Zobrazeno 1 - 10
of 973
pro vyhledávání: '"HCN channel"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Quetiapine is a second-generation atypical antipsychotic drug that has been commonly prescribed for the treatment of schizophrenia, major depressive disorder (depression), and other psychological disorders. Targeted inhibition of hyperpolarization-ac
Externí odkaz:
https://doaj.org/article/3cd7cb449ba6406394f3815c81c0e011
Autor:
Min Cai, Yingbo Zhu, Mary Regis Shanley, Carole Morel, Stacy M. Ku, Hongxing Zhang, Yuan Shen, Allyson K. Friedman, Ming-Hu Han
Publikováno v:
Neurobiology of Stress, Vol 26, Iss , Pp 100565- (2023)
Repeated, long-term (weeks to months) exposure to standard antidepressant medications is required to achieve treatment efficacy. In contrast, acute ketamine quickly improves mood for an extended time. Recent work implicates that hyperpolarization-act
Externí odkaz:
https://doaj.org/article/2ead91ec8e4545f393f903b88152f259
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/1dfba54aa9ec4a049f00240ebc0da2a4
Autor:
Paulo Pinares-Garcia, James Spyrou, Chaseley E. McKenzie, Ian C. Forster, Ming S. Soh, Erlina Mohamed Syazwan, Mohammed Atif, Christopher A. Reid
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Changes in Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) channel function have been linked to depressive-like traits, making them potential drug targets. However, there is currently no peer-reviewed data supporting the use of a small mole
Externí odkaz:
https://doaj.org/article/aa5cc88cc33c4b32b0f7f64ecf6c597e
Akademický článek
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Autor:
Dianna E. Willis, Peter A. Goldstein
Publikováno v:
Frontiers in Pain Research, Vol 3 (2022)
The phencyclidine-derivative ketamine [2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one] was added to the World Health Organization's Model List of Essential Medicines in 1985 and is also on the Model List of Essential Medicines for Children due to
Externí odkaz:
https://doaj.org/article/833acd1b1666440bbcd4f223a02528e9
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Adenosine is an endogenous substance that regulates sleep homeostasis. It plays an important role in sleep induction under physiological condition. So far, the neural mechanisms underlying sleep-promoting effects of adenosine are not completely clear
Externí odkaz:
https://doaj.org/article/e07e683e8cf54b35ac82af29ad4d0930
Autor:
Hiroki Toyoda, Jonghwa Won, Wheedong Kim, Hayun Kim, Oscar Davy, Mitsuru Saito, Doyun Kim, Takuma Tanaka, Youngnam Kang, Seog Bae Oh
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Noradrenergic neurons in the locus coeruleus (LC) release noradrenaline (NA) that acts via volume transmission to activate extrasynaptic G-protein coupled receptors (GPCRs) in target cells throughout the brain. As the closest projection, the dorsal L
Externí odkaz:
https://doaj.org/article/8bcfbcd3be30405796881afc9db153a4
Autor:
Sultan Mayar, Mina Memarpoor-Yazdi, Ahmad Makky, Romina Eslami Sarokhalil, Nazzareno D'Avanzo
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Cannabinoids are a broad class of molecules that act primarily on neurons, affecting pain sensation, appetite, mood, learning, and memory. In addition to interacting with specific cannabinoid receptors (CBRs), cannabinoids can directly modulate the f
Externí odkaz:
https://doaj.org/article/d41f0e4769394d849e66a474b34ddb02
Publikováno v:
Biology Open, Vol 11, Iss 3 (2022)
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are widely expressed in neurons in the central nervous system. It has been documented that HCN channels regulate the intrinsic excitability of pyramidal cells in the medial prefrontal
Externí odkaz:
https://doaj.org/article/f5aa04ecd2ff4d8689718a326f452fd5