Minimizing HCN in DIC/Oxyma mediated amide bond forming reactions

Autor: Olivier Ludemann-Hombourger, Frédéric Bihel, Jon H. Rasmussen, Marika Lundqvist, Jan Pawlas, Marion Erny

Publikováno v: Organic Process Research and Development
Organic Process Research and Development, American Chemical Society, 2020, 24 (7), pp.1341-1349. ⟨10.1021/acs.oprd.0c00227⟩

Aiming at advancing protocols for safer, environmentally sensible peptide synthesis we report our findings with regard to the occurrence of hydrogen cyanide (HCN, prussic acid) in amide bond-forming reactions mediated by diisopropylcarbodiimide (DIC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4081407389e9e4805ee38062af9a2c6
https://doi.org/10.1021/acs.oprd.0c00227