical analysis. 121

A simple high-performance liquid chromatography method for the determination of the hepatitis C virus protease inhibitor simeprevir in human plasma was developed and validated. The method involved a rapid and simple solid-phase extraction of simeprev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2517755bae90683a76115b827bbef2
https://pubmed.ncbi.nlm.nih.gov/26808069

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