Zobrazeno 1 - 10
of 358
pro vyhledávání: '"HCV protease"'
Publikováno v:
Cells, Vol 12, Iss 3, p 406 (2023)
Hepatitis C Virus NS3/NS4A, a serine protease complex, has been found to interact with many host proteins and cause various adverse effects on cellular function and immune response. For example, the cleavage of important immune factors by NS3/NS4A ha
Externí odkaz:
https://doaj.org/article/bb467e0d1c5b4c108963c0b19df875c4
Akademický článek
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Autor:
Khushboo Bafna, Kris White, Balasubramanian Harish, Romel Rosales, Theresa A. Ramelot, Thomas B. Acton, Elena Moreno, Thomas Kehrer, Lisa Miorin, Catherine A. Royer, Adolfo García-Sastre, Robert M. Krug, Gaetano T. Montelione
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109133- (2021)
Summary: Effective control of COVID-19 requires antivirals directed against SARS-CoV-2. We assessed 10 hepatitis C virus (HCV) protease-inhibitor drugs as potential SARS-CoV-2 antivirals. There is a striking structural similarity of the substrate bin
Externí odkaz:
https://doaj.org/article/f487dc0be1e94d1382aa92c5a7ce55f1
Viral Interference of Hepatitis C and E Virus Replication in Novel Experimental Co-Infection Systems
Autor:
Thomas Burkard, Nora Proske, Kathrin Resner, Laura Collignon, Leonard Knegendorf, Martina Friesland, Lieven Verhoye, Ibrahim M. Sayed, Yannick Brüggemann, Maximilian K. Nocke, Patrick Behrendt, Heiner Wedemeyer, Philip Meuleman, Daniel Todt, Eike Steinmann
Publikováno v:
Cells, Vol 11, Iss 6, p 927 (2022)
Background: Hepatitis C virus (HCV) constitutes a global health problem, while hepatitis E virus (HEV) is the major cause of acute viral hepatitis globally. HCV/HEV co-infections have been poorly characterized, as they are hampered by the lack of rob
Externí odkaz:
https://doaj.org/article/45b8a704a7ee4b389175e16cb3fa3413
Publikováno v:
Molecules, Vol 25, Iss 11, p 2529 (2020)
The coronavirus disease, COVID-19, caused by the novel coronavirus SARS-CoV-2, which first emerged in Wuhan, China and was made known to the World in December 2019 turned into a pandemic causing more than 126,124 deaths worldwide up to April 16th, 20
Externí odkaz:
https://doaj.org/article/221e5f7396ed4a0e90952813813f29f0
Autor:
Surasak Jittavisutthikul, Jeeraphong Thanongsaksrikul, Kanyarat Thueng-in, Monrat Chulanetra, Potjanee Srimanote, Watee Seesuay, Aijaz Ahmad Malik, Wanpen Chaicumpa
Publikováno v:
Viruses, Vol 7, Iss 4, Pp 2030-2056 (2015)
There is a need for safe and broadly effective anti-HCV agents that can cope with genetic multiplicity and mutations of the virus. In this study, humanized-camel VHHs to genotype 3a HCV serine protease were produced and were linked molecularly to a c
Externí odkaz:
https://doaj.org/article/b2d739c653824504bfead8e18c42ccca
Publikováno v:
Терапевтический архив, Vol 86, Iss 10, Pp 77-81 (2014)
The incidence of chronic viral hepatitides (CVH) has increased 2.2-fold in the Russian Federation over the past decade. This increase is mainly determined by an almost threefold rise in the incidence of chronic hepatitis C (CHC): from 12.9 in 1999 to
Externí odkaz:
https://doaj.org/article/a908ff40e99d458aa5827dd28a564765
Akademický článek
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Autor:
Rodger F. Henry, Chen Ding, Sanjay R. Chemburkar, Shuang Chen, Hongqiang Zhang, Nandkishor K. Nere, Jianzhang Mei, Kirill A. Lukin, Rajarathnam E. Reddy, David R. Hill, Matthew J. Pelc, Angelica B. Kielbus, Timothy B. Towne, Michael J. Abrahamson, Kenneth M. Engstrom, Russell D. Cink
Publikováno v:
Organic Process Research & Development. 24:1393-1404
The preceding article described the development of the large-scale synthetic route to macrocycle 3 of glecaprevir (1), a potent HCV protease inhibitor. This article describes the development of the...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::282f605e761bed3756f3a1fb8d0587d2
https://doi.org/10.1021/acs.oprd.0c00245
https://doi.org/10.1021/acs.oprd.0c00245
Autor:
Elise T Chan, Klajdi Kosovrasti, Ashley N Matthew, Adam K Hedger, Akbar Ali, Jennifer Timm, Nese Kurt Yilmaz, Sang V Vo, Desaboini Nageswara Rao, Celia A. Schiffer, Jacqueto Zephyr, Mina Henes
Publikováno v:
J Mol Biol
Third generation Hepatitis C virus (HCV) NS3/4A protease inhibitors (PIs), glecaprevir and voxilaprevir, are highly effective across genotypes and against many resistant variants. Unlike earlier PIs, these compounds have fluorine substitutions on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d973fa125773f817b32f09d7e5edd2b8
https://europepmc.org/articles/PMC9189784/
https://europepmc.org/articles/PMC9189784/
