Zobrazeno 1 - 10
of 1 134
pro vyhledávání: '"HCN channels"'
Publikováno v:
Frontiers in Neuroanatomy, Vol 18 (2024)
Externí odkaz:
https://doaj.org/article/46ff6ff8b4eb4564895393aa20377265
Autor:
Colin H Peters, Rohit K Singh, Avery A Langley, William G Nichols, Hannah R Ferris, Danielle A Jeffrey, Catherine Proenza, John R Bankston
Publikováno v:
eLife, Vol 12 (2024)
Lymphoid restricted membrane protein (LRMP) is a specific regulator of the hyperpolarization-activated cyclic nucleotide-sensitive isoform 4 (HCN4) channel. LRMP prevents cAMP-dependent potentiation of HCN4, but the interaction domains, mechanisms of
Externí odkaz:
https://doaj.org/article/555c3982dc0b43a5a90322c4de213976
Publikováno v:
Frontiers in Neuroanatomy, Vol 18 (2024)
Transmembrane proteins known as hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control the movement of Na+ and K+ ions across cellular membranes. HCN channels are known to be involved in crucial physiological functions in regulati
Externí odkaz:
https://doaj.org/article/5e3c6b3494e64eef90339739b74fb149
Publikováno v:
eLife, Vol 12 (2024)
Brain somatic mutations in various components of the mTOR complex 1 (mTORC1) pathway have emerged as major causes of focal malformations of cortical development and intractable epilepsy. While these distinct gene mutations converge on excessive mTORC
Externí odkaz:
https://doaj.org/article/0bcc5fbef3d04c40b555c46acc188cbd
Akademický článek
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Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4309 (2024)
Voltage-gated potassium (Kv) channels and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels share similar structures but have opposite gating polarity. Kv channels have a strong coupling (>109) between the voltage sensor (S4) and the
Externí odkaz:
https://doaj.org/article/32fb2d13768441de88abf016b71e5215
Autor:
Paulo Pinares-Garcia, James Spyrou, Chaseley E. McKenzie, Ian C. Forster, Ming S. Soh, Erlina Mohamed Syazwan, Mohammed Atif, Christopher A. Reid
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Changes in Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) channel function have been linked to depressive-like traits, making them potential drug targets. However, there is currently no peer-reviewed data supporting the use of a small mole
Externí odkaz:
https://doaj.org/article/aa5cc88cc33c4b32b0f7f64ecf6c597e
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/b2cd7a2a02464eada660d1e2cfbcc7ad
Autor:
Irina Shemarova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15682 (2023)
Chronic heart diseases, such as coronary heart disease, heart failure, secondary arterial hypertension, and dilated and hypertrophic cardiomyopathies, are widespread and have a fairly high incidence of mortality and disability. Most of these diseases
Externí odkaz:
https://doaj.org/article/762eb867ecee4a4ab330cba6f14bdcd7