Zobrazeno 1 - 10
of 139
pro vyhledávání: '"HCAR1"'
Autor:
Kathrine Lundø, Oksana Dmytriyeva, Louise Spøhr, Eliana Goncalves-Alves, Jiayi Yao, Laia P. Blasco, Mette Trauelsen, Muthulakshmi Ponniah, Marc Severin, Albin Sandelin, Marie Kveiborg, Thue W. Schwartz, Stine F. Pedersen
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-20 (2023)
Abstract Background The lactate receptor GPR81 contributes to cancer development through unclear mechanisms. Here, we investigate the roles of GPR81 in three-dimensional (3D) and in vivo growth of breast cancer cells and study the molecular mechanism
Externí odkaz:
https://doaj.org/article/4dce1bc40e524fe2bbe93834d25ecd0f
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-7 (2023)
Abstract The GPCR HCAR1 is known to be the sole receptor for lactate, which modulates its metabolic effects. Despite its significant role in many processes, mice deficient in HCAR1 exhibit no visible phenotype and are healthy and fertile. We performe
Externí odkaz:
https://doaj.org/article/851871c6b90e45f5bef76bcec45d9e36
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106207- (2023)
Over the last decades, lactate has emerged as important energy substrate for the brain fueling of neurons. A growing body of evidence now indicates that it is also a signaling molecule modulating neuronal excitability and activity as well as brain fu
Externí odkaz:
https://doaj.org/article/281f11391e99477b9389e6484c0de79c
Autor:
Samuel J. Geiseler, Alena Hadzic, Marvin Lambertus, Karl Martin Forbord, Ghazal Sajedi, Arthur Liesz, Cecilie Morland
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1232 (2024)
Stroke is the main cause for acquired disabilities. Pharmaceutical or mechanical removal of the thrombus is the cornerstone of stroke treatment but can only be administered to a subset of patients and within a narrow time window. Novel treatment opti
Externí odkaz:
https://doaj.org/article/41699001ceec44d4a5ea9325561409f4
Autor:
Shicun Zhang, Fang Wu, Lan Zhan, Wennan Lin, Chunming Liang, Yu Pang, Jiawen Zhang, Zhuang Mu
Publikováno v:
Iranian Journal of Public Health, Vol 51, Iss 10 (2022)
Background: We aimed to explore the ole and mechanism of lactate receptor (HCAR1) in the angiogenesis of leptomeningeal fibroblast-like cells. Methods: Human brain fibroblast-like cells were selected and some cells were deactivated, analyzed and c
Externí odkaz:
https://doaj.org/article/f3dde62a502b4b8ea6cfd4a4f65db667
Akademický článek
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Autor:
Lauritz Kennedy, Emilie R Glesaaen, Vuk Palibrk, Marco Pannone, Wei Wang, Ali Al-Jabri, Rajikala Suganthan, Niklas Meyer, Marie Landa Austbø, Xiaolin Lin, Linda H Bergersen, Magnar Bjørås, Johanne E Rinholm
Publikováno v:
eLife, Vol 11 (2022)
Neonatal cerebral hypoxia-ischemia (HI) is the leading cause of death and disability in newborns with the only current treatment being hypothermia. An increased understanding of the pathways that facilitate tissue repair after HI may aid the developm
Externí odkaz:
https://doaj.org/article/cbd0ebdeffa14ea4b5e69b80e8fa4039
Autor:
Lucia Longhitano, Nunzio Vicario, Daniele Tibullo, Cesarina Giallongo, Giuseppe Broggi, Rosario Caltabiano, Giuseppe Maria Vincenzo Barbagallo, Roberto Altieri, Marta Baghini, Michelino Di Rosa, Rosalba Parenti, Antonio Giordano, Maria Caterina Mione, Giovanni Li Volti
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The tumor microenvironment (TME) plays a pivotal role in establishing malignancy, and it is associated with high glycolytic metabolism and lactate release through monocarboxylate transporters (MCTs). Several lines of evidence suggest that lactate als
Externí odkaz:
https://doaj.org/article/fb35dcd54d6f419bb4ae1b4a42baf9f9
Autor:
Lucia Longhitano, Sebastiano Giallongo, Laura Orlando, Giuseppe Broggi, Antonio Longo, Andrea Russo, Rosario Caltabiano, Cesarina Giallongo, Ignazio Barbagallo, Michelino Di Rosa, Rosario Giuffrida, Rosalba Parenti, Giovanni Li Volti, Nunzio Vicario, Daniele Tibullo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 24 (2022)
Uveal melanoma (UM), the most common primary intraocular cancer in adults, is among the tumors with poorer prognosis. Recently, the role of the oncometabolite lactate has become attractive due to its role as hydroxycarboxylic acid receptor 1 (HCAR1)
Externí odkaz:
https://doaj.org/article/d1d82f0fc8824e6795d38a9d33bdf9ef